Abstract：
:Here we review the mechanisms that determine projection neuron identity during cortical development. Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the upper layers of the cortex, and subcortical projection neurons, which are found in the deep layers. Early progenitor cells in the ventricular zone produce deep layer neurons that express transcription factors including Sox5, Fezf2, and Ctip2, which play important roles in the specification of subcortically projecting axons. Upper layer neurons are produced from progenitors in the subventricular zone, and the expression of Satb2 in these differentiating neurons is required for the formation of axonal projections that connect the two cerebral hemispheres. The Fezf2/Ctip2 and Satb2 pathways appear to be mutually repressive, thus ensuring that individual neurons adopt either a subcortical or callosal projection neuron identity at early times during development. The molecular mechanisms by which Satb2 regulates gene expression involves long-term epigenetic changes in chromatin configuration, which may enable cell fate decisions to be maintained during development.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Leone DP,Srinivasan K,Chen B,Alcamo E,McConnell SKdoi
10.1016/j.conb.2008.05.006subject
Has Abstractpub_date
2008-02-01 00:00:00pages
28-35issue
1eissn
0959-4388issn
1873-6882pii
S0959-4388(08)00034-2journal_volume
18pub_type
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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journal_title：Current opinion in neurobiology
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