Abstract:
:The issue of whether encoding of geometric information for navigational purposes crucially depends on environmental experience or whether it is innately predisposed in the brain has been recently addressed in controlled rearing studies. Non-human animals can make use of the geometric shape of an environment for spatial reorientation and in some circumstances reliance on purely geometric information (metric properties and sense) can overcome use of local featural information. Animals reared in home cages of different geometric shapes proved to be equally capable of learning and performing navigational tasks based on geometric information. The findings suggest that effective use of geometric information for spatial reorientation does not require experience in environments with right angles and metrically distinct surfaces.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Vallortigara G,Sovrano VA,Chiandetti Cdoi
10.1016/j.conb.2009.02.002subject
Has Abstractpub_date
2009-02-01 00:00:00pages
20-6issue
1eissn
0959-4388issn
1873-6882pii
S0959-4388(09)00004-Xjournal_volume
19pub_type
杂志文章,评审abstract::Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of th...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80082-1
更新日期:1996-04-01 00:00:00
abstract::Neuroepithelial cells, the progenitors to the CNS neurons and glia, undergo both symmetric and asymmetric divisions. Symmetric divisions underlie the proliferation of neuroepithelial cells that predominates early in CNS development. Asymmetric divisions are thought to generate the cell types derived from neuroepitheli...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(97)80117-1
更新日期:1997-02-01 00:00:00
abstract::Opiate drugs such as morphine and heroin are among the most effective analgesics known. Prolonged or repeated administration of opiates produces adaptive changes in the nervous system that lead to reduced drug potency or efficacy (tolerance), as well as physiological withdrawal symptoms and behavioral manifestations s...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00069-2
更新日期:2003-06-01 00:00:00
abstract::Not only is the sense of smell of pivotal importance to most animals but also serves as a significant model system in biological research. In recent years, great strides in our understanding of how the olfactory system is organized and operates have been made. Instrumental in these efforts has been work performed in D...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.02.006
更新日期:2015-10-01 00:00:00
abstract::Cognitive development is determined by both genetics and environment. One point of convergence of these two influences is the neural activity-dependent regulation of programs of gene expression that specify neuronal fate and function. Human genetic studies have linked several transcriptional regulators to neurodevelop...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.01.002
更新日期:2005-02-01 00:00:00
abstract::Ca2+ entry into neurons is one of the major effectors of stimulus-induced physiological change. Ca2+ can enter neurons through a number of different voltage-gated and ligand-gated channels. Depending on the route of entry, Ca2+ stimulates distinct intracellular signaling pathways, which activate different sets of gene...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(95)80050-6
更新日期:1995-06-01 00:00:00
abstract::Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.06.007
更新日期:2004-08-01 00:00:00
abstract::The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.03.011
更新日期:2010-08-01 00:00:00
abstract::Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton. Ankyrin g...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2021.01.002
更新日期:2021-01-20 00:00:00
abstract::Fear and anxiety are debilitating conditions that affect a significant number of individuals in their lifetimes. Understanding underlying mechanisms of these disorders affords us the possibility of therapeutic intervention. Such clarity in terms of mechanism and intervention can only come from an amalgamation of resea...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.01.013
更新日期:2013-06-01 00:00:00
abstract::Nearly all studies of natural variation within clock genes involve the period (per) locus, which was originally isolated in the fruit-fly. Intra- and interspecific work on per has focused mostly on a region of Thr-Gly or Ser-Gly repeats, which show rapid length and sequence evolution. The functional implications of nu...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(98)80096-2
更新日期:1998-10-01 00:00:00
abstract::Slow wave activity (SWA) during slow wave sleep (SWS) is the best indicator of the sleep homeostasis. The intensity of the SWA observed during SWS that follows prolonged waking is directly correlated with the duration of prior waking and its intensity decays during SWS suggesting a buildup and a resolution of sleep ne...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.05.015
更新日期:2017-06-01 00:00:00
abstract::Recent developments have led to a greater insight into the complex processes of perception of visual motion. A better understanding of the neuronal circuitry involved and advances in electrophysiological techniques have allowed researchers to alter the perception of an animal with a stimulating electrode. In addition,...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(92)90008-9
更新日期:1992-04-01 00:00:00
abstract::Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.05.003
更新日期:2016-10-01 00:00:00
abstract::Prions cause transmissible and genetic neurodegenerative diseases. Infectious prion particles are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrPSc), which is encoded by a chromosomal gene. Although the PrP gene is single copy, transgenic mice with both alleles of the PrP gene ablat...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(92)90032-g
更新日期:1992-10-01 00:00:00
abstract::The crustacean stomatogastric nervous system is a long-standing test bed for studies of circuit dynamics and neuromodulation. We give a brief update on the most recent work on this system, with an emphasis on the broader implications for understanding neural circuits. In particular, we focus on new findings underlinin...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.07.005
更新日期:2016-12-01 00:00:00
abstract::Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.06.001
更新日期:2010-10-01 00:00:00
abstract::Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific 'labeled-lines' to multimodal...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.04.006
更新日期:2018-10-01 00:00:00
abstract::Converging evidence indicates that primates have a distinct cortical image of homeostatic afferent activity that reflects all aspects of the physiological condition of all tissues of the body. This interoceptive system, associated with autonomic motor control, is distinct from the exteroceptive system (cutaneous mecha...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00090-4
更新日期:2003-08-01 00:00:00
abstract::The cadherin superfamily is a large (now more than 100 proteins) protein family originally identified as cell adhesion molecules. Each cadherin shows distinct expression patterns in the nervous system, and their expressions are both spatially and temporally regulated and diverse among different species. Mounting evide...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.06.001
更新日期:2014-10-01 00:00:00
abstract::Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable neuroengineering capabilities. In this review, we provide an accessible primer ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.06.008
更新日期:2019-10-01 00:00:00
abstract::Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.08.010
更新日期:2004-10-01 00:00:00
abstract::The discovery of hair cell regeneration in the inner ear of birds provides new optimism that there may be a treatment for hearing and balance disorders. In this review we describe the process of hair cell regeneration in birds; including restoration of function, recovery of perception and what is currently known about...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00018-7
更新日期:2003-02-01 00:00:00
abstract::Unravelling the mechanisms of learning and memory can, and should, be tackled at many levels. Discovery of the huge family of odourant receptor genes provided olfaction with 'molecular' respectability similar to that afforded to the visual system. Consequently, molecular studies have dominated the olfactory literature...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(95)80009-3
更新日期:1995-08-01 00:00:00
abstract::The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.11.007
更新日期:2014-04-01 00:00:00
abstract::Processing of auditory information requires constant adjustment due to alterations of the environment and changing conditions in the nervous system with age, health, and experience. Consequently, patterns of activity in cortical networks have complex dynamics over a wide range of timescales, from milliseconds to days ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.10.003
更新日期:2015-12-01 00:00:00
abstract::Recent functional brain imaging studies of the neurobiology of emotion have investigated how individual differences among subjects modulate neural responses during emotion processing. Differences in personality, dispositional affect, biological sex, and genotype can all substantially modulate the neural bases of emoti...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.03.010
更新日期:2004-04-01 00:00:00
abstract::Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(97)80080-3
更新日期:1997-10-01 00:00:00
abstract::The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.04.010
更新日期:2011-12-01 00:00:00
abstract::The study of plasticity in the central nervous system is a major and very dynamic neuroscience research field with enormous clinical potential. Considerable advances in this field have been made during the past 10 years. It now appears that most circuits in the brain and spinal cord show plasticity and that they can b...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.10.009
更新日期:2004-12-01 00:00:00