Abstract:
:Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in the dynamic regulation of inhibitory synaptic efficacy and plasticity. The regulatory pathways essential for the fine-tuning of synaptic inhibition have also emerged as key sites of vulnerability during pathological changes in cell excitability in disease states.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Smith KR,Kittler JTdoi
10.1016/j.conb.2010.06.001subject
Has Abstractpub_date
2010-10-01 00:00:00pages
550-6issue
5eissn
0959-4388issn
1873-6882pii
S0959-4388(10)00098-Xjournal_volume
20pub_type
杂志文章,评审abstract::The unfolded protein response (UPR) comprises kinase signaling and transcription factor activation cascades delineated over the past 20 years. Most studies conclude that this stress response is adaptive but, nevertheless, includes maladaptive programs involving CHOP expression that drives cell-autonomous apoptosis. He...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2009.08.007
更新日期:2009-10-01 00:00:00
abstract::In the past year, our knowledge of neurotransmitter transporters has increased significantly. Recently, new members of two families of plasma membrane uptake carriers have been cloned, and the stoichiometries, physiological function and mechanisms of modulation of some of these transporters are now better understood. ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(94)90096-5
更新日期:1994-06-01 00:00:00
abstract::Neuroepithelial cells, the progenitors to the CNS neurons and glia, undergo both symmetric and asymmetric divisions. Symmetric divisions underlie the proliferation of neuroepithelial cells that predominates early in CNS development. Asymmetric divisions are thought to generate the cell types derived from neuroepitheli...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(97)80117-1
更新日期:1997-02-01 00:00:00
abstract::Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.10.013
更新日期:2004-12-01 00:00:00
abstract::For many years, it has been postulated that interactions between motor commands and somatic perception in the sensorimotor cortices exist, but they have been difficult to demonstrate. Recent studies have made demonstration of this interaction easier and suggest that cortical activity related to somatic sensation and p...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80031-6
更新日期:1996-12-01 00:00:00
abstract::Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80118-8
更新日期:1996-06-01 00:00:00
abstract::The prominent view that the rodent hippocampus is dedicated to spatial memory has been challenged recently by observations that both limit the nature of hippocampal spatial representation and extend its scope beyond literal space. These findings reveal that the rodent hippocampus mediates memory representations on the...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80072-9
更新日期:1996-04-01 00:00:00
abstract::Neuropeptide Y is an important regulator of energy intake and expenditure. The central portion of this regulatory system appears to reside in the arcuate nucleus/paraventricular nucleus of the hypothalamus. The effects of neuropeptide Y on energy metabolism include increased food intake, decreased thermogenesis and in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(92)90144-a
更新日期:1992-12-01 00:00:00
abstract::Birds commonly use sound for communication between the sexes. In many songbird species, only males sing and there are pronounced sex differences in the neural song control circuits. By contrast, the auditory circuitry is largely similar in males and females. Both sexes learn to recognize vocalizations heard as juvenil...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.01.005
更新日期:2016-06-01 00:00:00
abstract::The investigation of mechanosensory feedback to locomotion has been hindered by the challenge of recording neurons in motion. Genetic accessibility and optical transparency of zebrafish larvae provide means to revisit this question. Glutamatergic Rohon-Beard (RB) and GABAergic CSF-contacting neurons (CSF-cNs) are spin...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.04.010
更新日期:2018-10-01 00:00:00
abstract::Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.08.013
更新日期:2011-02-01 00:00:00
abstract::Cell-cell communication directs the development of photoreceptor cells in the Drosophila retina. A recent set of studies has provided a genetic dissection of one of these interactions, the induction of the R7 photoreceptor cell by the neighboring R8 photoreceptor cell. The results from these experiments shape our unde...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(94)90026-4
更新日期:1994-02-01 00:00:00
abstract::For many years pathophysiological studies on patients with movement disorders were viewed as inferior to those in animal models because, given the complexity of dealing with the complete interconnected CNS, it was difficult to assign any particular physiological abnormality exclusively to the site of a known lesion. M...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2003.10.006
更新日期:2003-12-01 00:00:00
abstract::Reward valuation in social contexts is by nature relative rather than absolute; it is made in reference to others. This socially relative reward valuation is based on our propensity to conduct comparisons and competitions between self and other. Exploring its neural substrate has been an active area of research in hum...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2020.11.008
更新日期:2020-12-08 00:00:00
abstract::The visual system is tasked with extracting stimulus content (e.g. the identity of an object) from the spatiotemporal light pattern falling on the retina. However, visual information can be ambiguous with regard to content (e.g. an object when viewed from far away), requiring the system to also consider contextual inf...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.04.013
更新日期:2010-06-01 00:00:00
abstract::Sleep has been universally conserved across animal species. The basic functions of sleep remain unclear, but insufficient sleep impairs memory acquisition and retention in both vertebrates and invertebrates. Sleep is also a homeostatic process that is influenced not only by the amount of time awake, but also by neural...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.10.006
更新日期:2019-02-01 00:00:00
abstract::Recent behavioral studies of infants have provided further evidence for the existence of cognitive and perceptual abilities in the first few months of life. Additional evidence from developmental neuroscience and comparative psychology has supported the view that, in some domains, such as visual attention and face and...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(94)90076-0
更新日期:1994-04-01 00:00:00
abstract::The study of spatial maps of the ventral sensory-motor cortex (vSMC) dates back to the earliest cortical stimulation studies. This review surveys a number of recent and historical reports of the features and function of spatial maps within vSMC towards the human behavior of speaking. Representations of the vocal tract...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.08.015
更新日期:2014-02-01 00:00:00
abstract::The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology. Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses hav...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80088-2
更新日期:1996-10-01 00:00:00
abstract::Auditory cortical maps have been a long-standing focus of studies that assess the expression, mechanisms, and consequences of sensory plasticity. Here we discuss recent progress in understanding how auditory experience transforms spatially organized sound representations at higher levels of the central auditory pathwa...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.11.009
更新日期:2014-02-01 00:00:00
abstract::Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys. Then, we show that it reflects many factors, maintenance of the items presented, preparation for the response, transformation of the items dur...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.03.003
更新日期:2004-04-01 00:00:00
abstract::Recent studies have provided a significant advance in our understanding of motor axon pathfinding. In particular, sources of guidance cues and some of the mechanisms used by motor growth cones during pathfinding have been identified. ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(92)90157-g
更新日期:1992-02-01 00:00:00
abstract::Biology provides examples of efficient machines which greatly outperform conventional technology. Designers in neuromorphic engineering aim to construct electronic systems with the same efficient style of computation. This task requires a melding of novel engineering principles with knowledge gleaned from neuroscience...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.03.007
更新日期:2010-06-01 00:00:00
abstract::Modulation of local protein synthesis in neuronal dendrites plays a key role in the production of long-term, activity-dependent changes in synapse structure and functional efficacy. Such long-term changes also require regulation of actin dynamics in dendritic spines. Recent evidence couples local protein synthesis to ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.09.013
更新日期:2008-10-01 00:00:00
abstract::Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(98)80071-8
更新日期:1998-06-01 00:00:00
abstract::Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cy...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80112-7
更新日期:1996-06-01 00:00:00
abstract::Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(95)80063-8
更新日期:1995-10-01 00:00:00
abstract::The recent invention of super-resolution fluorescence microscopy brings more than an order of magnitude gain in the spatial resolution of light microscopy. New opportunities keep emerging with the multicolor, three-dimensional, and live imaging functionalities gained in the past three years. The power of this technolo...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.07.006
更新日期:2010-10-01 00:00:00
abstract::We discuss very recent experiments with rodents addressing the idea that long-term memories initially depending on the hippocampus, over a prolonged period, become independent of it. No unambiguous recent evidence exists to substantiate that this occurs. Most experiments find that recent and remote memories are equall...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章
doi:10.1016/j.conb.2011.04.007
更新日期:2011-06-01 00:00:00
abstract::Slow waves, the hallmark of NREM (Non Rapid Eye Movement) sleep, are not uniformly distributed across the cortical surface, but can occur locally and asynchronously across brain regions. Their regional distribution and amplitude is affected by brain maturation and by time spent awake, mediated in part by experience-de...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.05.008
更新日期:2017-06-01 00:00:00