Abstract:
:AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the tightly regulated trafficking of AMPARs into and out of synapses. The life cycle of AMPARs from their biosynthesis, membrane trafficking, and synaptic targeting to their degradation are controlled by a series of orchestrated interactions with numerous intracellular regulatory proteins. Here we review recent progress made toward the understanding the regulation of AMPAR trafficking, focusing on the roles of several key intracellular AMPAR interacting proteins.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Anggono V,Huganir RLdoi
10.1016/j.conb.2011.12.006subject
Has Abstractpub_date
2012-06-01 00:00:00pages
461-9issue
3eissn
0959-4388issn
1873-6882pii
S0959-4388(11)00224-8journal_volume
22pub_type
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