Interoception: the sense of the physiological condition of the body.

abstract：:Fear and anxiety are debilitating conditions that affect a significant number of individuals in their lifetimes. Understanding underlying mechanisms of these disorders affords us the possibility of therapeutic intervention. Such clarity in terms of mechanism and intervention can only come from an amalgamation of resea...

journal_title：Current opinion in neurobiology

authors： Dias BG,Banerjee SB,Goodman JV,Ressler KJ

更新日期：2013-06-01 00:00:00

abstract：:The importance of the medial temporal lobe to episodic memory has been recognized for decades. Recent human fMRI findings have begun to delineate the functional roles of different MTL regions, most notably the hippocampus, for the retrieval of episodic memories. Importantly, these studies have also identified a networ...

journal_title：Current opinion in neurobiology

authors： Rugg MD,Vilberg KL

更新日期：2013-04-01 00:00:00

abstract：:The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabin...

journal_title：Current opinion in neurobiology

authors： Maldonado R,Robledo P,Berrendero F

更新日期：2013-08-01 00:00:00

abstract：:Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in...

journal_title：Current opinion in neurobiology

authors： Smith KR,Kittler JT

更新日期：2010-10-01 00:00:00

abstract：:Visual system development utilizes global and local cues to assemble a topographic map of the visual world, arranging synaptic connections into columns and layers. Recent genetic studies have provided new insights into the mechanisms that underlie these processes. In flies, a precise temporal sequence of neural differ...

journal_title：Current opinion in neurobiology

authors： Clandinin TR,Feldheim DA

更新日期：2009-04-01 00:00:00

abstract：:Associative fear learning in the basolateral amygdala (BLA) is crucial for an animal's survival upon environmental threats. BLA neurons are defined on the basis of their projection target, genetic markers, and associated function. BLA principal neuron responses to threat signaling stimuli are potentiated upon associat...

journal_title：Current opinion in neurobiology

authors： Gründemann J,Lüthi A

更新日期：2015-12-01 00:00:00

abstract：:A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance a...

journal_title：Current opinion in neurobiology

authors： Gatto G,Smith KM,Ross SE,Goulding M

更新日期：2019-06-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:The adult mammalian neocortex, the major region of the cerebral cortex, is divided into functionally specialized areas, defined by distinct architecture and axonal connections. Extrinsic influences, such as thalamocortical input, and genetic regulation, intrinsic to the dorsal telencephalon, control the gradual emerge...

journal_title：Current opinion in neurobiology

authors： O'Leary DD,Nakagawa Y

更新日期：2002-02-01 00:00:00

abstract：:The analysis of stimulus/response patterns using information theoretic approaches requires the full probability distribution of stimuli and response. Recent progress in using information-based tools to understand circuit function has advanced understanding of neural coding at the single cell and population level. In a...

journal_title：Current opinion in neurobiology

authors： Fairhall A,Shea-Brown E,Barreiro A

更新日期：2012-08-01 00:00:00

abstract：:Recent technological advances have enabled the use of different optical methods to activate neurons, including 'caged' glutamate, photoactivation of genetically engineered cascades, and direct two-photon excitation. The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the te...

journal_title：Current opinion in neurobiology

authors： Callaway EM,Yuste R

更新日期：2002-10-01 00:00:00

abstract：:The rapid accumulation of neuroproteomics data in recent years has prompted the emergence of novel antibody-based imaging methods that aim to understand the anatomical and functional context of the multitude of identified proteins. The pioneering field of ultrastructural multiplexed proteomic imaging now includes a nu...

journal_title：Current opinion in neurobiology

authors： Micheva KD,Bruchez MP

更新日期：2012-02-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:Sexual communication can evolve in response to sexual selection, and it can also cause behavioral reproductive isolation between populations and thus drive speciation. Anurans are an excellent system to investigate these links between behavior and evolution because we have detailed knowledge of how neural mechanisms g...

journal_title：Current opinion in neurobiology

authors： Ryan MJ,Guerra MA

更新日期：2014-10-01 00:00:00

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:The ionotropic GABA receptor (GABAAR) mediates fast inhibition in the brain. The GABAAR pore-forming (α, β, and non-α/β) subunits were isolated approximately 30 years ago and have since been the focus of extensive studies. As a result, many properties of GABAARs, including subunit assembly and channel and pharmacologi...

journal_title：Current opinion in neurobiology

authors： Tomita S

更新日期：2019-08-01 00:00:00

abstract：:Biological systems use internal circadian clocks to efficiently organize physiological and behavioral activity within the 24-hour time domain. In the absence of time cues, circadian periods vary slightly from 24 hours, but in nature, ambient light serves as the most salient synchronizer for these rhythms, fine-tuning ...

journal_title：Current opinion in neurobiology

authors： Davidson AJ,Menaker M

更新日期：2003-12-01 00:00:00

abstract：:In order to understand how brain activity produces adaptive behavior we need large-scale, high-resolution recordings of neuronal activity. Fluorescent genetically encoded voltage indicators (GEVIs) offer the potential for these recordings to be performed chronically from targeted cells in a minimally invasive manner. ...

journal_title：Current opinion in neurobiology

authors： Platisa J,Pieribone VA

更新日期：2018-06-01 00:00:00

abstract：:Sensory gating mechanisms are deployed during vertebrate locomotion to ensure that adaptive and appropriate motor responses to afferent input occur during all phases of the movement cycle. Recent animal studies on the integration of cutaneous information have investigated the roles of interneurones in sensory gating. ...

journal_title：Current opinion in neurobiology

authors： Sillar KT

更新日期：1991-12-01 00:00:00

abstract：:Enduring social bonds play an essential role in human society. These bonds positively affect psychological, physiological, and behavioral functions. Here, we review the recent literature on the neurobiology, particularly the role of oxytocin and dopamine, of pair bond formation, bond disruption, and social buffering e...

journal_title：Current opinion in neurobiology

authors： Lieberwirth C,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:This past year has seen significant advances in our understanding of the physiology of emotion. Attention continues to focus on the amygdala and its interconnections with prefrontal cortical regions. New evidence underscores the importance of lateralization for emotion. There are also new findings on the physiological...

journal_title：Current opinion in neurobiology

authors： Davidson RJ,Sutton SK

更新日期：1995-04-01 00:00:00

abstract：:The behavioral repertoire of an organism can be highly diverse, spanning from social to defensive. How an animal efficiently switches between distinct behaviors is a fundamental question whose inquiry will provide insights into the mechanisms that are necessary for an organism's survival. Previous work aimed at identi...

journal_title：Current opinion in neurobiology

authors： Rozeske RR,Herry C

更新日期：2018-10-01 00:00:00

abstract：:One of the seminal discoveries in developmental neuroscience is that altering visual experience through monocular deprivation can alter both the physiological and the anatomical representation of the two eyes, called ocular dominance columns, in primary visual cortex. This rearrangement is restricted to a critical per...

journal_title：Current opinion in neurobiology

authors： Feller MB,Scanziani M

更新日期：2005-02-01 00:00:00

abstract：:Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided st...

journal_title：Current opinion in neurobiology

authors： Linden DJ,Connor JA

更新日期：1993-06-01 00:00:00

abstract：:During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there ...

journal_title：Current opinion in neurobiology

authors： Reiner O,Parichha A,Sapir T

更新日期：2020-10-15 00:00:00

abstract：:All animals have a fundamental and unavoidable requirement for rest, yet we still do not fully understand the processes that initiate, maintain, and regulate sleep. The larval zebrafish is an optically translucent, genetically tractable model organism that exhibits sleep states regulated by conserved sleep circuits, t...

journal_title：Current opinion in neurobiology

authors： Barlow IL,Rihel J

更新日期：2017-06-01 00:00:00

abstract：:Comparative studies over the past year have revealed two new insights into the role of neuropeptides in the evolution of social behaviors. First, across vertebrate taxa, certain neuropeptide effects appear to be gender-specific. Second, species variations in receptor gene structure can alter neuropeptide receptor dist...

journal_title：Current opinion in neurobiology

authors： Insel TR,Young LJ

更新日期：2000-12-01 00:00:00

abstract：:This review connects several lines of research to argue that hyperbolic geometry should be broadly applicable to neural circuits as well as other biological circuits. The reason for this is that networks that conform to hyperbolic geometry are maximally responsive to external and internal perturbations. These networks...

journal_title：Current opinion in neurobiology

authors： Sharpee TO

更新日期：2019-10-01 00:00:00

abstract：:The suprachiasmatic nucleus of the hypothalamus and at least two other unidentified central pacemakers regulate the temporal structure of a circadian network that involves almost every organ in the body. Phase control is central to the efficient function of this system. Individual circadian oscillators in tissues and ...

journal_title：Current opinion in neurobiology

authors： Menaker M,Murphy ZC,Sellix MT

更新日期：2013-10-01 00:00:00

abstract：:For many years, it has been postulated that interactions between motor commands and somatic perception in the sensorimotor cortices exist, but they have been difficult to demonstrate. Recent studies have made demonstration of this interaction easier and suggest that cortical activity related to somatic sensation and p...

journal_title：Current opinion in neurobiology

authors： Nelson RJ

更新日期：1996-12-01 00:00:00