CREB and the formation of long-term memory.

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:Classical eyelid conditioning has been used to great advantage in demonstrating that the cerebellum helps to improve movements through experience, and in identifying the underlying mechanisms. Results from recent studies support the hypotheses that learning occurs in both the cerebellar nucleus and cortex, and that th...

journal_title：Current opinion in neurobiology

authors： Medina JF,Nores WL,Ohyama T,Mauk MD

更新日期：2000-12-01 00:00:00

abstract：:Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...

journal_title：Current opinion in neurobiology

authors： Hasson T,Mooseker MS

更新日期：1997-10-01 00:00:00

abstract：:The analysis of complex human diseases has been spurred by the number of published genomic sequence variants - many identified in the course of sequencing the human genome. But, to be useful for genetic analysis, variants have to be mapped accurately, their frequencies in various populations determined, and automated ...

journal_title：Current opinion in neurobiology

authors： Nowotny P,Kwon JM,Goate AM

更新日期：2001-10-01 00:00:00

abstract：:Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

journal_title：Current opinion in neurobiology

authors： Lüningschrör P,Sendtner M

更新日期：2018-08-01 00:00:00

abstract：:Despite considerable effort over a century and the benefit of remarkable technical advances in the past few decades, we are still far from understanding mammalian cerebral neocortex. With its six layers, modular architecture, canonical circuits, innumerable cell types, and computational complexity, isocortex remains a...

journal_title：Current opinion in neurobiology

authors： Fournier J,Müller CM,Laurent G

更新日期：2015-04-01 00:00:00

abstract：:Delineating the lineage of neural cells that captures the progressive steps in their specification is fundamental to understanding brain development, organization, and function. Since the earliest days of embryology, lineage questions have been addressed with methods of increasing specificity, capacity, and resolution...

journal_title：Current opinion in neurobiology

authors： Ma J,Shen Z,Yu YC,Shi SH

更新日期：2018-06-01 00:00:00

abstract：:This review connects several lines of research to argue that hyperbolic geometry should be broadly applicable to neural circuits as well as other biological circuits. The reason for this is that networks that conform to hyperbolic geometry are maximally responsive to external and internal perturbations. These networks...

journal_title：Current opinion in neurobiology

authors： Sharpee TO

更新日期：2019-10-01 00:00:00

abstract：:The cadherin superfamily is a large (now more than 100 proteins) protein family originally identified as cell adhesion molecules. Each cadherin shows distinct expression patterns in the nervous system, and their expressions are both spatially and temporally regulated and diverse among different species. Mounting evide...

journal_title：Current opinion in neurobiology

authors： Matsunaga E,Okanoya K

更新日期：2014-10-01 00:00:00

abstract：:Neuroeconomics is an interdisciplinary field, crossing boundaries between Economics, Psychology, and Neuroscience. Its original program was to provide a test for a large number of competitive theories of decision making. It has in part realized this program, and we review the main findings here. But its results are al...

journal_title：Current opinion in neurobiology

authors： Rustichini A

更新日期：2009-12-01 00:00:00

abstract：:The adult mammalian neocortex, the major region of the cerebral cortex, is divided into functionally specialized areas, defined by distinct architecture and axonal connections. Extrinsic influences, such as thalamocortical input, and genetic regulation, intrinsic to the dorsal telencephalon, control the gradual emerge...

journal_title：Current opinion in neurobiology

authors： O'Leary DD,Nakagawa Y

更新日期：2002-02-01 00:00:00

abstract：:The analysis of stimulus/response patterns using information theoretic approaches requires the full probability distribution of stimuli and response. Recent progress in using information-based tools to understand circuit function has advanced understanding of neural coding at the single cell and population level. In a...

journal_title：Current opinion in neurobiology

authors： Fairhall A,Shea-Brown E,Barreiro A

更新日期：2012-08-01 00:00:00

abstract：:Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...

journal_title：Current opinion in neurobiology

authors： Champagne FA,Curley JP

更新日期：2005-12-01 00:00:00

abstract：:Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a...

journal_title：Current opinion in neurobiology

authors： Filbin MT

更新日期：1995-10-01 00:00:00

abstract：:Modulation of local protein synthesis in neuronal dendrites plays a key role in the production of long-term, activity-dependent changes in synapse structure and functional efficacy. Such long-term changes also require regulation of actin dynamics in dendritic spines. Recent evidence couples local protein synthesis to ...

journal_title：Current opinion in neurobiology

authors： Bramham CR

更新日期：2008-10-01 00:00:00

abstract：:Perception, action, cognition, and emotion can now be mapped in the brain by a growing family of techniques. Positron emission tomography, functional magnetic resonance imaging, event-related electrical potentials, event-related magnetic fields, and other non-invasive imaging techniques are rapidly evolving and provid...

journal_title：Current opinion in neurobiology

authors： Fox PT,Woldorff MG

更新日期：1994-04-01 00:00:00

abstract：:Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific 'labeled-lines' to multimodal...

journal_title：Current opinion in neurobiology

authors： Bokiniec P,Zampieri N,Lewin GR,Poulet JF

更新日期：2018-10-01 00:00:00

abstract：:The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabin...

journal_title：Current opinion in neurobiology

authors： Maldonado R,Robledo P,Berrendero F

更新日期：2013-08-01 00:00:00

abstract：:One of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), serves as a retrograde messenger at various types of synapses throughout the brain. Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neuro...

journal_title：Current opinion in neurobiology

authors： Ohno-Shosaku T,Kano M

更新日期：2014-12-01 00:00:00

abstract：:The Drosophila visual system offers an excellent opportunity for studying the development of proper retinotopic connections at the level of individual identifiable cell types. Recent work suggests that, despite obvious anatomical and developmental differences, at least some of the general developmental strategies oper...

journal_title：Current opinion in neurobiology

authors： Kunes S,Steller H

更新日期：1993-02-01 00:00:00

abstract：:Sensory neurons are usually described with an encoding model, for example, a function that predicts their response from the sensory stimulus using a receptive field (RF) or a tuning curve. However, central to theories of sensory processing is the notion of 'efficient coding'. We argue here that efficient coding implie...

journal_title：Current opinion in neurobiology

authors： Deneve S,Chalk M

更新日期：2016-04-01 00:00:00

abstract：:Sensory gating mechanisms are deployed during vertebrate locomotion to ensure that adaptive and appropriate motor responses to afferent input occur during all phases of the movement cycle. Recent animal studies on the integration of cutaneous information have investigated the roles of interneurones in sensory gating. ...

journal_title：Current opinion in neurobiology

authors： Sillar KT

更新日期：1991-12-01 00:00:00

abstract：:The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glutamate in the synaptic cleft does not attain levels previously suggested. In con...

journal_title：Current opinion in neurobiology

authors： Bergles DE,Diamond JS,Jahr CE

更新日期：1999-06-01 00:00:00

abstract：:Genetically encoded sensors of neural activity enable visualization of circuit-level function in the central nervous system. Although our understanding of the molecular events that regulate neuronal firing, synaptic function, and plasticity has expanded rapidly over the past 15 years, an appreciation for how cellular ...

journal_title：Current opinion in neurobiology

authors： Barth AL

更新日期：2007-10-01 00:00:00

abstract：:Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...

journal_title：Current opinion in neurobiology

authors： Mišić B,Sporns O

更新日期：2016-10-01 00:00:00

abstract：:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...

journal_title：Current opinion in neurobiology

authors： Ting JT,Feng G

更新日期：2011-12-01 00:00:00

abstract：:Acetylcholine is the specific chemical code of spinal nerve terminal transmission at the mammalian neuromuscular junction (NMJ), whereas nicotinic acetylcholine receptors inserted into the membrane of muscle fibres mediate signalling for the muscle response. Glutamate has a primary role in neuromuscular transmission o...

journal_title：Current opinion in neurobiology

authors： Pizzi M,Brunelli G,Barlati S,Spano P

更新日期：2006-06-01 00:00:00

abstract：:We present recent literature on model-based approaches to estimating functional connectivity from neuroimaging data. In contrast to the typical focus on a particular scientific question, we reframe a wider literature in terms of the underlying statistical model used. We distinguish between directed versus undirected a...

journal_title：Current opinion in neurobiology

authors： Foti NJ,Fox EB

更新日期：2019-04-01 00:00:00

abstract：:The importance of the medial temporal lobe to episodic memory has been recognized for decades. Recent human fMRI findings have begun to delineate the functional roles of different MTL regions, most notably the hippocampus, for the retrieval of episodic memories. Importantly, these studies have also identified a networ...

journal_title：Current opinion in neurobiology

authors： Rugg MD,Vilberg KL

更新日期：2013-04-01 00:00:00

abstract：:The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in...

journal_title：Current opinion in neurobiology

authors： Zhai S,Tanimura A,Graves SM,Shen W,Surmeier DJ

更新日期：2018-02-01 00:00:00