SNP analysis to dissect human traits.

abstract：:Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...

journal_title：Current opinion in neurobiology

authors： Sakurai T

更新日期：2013-10-01 00:00:00

abstract：:Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differe...

journal_title：Current opinion in neurobiology

authors： Temple S,Qian X

更新日期：1996-02-01 00:00:00

abstract：:Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring. In this review, w...

journal_title：Current opinion in neurobiology

authors： Nugent AA,Kolpak AL,Engle EC

更新日期：2012-10-01 00:00:00

abstract：:A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...

journal_title：Current opinion in neurobiology

authors： Carney LH

更新日期：1999-08-01 00:00:00

abstract：:The idea that visual signals relayed by the parvocellular and magnocellular subdivisions of the lateral geniculate nucleus remain segregated in the cerebral cortex has attracted considerable attention. It has been proposed that parvocellular contributions dominate in the temporal visual cortex, and that magnocellular ...

journal_title：Current opinion in neurobiology

authors： Maunsell JH

更新日期：1992-08-01 00:00:00

abstract：:Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

journal_title：Current opinion in neurobiology

authors： Hernik M,Csibra G

更新日期：2009-02-01 00:00:00

abstract：:The vestibular system provides an attractive model for understanding how changes in cellular and synaptic activity influence learning and memory in a quantifiable behavior, the vestibulo-ocular reflex. The vestibulo-ocular reflex produces eye movements that compensate for head motion; simple yet powerful forms of moto...

journal_title：Current opinion in neurobiology

authors： Gittis AH,du Lac S

更新日期：2006-08-01 00:00:00

abstract：:Cortical networks receive a highly variable stream of inputs from internal and external influences, and must flexibly adapt their operations on a short timescale. Recent work has highlighted this state-dependent functional flexibility of cortical circuits and provided initial insights into underlying circuit-level mec...

journal_title：Current opinion in neurobiology

authors： Cardin JA

更新日期：2019-10-01 00:00:00

abstract：:Parenting is essential for survival and wellbeing in many species. Since it can be performed with little prior experience and entails considerable sacrifices without immediate benefits for the caregiver, this behavior is likely orchestrated by evolutionarily shaped, hard-wired neural circuits. At the same time, experi...

journal_title：Current opinion in neurobiology

authors： Kohl J

更新日期：2020-02-01 00:00:00

abstract：:It has been suggested that many aspects of reward-guided behaviour can be understood within the framework of a computational account of decision making. The account emphasises representation of expectations about decision outcomes and the revision of future expectations in the light of the prediction error-the discrep...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Mars RB,Summerfield C

更新日期：2009-02-01 00:00:00

abstract：:The issue of whether encoding of geometric information for navigational purposes crucially depends on environmental experience or whether it is innately predisposed in the brain has been recently addressed in controlled rearing studies. Non-human animals can make use of the geometric shape of an environment for spatia...

journal_title：Current opinion in neurobiology

authors： Vallortigara G,Sovrano VA,Chiandetti C

更新日期：2009-02-01 00:00:00

abstract：:Recent work on the retinotectal projection clearly establishes the roles of neuronal activity and position-based cues in the patterning of nerve connections. In some species, the high degree of spatial order has been shown to emerge from a continued process of terminal growth and refinement. The future challenge is no...

journal_title：Current opinion in neurobiology

authors： Fraser SE

更新日期：1992-02-01 00:00:00

abstract：:The mechanisms for delivering components to nerve terminals are diverse and highly regulated. The diversity of kinesin motors alone is insufficient to account for the specificity of delivery. Additional specificity and control are contributed by adaptor proteins and associated regulatory molecules. The interaction of ...

journal_title：Current opinion in neurobiology

authors： Goldstein AY,Wang X,Schwarz TL

更新日期：2008-10-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) and adjacent areas of the medial frontal cortex (MFC) have been implicated in monitoring behaviour and in detecting errors. Recent evidence, however, suggests that the ACC not only registers the occurrence of errors but also represents other aspects of the reinforcement history that...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Buckley MJ,Behrens TE,Walton ME,Bannerman DM

更新日期：2007-04-01 00:00:00

abstract：:Trans-synaptic interactions organize the multiple steps of synaptic development and are critical to generate fully functional neuronal circuits. While trans-synaptic interactions are primarily mediated by cell adhesion molecules (CAMs), some directly involve ionotropic glutamate receptors (iGluRs). Here, we review the...

journal_title：Current opinion in neurobiology

authors： Fossati M,Charrier C

更新日期：2020-10-29 00:00:00

abstract：:The neuropeptide oxytocin has had key roles throughout mammalian evolution in the regulation of complex social cognition and behaviors, such as attachment, parental care, pair-bonding, as well as social exploration and recognition. Recently, studies have begun to provide evidence that the function of this neuropeptide...

journal_title：Current opinion in neurobiology

authors： Kumsta R,Heinrichs M

更新日期：2013-02-01 00:00:00

abstract：:Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are p...

journal_title：Current opinion in neurobiology

authors： Zufall F,Shepherd GM,Barnstable CJ

更新日期：1997-06-01 00:00:00

abstract：:Comparative studies over the past year have revealed two new insights into the role of neuropeptides in the evolution of social behaviors. First, across vertebrate taxa, certain neuropeptide effects appear to be gender-specific. Second, species variations in receptor gene structure can alter neuropeptide receptor dist...

journal_title：Current opinion in neurobiology

authors： Insel TR,Young LJ

更新日期：2000-12-01 00:00:00

abstract：:Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...

journal_title：Current opinion in neurobiology

authors： Mišić B,Sporns O

更新日期：2016-10-01 00:00:00

abstract：:Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific 'labeled-lines' to multimodal...

journal_title：Current opinion in neurobiology

authors： Bokiniec P,Zampieri N,Lewin GR,Poulet JF

更新日期：2018-10-01 00:00:00

abstract：:Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...

journal_title：Current opinion in neurobiology

authors： Kording KP

更新日期：2014-04-01 00:00:00

abstract：:Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...

journal_title：Current opinion in neurobiology

authors： Wilsch-Bräuninger M,Florio M,Huttner WB

更新日期：2016-08-01 00:00:00

abstract：:Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cy...

journal_title：Current opinion in neurobiology

authors： Jentsch TJ

更新日期：1996-06-01 00:00:00

abstract：:Plasma membrane neurotransmitter transporters for monoamines, GABA, glycine and excitatory amino acids are homologous to two sizable families of bacterial amino acid transporters. Recently, a high resolution structure was determined for a thermophilic glutamate transporter. Also, a bacterial tryptophan transporter rel...

journal_title：Current opinion in neurobiology

authors： Sonders MS,Quick M,Javitch JA

更新日期：2005-06-01 00:00:00

abstract：:A critical review of the role of the cerebellum in motor learning is presented. Specifically, the hypothesis that the climbing fibers that issue from the inferior olive serve to modify the responsiveness of cerebellar Purkinje cells is evaluated. It is concluded that there is no convincing evidence, at this time, to s...

journal_title：Current opinion in neurobiology

authors： Llinás R,Welsh JP

更新日期：1993-12-01 00:00:00

abstract：:Both mammals and birds can flexibly organize their behavior over time. In mammals, the mental operations generating this ability are called executive functions and are associated with the prefrontal cortex. The corresponding structure in birds is the nidopallium caudolaterale. Anatomical, neurochemical, electrophysiol...

journal_title：Current opinion in neurobiology

authors： Güntürkün O

更新日期：2005-12-01 00:00:00

abstract：:Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...

journal_title：Current opinion in neurobiology

authors： Champagne FA,Curley JP

更新日期：2005-12-01 00:00:00

abstract：:Here we review the mechanisms that determine projection neuron identity during cortical development. Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the upper layers of the cortex, and subcortical projection neur...

journal_title：Current opinion in neurobiology

authors： Leone DP,Srinivasan K,Chen B,Alcamo E,McConnell SK

更新日期：2008-02-01 00:00:00

abstract：:The circuitry mediating the integration of reward perception and adaptive behavioral responses has been further refined. Recent developments indicate that the nucleus accumbens has a primary role in motivational circuitry, whereas afferents to the nucleus accumbens, in part, subserve distinct functions. Dopaminergic a...

journal_title：Current opinion in neurobiology

authors： Kalivas PW,Nakamura M

更新日期：1999-04-01 00:00:00

abstract：:Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lea...

journal_title：Current opinion in neurobiology

authors： Wang C,Telpoukhovskaia MA,Bahr BA,Chen X,Gan L

更新日期：2018-02-01 00:00:00