Abstract:
:Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to participate in nervous system plasticity beyond development. While the link between experience and myelination gains increased recognition, it is still unclear what role such adaptive myelination plays in facilitating and shaping behaviour. Additionally, fundamental mechanisms and principles underlying myelin remodelling remain poorly understood. In this review, we will discuss new insights into the link between myelin plasticity and behaviour, as well as mechanistic aspects of myelin remodelling that may help to elucidate this intriguing process.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Kaller MS,Lazari A,Blanco-Duque C,Sampaio-Baptista C,Johansen-Berg Hdoi
10.1016/j.conb.2017.09.014subject
Has Abstractpub_date
2017-12-01 00:00:00pages
86-92eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30098-3journal_volume
47pub_type
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