Neuronal plasticity and cellular immunity: shared molecular mechanisms.

Abstract:

:It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.

journal_name

Curr Opin Neurobiol

authors

Boulanger LM,Huh GS,Shatz CJ

doi

10.1016/s0959-4388(00)00251-8

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

568-78

issue

5

eissn

0959-4388

issn

1873-6882

pii

S0959-4388(00)00251-8

journal_volume

11

pub_type

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