Looking for the roots of cortical sensory computation in three-layered cortices.

abstract：:The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the re...

journal_title：Current opinion in neurobiology

authors： Breer H,Boekhoff I

更新日期：1992-08-01 00:00:00

abstract：:A diverse group of biochemically distinct proteins give rise to amyloids, each of which is associated with a different disease. These amyloid proteins share numerous properties and typically arise from the abnormal processing of an amyloid precursor protein. The classification, mechanisms and biochemistry of amyloid f...

journal_title：Current opinion in neurobiology

authors： Castaño EM,Wisniewski T,Frangione B

更新日期：1991-10-01 00:00:00

abstract：:Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys. Then, we show that it reflects many factors, maintenance of the items presented, preparation for the response, transformation of the items dur...

journal_title：Current opinion in neurobiology

authors： Passingham D,Sakai K

更新日期：2004-04-01 00:00:00

abstract：:Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration. With 19 Wnts and 14 known receptors (10 Frizzl...

journal_title：Current opinion in neurobiology

authors： Onishi K,Hollis E,Zou Y

更新日期：2014-08-01 00:00:00

abstract：:Recent studies have provided a significant advance in our understanding of motor axon pathfinding. In particular, sources of guidance cues and some of the mechanisms used by motor growth cones during pathfinding have been identified. ...

journal_title：Current opinion in neurobiology

authors： Westerfield M

更新日期：1992-02-01 00:00:00

abstract：:Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differe...

journal_title：Current opinion in neurobiology

authors： Temple S,Qian X

更新日期：1996-02-01 00:00:00

abstract：:Modulation of local protein synthesis in neuronal dendrites plays a key role in the production of long-term, activity-dependent changes in synapse structure and functional efficacy. Such long-term changes also require regulation of actin dynamics in dendritic spines. Recent evidence couples local protein synthesis to ...

journal_title：Current opinion in neurobiology

authors： Bramham CR

更新日期：2008-10-01 00:00:00

abstract：:Learning is essential for animal survival under changing environments. Even in its simplest form, learning involves interactions between a handful of neuronal circuits, hundreds of neurons and many thousand synapses. In this review I will focus on habituation - a form of non-associative learning during which organisms...

journal_title：Current opinion in neurobiology

authors： López-Schier H

更新日期：2019-02-01 00:00:00

abstract：:How does auditory cortex represent auditory stimuli, and how do these representations contribute to behavior? Recent experimental evidence suggests that activity in auditory cortex consists of sparse and highly synchronized volleys of activity, observed both in anesthetized and awake animals. Many neurons are capable ...

journal_title：Current opinion in neurobiology

authors： Hromádka T,Zador AM

更新日期：2009-08-01 00:00:00

abstract：:Recent developments have led to a greater insight into the complex processes of perception of visual motion. A better understanding of the neuronal circuitry involved and advances in electrophysiological techniques have allowed researchers to alter the perception of an animal with a stimulating electrode. In addition,...

journal_title：Current opinion in neurobiology

authors： Snowden RJ

更新日期：1992-04-01 00:00:00

abstract：:Depression, conceptualized as major depressive disorder (MDD), is a complex psychiatric disorder with multiple behavioral changes and alterations in various brain regions. Biochemically, serotonin and others substances like GABA, glutamate, norepinephrin, adrenaline/noradrenaline play an essential role in the pathogen...

journal_title：Current opinion in neurobiology

authors： Northoff G

更新日期：2013-02-01 00:00:00

abstract：:Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and prote...

journal_title：Current opinion in neurobiology

authors： Nestler EJ

更新日期：1997-10-01 00:00:00

abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...

journal_title：Current opinion in neurobiology

authors： Rawson RL,Martin EA,Williams ME

更新日期：2017-08-01 00:00:00

abstract：:Ionotropic AMPA-type glutamate receptors and G-protein-coupled metabotropic GABAB receptors are key elements of neurotransmission whose cellular functions are determined by their protein constituents. Over the past couple of years unbiased proteomic approaches identified comprehensive sets of protein building blocks o...

journal_title：Current opinion in neurobiology

authors： Bettler B,Fakler B

更新日期：2017-08-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:The Drosophila visual system offers an excellent opportunity for studying the development of proper retinotopic connections at the level of individual identifiable cell types. Recent work suggests that, despite obvious anatomical and developmental differences, at least some of the general developmental strategies oper...

journal_title：Current opinion in neurobiology

authors： Kunes S,Steller H

更新日期：1993-02-01 00:00:00

abstract：:Cell-cell communication directs the development of photoreceptor cells in the Drosophila retina. A recent set of studies has provided a genetic dissection of one of these interactions, the induction of the R7 photoreceptor cell by the neighboring R8 photoreceptor cell. The results from these experiments shape our unde...

journal_title：Current opinion in neurobiology

authors： Krämer H,Cagan RL

更新日期：1994-02-01 00:00:00

abstract：:The microcircuitry of the neocortex is bewildering in its anatomical detail, but seen through the filters of physiology, some simple circuits have been suggested. Intensive investigations of the cortical representation of orientation, however, show how difficult it is to achieve any consensus on what the circuits are,...

journal_title：Current opinion in neurobiology

authors： Martin KA

更新日期：2002-08-01 00:00:00

abstract：:In many regions of the brain, information is represented by patterns of activity occurring over populations of neurons. Understanding the encoding of information in neural population activity is important both for grasping the fundamental computations underlying brain function, and for interpreting signals that may be...

journal_title：Current opinion in neurobiology

authors： Sanger TD

更新日期：2003-04-01 00:00:00

abstract：:Our understanding of the central nervous system (CNS) development has been strongly enhanced by the recent progress of single-cell multiomics approaches. Certainly, the multiplex profiling of individual cell epigenomes and transcriptomes together with dynamic lineage tracing systems brings encouraging new perspectives...

journal_title：Current opinion in neurobiology

authors： Solanelles-Farré L,Telley L

更新日期：2020-11-07 00:00:00

abstract：:The development of increasingly sophisticated methods for recording and manipulating neural activity is revolutionizing neuroscience. By probing how activity patterns in different types of neurons and circuits contribute to behavior, these tools can help inform mechanistic models of brain function and explain the role...

journal_title：Current opinion in neurobiology

authors： Wolff SB,Ölveczky BP

更新日期：2018-04-01 00:00:00

abstract：:Not only is the sense of smell of pivotal importance to most animals but also serves as a significant model system in biological research. In recent years, great strides in our understanding of how the olfactory system is organized and operates have been made. Instrumental in these efforts has been work performed in D...

journal_title：Current opinion in neurobiology

authors： Mansourian S,Stensmyr MC

更新日期：2015-10-01 00:00:00

abstract：:Visual system development utilizes global and local cues to assemble a topographic map of the visual world, arranging synaptic connections into columns and layers. Recent genetic studies have provided new insights into the mechanisms that underlie these processes. In flies, a precise temporal sequence of neural differ...

journal_title：Current opinion in neurobiology

authors： Clandinin TR,Feldheim DA

更新日期：2009-04-01 00:00:00

abstract：:Neuroscience research has become increasingly reliant upon quantitative and computational data analysis and modeling techniques. However, the vast majority of neuroscientists are still trained within the traditional biology curriculum, in which computational and quantitative approaches beyond elementary statistics may...

journal_title：Current opinion in neurobiology

authors： Goldman MS,Fee MS

更新日期：2017-10-01 00:00:00

abstract：:Mosquitoes use their sense of smell to find hosts, nectar, and oviposition sites, and to avoid repellents. A small number of mosquito species are adapted to feed on humans and have a major impact on public health by transmitting diseases such as malaria, dengue and filariasis. The application of odorants for behaviora...

journal_title：Current opinion in neurobiology

authors： Ray A

更新日期：2015-10-01 00:00:00

abstract：:Extracting the structure of complex environments is at the core of our ability to interpret the present and predict the future. This skill is important for a range of behaviours from navigating a new city to learning music and language. Classical approaches that investigate our ability to extract the principles of org...

journal_title：Current opinion in neurobiology

authors： Kourtzi Z,Welchman AE

更新日期：2019-10-01 00:00:00

abstract：:Huntington's disease (HD), a dominantly inherited neurodegenerative disease, is defined by its genetic cause, a CAG-repeat expansion in the HTT gene, its motor and psychiatric symptomology and primary loss of striatal medium spiny neurons (MSNs). However, the molecular mechanisms from genetic lesion to disease phenoty...

journal_title：Current opinion in neurobiology

authors： Veldman MB,Yang XW

更新日期：2018-02-01 00:00:00

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes th...

journal_title：Current opinion in neurobiology

authors： Carson JH,Kwon S,Barbarese E

更新日期：1998-10-01 00:00:00

abstract：:Classical conditioning, the simplest form of associative learning, is one of the most studied paradigms in behavioural psychology. Since the formal description of classical conditioning by Pavlov, lesion studies in animals have identified a number of anatomical structures involved in, and necessary for, classical cond...

journal_title：Current opinion in neurobiology

authors： Büchel C,Dolan RJ

更新日期：2000-04-01 00:00:00