Abstract:
:It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central nervous system, demonstrating that molecules can perform critical roles in both systems. Recent studies reveal striking parallels between cellular signaling mechanisms in the immune and nervous systems that may provide unexpected insights into the development, function, and diseases of both systems.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Boulanger LM,Huh GS,Shatz CJdoi
10.1016/s0959-4388(00)00251-8subject
Has Abstractpub_date
2001-10-01 00:00:00pages
568-78issue
5eissn
0959-4388issn
1873-6882pii
S0959-4388(00)00251-8journal_volume
11pub_type
杂志文章,评审abstract::Helping involves other-oriented actions that have the potential to benefit another. The last ten years has seen the introduction of several experimental paradigms to study helping in rats. In the best characterized of these, a free rat opens a door to release a rat trapped in an acrylic tube or pool of water. Helping ...
journal_title:Current opinion in neurobiology
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abstract::Sexual communication can evolve in response to sexual selection, and it can also cause behavioral reproductive isolation between populations and thus drive speciation. Anurans are an excellent system to investigate these links between behavior and evolution because we have detailed knowledge of how neural mechanisms g...
journal_title:Current opinion in neurobiology
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abstract::Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurolo...
journal_title:Current opinion in neurobiology
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abstract::Visual perception is inherently statistical: brains exploit repeating features of natural scenes to disambiguate images that could, in principle, have many causes. A clear case for the relevance of statistical inference in vision is animal camouflage. Although visual scenes are each composed of unique arrangements of ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.10.010
更新日期:2020-02-01 00:00:00
abstract::The impact of microarray studies on neurobiology has been limited because, with the exception of a few outstanding papers, most reports provide little more than lists of genes, often leaving the reader at a loss to understand which and how many of the identified transcripts will be true positives with significant biol...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00107-7
更新日期:2003-10-01 00:00:00
abstract::The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in...
journal_title:Current opinion in neurobiology
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abstract::Animal life is rhythmic. Here we provide an overview of various rhythmic behaviors, connected environmental factors and endogenous mechanisms. We not only cover terrestrial species, but also highlight aquatic environments with typically complex interconnected rhythms. We further address diel, seasonal and potential lu...
journal_title:Current opinion in neurobiology
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abstract::The nervous system is evolutionarily conservative compared to the peripheral appendages that it controls. However, species-specific behaviors may have arisen from very small changes in neuronal circuits. In particular, changes in neuromodulatory systems may allow multifunctional circuits to produce different sets of b...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
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更新日期:1994-10-01 00:00:00
abstract::Visual attention operates by biasing competitive interactions between neural representations, favoring relevant over irrelevant visual inputs. Attention can enhance the processing of relevant information using location-based, feature-based or object-based selection mechanisms. Studies using event-related potential and...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.03.008
更新日期:2005-04-01 00:00:00
abstract::Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable neuroengineering capabilities. In this review, we provide an accessible primer ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.06.008
更新日期:2019-10-01 00:00:00
abstract::Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.04.003
更新日期:2008-02-01 00:00:00
abstract::Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::Understanding how the brain performs computations requires understanding neuronal firing patterns at successive levels of processing-a daunting and seemingly intractable task. Two recent studies have made dramatic progress on this problem by showing how its dimensionality can be reduced. Using the retina as a model sy...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2007.07.002
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abstract::The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology. Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses hav...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80088-2
更新日期:1996-10-01 00:00:00
abstract::Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper und...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(99)80017-8
更新日期:1999-02-01 00:00:00
abstract::Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.02.021
更新日期:2018-08-01 00:00:00
abstract::Converging evidence indicates that primates have a distinct cortical image of homeostatic afferent activity that reflects all aspects of the physiological condition of all tissues of the body. This interoceptive system, associated with autonomic motor control, is distinct from the exteroceptive system (cutaneous mecha...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:2003-08-01 00:00:00
abstract::Biological systems use internal circadian clocks to efficiently organize physiological and behavioral activity within the 24-hour time domain. In the absence of time cues, circadian periods vary slightly from 24 hours, but in nature, ambient light serves as the most salient synchronizer for these rhythms, fine-tuning ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2003.10.011
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abstract::Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.10.013
更新日期:2004-12-01 00:00:00
abstract::Activity in cortical networks is heterogeneous, sparse and often precisely timed. The functional significance of sparseness and precise spike timing is debated, but our understanding of the developmental and synaptic mechanisms that shape neuronal discharge patterns has improved. Evidence for highly specialized, selec...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.03.006
更新日期:2010-06-01 00:00:00
abstract::Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/S0959-4388(99)80066-X
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abstract::Proteoglycans are ubiquitous cell-surface and secreted glycoproteins that are involved in diverse cellular behaviors. The identities of several nervous system proteoglycans, including many of the major species in the mammalian brain, have recently come to light. In addition, recent studies have given new insights into...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::The Drosophila visual system offers an excellent opportunity for studying the development of proper retinotopic connections at the level of individual identifiable cell types. Recent work suggests that, despite obvious anatomical and developmental differences, at least some of the general developmental strategies oper...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that po...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.01.014
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abstract::A novel multigene family has been identified that is likely to encode odorant receptors on olfactory sensory neurons. Further studies on this gene family are likely to shed light on the molecular mechanisms underlying information coding in the mammalian olfactory system. This review is also published in Current Opinio...
journal_title:Current opinion in neurobiology
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