Axon and dendrite pruning in Drosophila.

abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

journal_title：Current opinion in neurobiology

authors： Brown HD,Kosslyn SM

更新日期：1993-04-01 00:00:00

abstract：:Despite considerable effort over a century and the benefit of remarkable technical advances in the past few decades, we are still far from understanding mammalian cerebral neocortex. With its six layers, modular architecture, canonical circuits, innumerable cell types, and computational complexity, isocortex remains a...

journal_title：Current opinion in neurobiology

authors： Fournier J,Müller CM,Laurent G

更新日期：2015-04-01 00:00:00

abstract：:Biological systems use internal circadian clocks to efficiently organize physiological and behavioral activity within the 24-hour time domain. In the absence of time cues, circadian periods vary slightly from 24 hours, but in nature, ambient light serves as the most salient synchronizer for these rhythms, fine-tuning ...

journal_title：Current opinion in neurobiology

authors： Davidson AJ,Menaker M

更新日期：2003-12-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...

journal_title：Current opinion in neurobiology

authors： Kording KP

更新日期：2014-04-01 00:00:00

abstract：:In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. ...

journal_title：Current opinion in neurobiology

authors： Platisa J,Pieribone VA

更新日期：2018-06-01 00:00:00

abstract：:Glioblastoma (GBM) are aggressive and therapy-resistant brain tumours driven by glioma stem-like cells (GSCs). GSC behaviour is controlled by the microenvironment, or niche, in which the cells reside. It is well-established that the vasculature is a key component of the GSC niche, which drives maintenance in the tumou...

journal_title：Current opinion in neurobiology

authors： Brooks LJ,Parrinello S

更新日期：2017-12-01 00:00:00

abstract：:How does auditory cortex represent auditory stimuli, and how do these representations contribute to behavior? Recent experimental evidence suggests that activity in auditory cortex consists of sparse and highly synchronized volleys of activity, observed both in anesthetized and awake animals. Many neurons are capable ...

journal_title：Current opinion in neurobiology

authors： Hromádka T,Zador AM

更新日期：2009-08-01 00:00:00

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:A novel multigene family has been identified that is likely to encode odorant receptors on olfactory sensory neurons. Further studies on this gene family are likely to shed light on the molecular mechanisms underlying information coding in the mammalian olfactory system. This review is also published in Current Opinio...

journal_title：Current opinion in neurobiology

authors： Buck LB

更新日期：1992-06-01 00:00:00

abstract：:The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...

journal_title：Current opinion in neurobiology

authors： Sossin WS,Lacaille JC

更新日期：2010-08-01 00:00:00

abstract：:Associative fear learning in the basolateral amygdala (BLA) is crucial for an animal's survival upon environmental threats. BLA neurons are defined on the basis of their projection target, genetic markers, and associated function. BLA principal neuron responses to threat signaling stimuli are potentiated upon associat...

journal_title：Current opinion in neurobiology

authors： Gründemann J,Lüthi A

更新日期：2015-12-01 00:00:00

abstract：:The prominent view that the rodent hippocampus is dedicated to spatial memory has been challenged recently by observations that both limit the nature of hippocampal spatial representation and extend its scope beyond literal space. These findings reveal that the rodent hippocampus mediates memory representations on the...

journal_title：Current opinion in neurobiology

authors： Eichenbaum H

更新日期：1996-04-01 00:00:00

abstract：:Animal eyes have long served as a classical example of independent origin followed by convergence of structures onto a few different solutions. During the past decade this view has been challenged by the discovery of shared developmental regulatory genes. The Pax6 gene in particular is almost universally employed for ...

journal_title：Current opinion in neurobiology

authors： Nilsson DE

更新日期：2004-08-01 00:00:00

abstract：:The rapid accumulation of neuroproteomics data in recent years has prompted the emergence of novel antibody-based imaging methods that aim to understand the anatomical and functional context of the multitude of identified proteins. The pioneering field of ultrastructural multiplexed proteomic imaging now includes a nu...

journal_title：Current opinion in neurobiology

authors： Micheva KD,Bruchez MP

更新日期：2012-02-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:The microcircuitry of the neocortex is bewildering in its anatomical detail, but seen through the filters of physiology, some simple circuits have been suggested. Intensive investigations of the cortical representation of orientation, however, show how difficult it is to achieve any consensus on what the circuits are,...

journal_title：Current opinion in neurobiology

authors： Martin KA

更新日期：2002-08-01 00:00:00

abstract：:High densities of acetylcholine receptors and sodium channels in the crests and troughs of the postsynaptic folds, respectively, ensure reliable neuromuscular signalling. Clustering of both ion channels is mediated by agrin. In the case of acetylcholine receptors, agrin activates the tyrosine kinase receptor muscle-sp...

journal_title：Current opinion in neurobiology

authors： Colledge M,Froehner SC

更新日期：1998-06-01 00:00:00

abstract：:Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca(2+)-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically ...

journal_title：Current opinion in neurobiology

authors： Hardie RC,Juusola M

更新日期：2015-10-01 00:00:00

abstract：:The pinnipeds provide a variety of clues to those interested in the vocal learning capabilities of non-human animals. Observational and experimental studies of seals, sea lions, and walruses reveal elements of vocal development, contextual control, plasticity in expression and learning, and even imitation of complex s...

journal_title：Current opinion in neurobiology

authors： Reichmuth C,Casey C

更新日期：2014-10-01 00:00:00

abstract：:Our ability to learn and control the motor aspects of complex laryngeal behaviors, such as speech and song, is modulated by the laryngeal motor cortex (LMC), which is situated in the area 4 of the primary motor cortex and establishes both direct and indirect connections with laryngeal motoneurons. In contrast, the LMC...

journal_title：Current opinion in neurobiology

authors： Simonyan K

更新日期：2014-10-01 00:00:00

abstract：:Helping involves other-oriented actions that have the potential to benefit another. The last ten years has seen the introduction of several experimental paradigms to study helping in rats. In the best characterized of these, a free rat opens a door to release a rat trapped in an acrylic tube or pool of water. Helping ...

journal_title：Current opinion in neurobiology

authors： Mason P

更新日期：2021-01-23 00:00:00

abstract：:Central pattern generators are subject to extensive modulation that generates flexibility in the rhythmic outputs of these neural networks. The effects of neuromodulators interact with one another, and modulatory neurons are themselves often subject to modulation, enabling both higher order control and indirect intera...

journal_title：Current opinion in neurobiology

authors： Dickinson PS

更新日期：2006-12-01 00:00:00

abstract：:Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys. Then, we show that it reflects many factors, maintenance of the items presented, preparation for the response, transformation of the items dur...

journal_title：Current opinion in neurobiology

authors： Passingham D,Sakai K

更新日期：2004-04-01 00:00:00

abstract：:The lateral line system is simple (comprising six cell types), its sense organs form according to a defined and reproducible pattern, and its neurons are easily visualized. In the zebrafish, these advantages can be combined with a wealth of genetic tools, making this system ideally suited to a combined molecular, cell...

journal_title：Current opinion in neurobiology

authors： Ghysen A,Dambly-Chaudière C

更新日期：2004-02-01 00:00:00

abstract：:The crustacean stomatogastric nervous system is a long-standing test bed for studies of circuit dynamics and neuromodulation. We give a brief update on the most recent work on this system, with an emphasis on the broader implications for understanding neural circuits. In particular, we focus on new findings underlinin...

journal_title：Current opinion in neurobiology

authors： Daur N,Nadim F,Bucher D

更新日期：2016-12-01 00:00:00

abstract：:Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...

journal_title：Current opinion in neurobiology

authors： McGehee DS,Role LW

更新日期：1996-06-01 00:00:00

abstract：:Perception, action, cognition, and emotion can now be mapped in the brain by a growing family of techniques. Positron emission tomography, functional magnetic resonance imaging, event-related electrical potentials, event-related magnetic fields, and other non-invasive imaging techniques are rapidly evolving and provid...

journal_title：Current opinion in neurobiology

authors： Fox PT,Woldorff MG

更新日期：1994-04-01 00:00:00

abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...

journal_title：Current opinion in neurobiology

authors： Lee MK,Borchelt DR,Wong PC,Sisodia SS,Price DL

更新日期：1996-10-01 00:00:00

abstract：:Tympanic hearing is a true evolutionary novelty that arose in parallel within early tetrapods. We propose that in these tetrapods, selection for sound localization in air acted upon pre-existing directionally sensitive brainstem circuits, similar to those in fishes. Auditory circuits in birds and lizards resemble this...

journal_title：Current opinion in neurobiology

authors： Carr CE,Christensen-Dalsgaard J

更新日期：2016-10-01 00:00:00