Abstract：
:Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for homeostatic control, this new framework puts inhibition in the driver's seat. Complex neuronal networks in the brain comprise many configurations in parallel, controlled by external and internal 'switches'. Context-dependent modulation and plasticity of inhibitory connections play a key role in memory and learning. It is therefore important to realize that synaptic plasticity is often multisynaptic and that a proper balance between excitation and inhibition is not fixed, but depends on context and activity level.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Herstel LJ,Wierenga CJdoi
10.1016/j.conb.2020.08.001subject
Has Abstractpub_date
2020-08-24 00:00:00pages
34-41eissn
0959-4388issn
1873-6882pii
S0959-4388(20)30112-4journal_volume
67pub_type
杂志文章,评审abstract：:The ionotropic GABA receptor (GABAAR) mediates fast inhibition in the brain. The GABAAR pore-forming (α, β, and non-α/β) subunits were isolated approximately 30 years ago and have since been the focus of extensive studies. As a result, many properties of GABAARs, including subunit assembly and channel and pharmacologi...
journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2005.03.016
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2008.04.003
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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