Abstract:
:Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration. With 19 Wnts and 14 known receptors (10 Frizzleds (Fzds), Ryk, Ror1/2 and PTK7), the Wnt family signaling proteins contribute significantly to the wiring specificity of the complex brain and spinal cord circuitry. Subsequent investigation into the signaling mechanisms showed that conserved cell polarity pathways mediate growth cone steering. These cell polarity pathways may unveil general principles of growth cone guidance. The reappeared Wnt signaling system after spinal cord injury limits the regrowth of both descending and ascending motor and sensory axons. Therefore, the knowledge of Wnt signaling mechanisms learned from axon development can be applied to axon repair in adulthood.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Onishi K,Hollis E,Zou Ydoi
10.1016/j.conb.2014.05.005subject
Has Abstractpub_date
2014-08-01 00:00:00pages
232-40eissn
0959-4388issn
1873-6882pii
S0959-4388(14)00106-8journal_volume
27pub_type
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