Genetically encoded fluorescent voltage indicators: are we there yet?

abstract：:Recent behavioral studies of infants have provided further evidence for the existence of cognitive and perceptual abilities in the first few months of life. Additional evidence from developmental neuroscience and comparative psychology has supported the view that, in some domains, such as visual attention and face and...

journal_title：Current opinion in neurobiology

authors： Johnson MH

更新日期：1994-04-01 00:00:00

abstract：:Major technical advances in the imaging of live cells have led to a recent flurry of studies demonstrating how dendrites remodel dynamically during development. Taken together with our current understanding of axonal development, these studies help provide a more unified picture of how neural circuits might be formed ...

journal_title：Current opinion in neurobiology

authors： Wong WT,Wong RO

更新日期：2000-02-01 00:00:00

abstract：:Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic st...

journal_title：Current opinion in neurobiology

authors： Blanquie O,Bradke F

更新日期：2018-08-01 00:00:00

abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

journal_title：Current opinion in neurobiology

authors： Brown HD,Kosslyn SM

更新日期：1993-04-01 00:00:00

abstract：:The importance of the medial temporal lobe to episodic memory has been recognized for decades. Recent human fMRI findings have begun to delineate the functional roles of different MTL regions, most notably the hippocampus, for the retrieval of episodic memories. Importantly, these studies have also identified a networ...

journal_title：Current opinion in neurobiology

authors： Rugg MD,Vilberg KL

更新日期：2013-04-01 00:00:00

abstract：:Work during the past year has revealed increasing diversity and complexity of sensory inputs that trigger behavior, and correspondingly wide-ranging adaptations of sensory receptors and receptor organs. Many of these have been discovered by taking careful account of the animal in its natural habitat. Studies on centra...

journal_title：Current opinion in neurobiology

authors： Camhi JM

更新日期：1993-12-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:Peripheral nerves show a remarkable ability to regenerate following a transection injury. Downstream of the cut, the axons degenerate and so to regenerate the nerve, the severed axons need to regrow back to their targets and regain function. This requires the axons to navigate through two different environments. (1) T...

journal_title：Current opinion in neurobiology

authors： Cattin AL,Lloyd AC

更新日期：2016-08-01 00:00:00

abstract：:Learning is essential for animal survival under changing environments. Even in its simplest form, learning involves interactions between a handful of neuronal circuits, hundreds of neurons and many thousand synapses. In this review I will focus on habituation - a form of non-associative learning during which organisms...

journal_title：Current opinion in neurobiology

authors： López-Schier H

更新日期：2019-02-01 00:00:00

abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

journal_title：Current opinion in neurobiology

authors： Griffith LC

更新日期：2012-08-01 00:00:00

abstract：:The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...

journal_title：Current opinion in neurobiology

authors： Sossin WS,Lacaille JC

更新日期：2010-08-01 00:00:00

abstract：:Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring. In this review, w...

journal_title：Current opinion in neurobiology

authors： Nugent AA,Kolpak AL,Engle EC

更新日期：2012-10-01 00:00:00

abstract：:Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...

journal_title：Current opinion in neurobiology

authors： McGehee DS,Role LW

更新日期：1996-06-01 00:00:00

abstract：:Songbirds are a productive model organism to study the neural basis of auditory-guided vocal motor learning. Like human babies, juvenile songbirds learn many of their vocalizations by imitating an adult conspecific. This process is a product of genetic predispositions and the individual's life experience and has been ...

journal_title：Current opinion in neurobiology

authors： Scharff C,Adam I

更新日期：2013-02-01 00:00:00

abstract：:Enduring social bonds play an essential role in human society. These bonds positively affect psychological, physiological, and behavioral functions. Here, we review the recent literature on the neurobiology, particularly the role of oxytocin and dopamine, of pair bond formation, bond disruption, and social buffering e...

journal_title：Current opinion in neurobiology

authors： Lieberwirth C,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to par...

journal_title：Current opinion in neurobiology

authors： Kaller MS,Lazari A,Blanco-Duque C,Sampaio-Baptista C,Johansen-Berg H

更新日期：2017-12-01 00:00:00

abstract：:Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found i...

journal_title：Current opinion in neurobiology

authors： Augustine GJ

更新日期：2001-06-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of s...

journal_title：Current opinion in neurobiology

authors： Martin KC

更新日期：2004-06-01 00:00:00

abstract：:How is an ant-equipped with a brain that barely exceeds the size of a pinhead-capable of achieving navigational marvels? Even though evidences suggest that navigation is a multimodal process, ants heavily depend on olfactory cues-of pheromonal and non-pheromonal nature-for foraging and orientation. Recent studies have...

journal_title：Current opinion in neurobiology

authors： Steck K

更新日期：2012-04-01 00:00:00

abstract：:Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

journal_title：Current opinion in neurobiology

authors： Lüningschrör P,Sendtner M

更新日期：2018-08-01 00:00:00

abstract：:Genetically encoded sensors of neural activity enable visualization of circuit-level function in the central nervous system. Although our understanding of the molecular events that regulate neuronal firing, synaptic function, and plasticity has expanded rapidly over the past 15 years, an appreciation for how cellular ...

journal_title：Current opinion in neurobiology

authors： Barth AL

更新日期：2007-10-01 00:00:00

abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...

journal_title：Current opinion in neurobiology

authors： Rawson RL,Martin EA,Williams ME

更新日期：2017-08-01 00:00:00

abstract：:Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lea...

journal_title：Current opinion in neurobiology

authors： Wang C,Telpoukhovskaia MA,Bahr BA,Chen X,Gan L

更新日期：2018-02-01 00:00:00

abstract：:Endogenous nitric oxide (NO) mediates certain aspects of synaptic plasticity and neurotoxicity associated with NMDA-type glutamate receptors. Neuronal NO synthase contains a modular protein-protein interaction motif, termed the PDZ domain, that links the synthase to a synaptic protein complex containing postsynaptic d...

journal_title：Current opinion in neurobiology

authors： Brenman JE,Bredt DS

更新日期：1997-06-01 00:00:00

abstract：:High densities of acetylcholine receptors and sodium channels in the crests and troughs of the postsynaptic folds, respectively, ensure reliable neuromuscular signalling. Clustering of both ion channels is mediated by agrin. In the case of acetylcholine receptors, agrin activates the tyrosine kinase receptor muscle-sp...

journal_title：Current opinion in neurobiology

authors： Colledge M,Froehner SC

更新日期：1998-06-01 00:00:00

abstract：:Growth cones, the highly motile tips of growing axons, guide axons to their targets by responding to molecular cues. Growth cone behaviors such as advancing, retracting, turning and branching are driven by the dynamics and reorganization of the actin and microtubule cytoskeleton through signaling pathways linked to gu...

journal_title：Current opinion in neurobiology

authors： Kalil K,Dent EW

更新日期：2005-10-01 00:00:00

abstract：:Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...

journal_title：Current opinion in neurobiology

authors： Kording KP

更新日期：2014-04-01 00:00:00

abstract：:Cognitive neuroimaging maps the brain locations of mental operations. This process is iterative, as no single study can fully characterize a mental operation or its brain location. This iterative discovery process, in combination with the location-reporting standard (i.e. spatial coordinates) of the cognitive neuroima...

journal_title：Current opinion in neurobiology

authors： Fox PT,Parsons LM,Lancaster JL

更新日期：1998-04-01 00:00:00