Abstract:
:Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that positively and negatively regulate thirst. The next step forward would be to elucidate how neural populations interact with each other to control drinking behavior.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Ichiki T,Augustine V,Oka Ydoi
10.1016/j.conb.2019.01.014subject
Has Abstractpub_date
2019-08-01 00:00:00pages
134-140eissn
0959-4388issn
1873-6882pii
S0959-4388(19)30012-1journal_volume
57pub_type
杂志文章,评审abstract::Classical conditioning, the simplest form of associative learning, is one of the most studied paradigms in behavioural psychology. Since the formal description of classical conditioning by Pavlov, lesion studies in animals have identified a number of anatomical structures involved in, and necessary for, classical cond...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00078-7
更新日期:2000-04-01 00:00:00
abstract::Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.09.006
更新日期:2012-06-01 00:00:00
abstract::The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.05.002
更新日期:2008-02-01 00:00:00
abstract::Developing axons appear to navigate to their targets partly in response to long-range diffusible chemoattractants secreted by target cells. The past year has seen the identification of the first target-derived attractants for developing axons, the netrins. Target-derived diffusible factors have also been implicated in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(95)80091-3
更新日期:1995-02-01 00:00:00
abstract::The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.03.011
更新日期:2010-08-01 00:00:00
abstract::The molecular cloning of components involved in the cAMP second messenger cascade has allowed their biochemical characterization and revealed properties that are important for their role in sensory transduction. Recent evidence suggests inositol 1,4,5-trisphosphate functions as an additional second messenger in olfact...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(91)90079-m
更新日期:1991-08-01 00:00:00
abstract::Perceptual and control systems are tasked with the challenge of accurately and efficiently estimating the dynamic states of objects in the environment. To properly account for uncertainty, it is necessary to maintain a dynamical belief state representation rather than a single state vector. In this review, canonical a...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.01.018
更新日期:2014-04-01 00:00:00
abstract::Recent studies show that anatomical and functional brain networks exhibit similar small-world properties. However, the networks that are compared often differ in what the nodes represent (e.g. sensors or brain areas), what kind of connectivity is measured, and what temporal and spatial scales are probed. Here, I revie...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2007.03.008
更新日期:2007-04-01 00:00:00
abstract::The Drosophila visual system offers an excellent opportunity for studying the development of proper retinotopic connections at the level of individual identifiable cell types. Recent work suggests that, despite obvious anatomical and developmental differences, at least some of the general developmental strategies oper...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(93)90035-w
更新日期:1993-02-01 00:00:00
abstract::The biochemical basis of circadian timekeeping is best characterized in cyanobacteria. The structures of its key molecular players, KaiA, KaiB, and KaiC are known and these proteins can reconstitute a remarkable circadian oscillation in a test tube. KaiC is rhythmically phosphorylated and its phospho-status is a marke...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.02.012
更新日期:2013-10-01 00:00:00
abstract::Increasingly systematic approaches to quantifying receptive fields in primary visual cortex, combined with inspired ideas about functional circuitry, non-linearities, and visual stimuli, are bringing new interest to classical problems. This includes the distinction and hierarchy between simple and complex cells, the m...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.07.006
更新日期:2005-08-01 00:00:00
abstract::Almost 30 years ago, actin was identified as the major cytoskeletal component of dendritic spines. Since then, its role in the remarkable dynamics of spine morphology have been detailed with live-cell views establishing that spine shape dynamics are an important requirement for synaptogenesis and synaptic plasticity. ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.06.009
更新日期:2010-10-01 00:00:00
abstract::Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton. Ankyrin g...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2021.01.002
更新日期:2021-01-20 00:00:00
abstract::The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabin...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章
doi:10.1016/j.conb.2013.02.004
更新日期:2013-08-01 00:00:00
abstract::The analysis of stimulus/response patterns using information theoretic approaches requires the full probability distribution of stimuli and response. Recent progress in using information-based tools to understand circuit function has advanced understanding of neural coding at the single cell and population level. In a...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2012.06.005
更新日期:2012-08-01 00:00:00
abstract::Ambiguous figures that may take on the appearance of two or more distinct forms have fascinated philosophers and psychologists for generations. Recently, several laboratories have studied the neuronal basis of perceptual appearance at the level of single neurons in the cerebral cortex. Experiments that integrate neuro...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00099-0
更新日期:2003-08-01 00:00:00
abstract::Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spe...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.12.009
更新日期:2016-06-01 00:00:00
abstract::Rats sweep their vibrissae through space to locate objects in their immediate environment. In essence, their view of the proximal world is generated through pliable hairs that tap and palpate objects. The texture and shape of those objects must be discerned for the rat to assess the value of the object. Furthermore, t...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2006.06.009
更新日期:2006-08-01 00:00:00
abstract::Coupled oscillations are hypothesized to organize the processing of information across distributed brain circuits. This idea is supported by recent evidence, and newly developed techniques promise to put such theoretical framework to mechanistic testing. We review evidence suggesting that individual oscillatory cycles...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.12.011
更新日期:2015-04-01 00:00:00
abstract::Unravelling the mechanisms of learning and memory can, and should, be tackled at many levels. Discovery of the huge family of odourant receptor genes provided olfaction with 'molecular' respectability similar to that afforded to the visual system. Consequently, molecular studies have dominated the olfactory literature...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(95)80009-3
更新日期:1995-08-01 00:00:00
abstract::Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny. An update of these models is clearly timely, taking into consideration not only changes in neuronal discharge rates, b...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80024-9
更新日期:1996-12-01 00:00:00
abstract::Major technical advances in the imaging of live cells have led to a recent flurry of studies demonstrating how dendrites remodel dynamically during development. Taken together with our current understanding of axonal development, these studies help provide a more unified picture of how neural circuits might be formed ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(99)00059-8
更新日期:2000-02-01 00:00:00
abstract::The study of plasticity in the central nervous system is a major and very dynamic neuroscience research field with enormous clinical potential. Considerable advances in this field have been made during the past 10 years. It now appears that most circuits in the brain and spinal cord show plasticity and that they can b...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.10.009
更新日期:2004-12-01 00:00:00
abstract::Cellular processes that mediate learning and memory show a remarkable level of conservation between vertebrates and invertebrates. Recent studies have shown that learning and memory formation in invertebrates, so-called 'simple systems', involves a highly complex arrangement of cellular pathways. Some pathways contrib...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(01)00281-1
更新日期:2001-12-01 00:00:00
abstract::Neurons have a multiplicity of ionic conductance mechanisms, the interactions of which determine in part the response of a neuron to chemical and electrical synaptic interactions, firing patterns, excitability, membrane potential and action-potential waveform. Several papers published in the past year have provided im...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(91)90017-2
更新日期:1991-06-01 00:00:00
abstract::Not only is the sense of smell of pivotal importance to most animals but also serves as a significant model system in biological research. In recent years, great strides in our understanding of how the olfactory system is organized and operates have been made. Instrumental in these efforts has been work performed in D...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.02.006
更新日期:2015-10-01 00:00:00
abstract::Sex differences in the nervous system are found throughout the animal kingdom. Here, we discuss three prominent genetic models: nematodes, fruit flies, and mice. In all three, differential cell death is central to sexual differentiation and shared molecular mechanisms have been identified. Our knowledge of the precise...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.09.006
更新日期:2010-12-01 00:00:00
abstract::The view of cerebellar functions has been extended from controlling sensorimotor processes to processing 'contextual' information and generating predictions for a diverse range of behaviors. These functions rely on the computation of the local cerebellar microcircuits and long-range connectivity that relays cerebellar...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.12.016
更新日期:2018-02-01 00:00:00
abstract::Tight control of developmental timing is pivotal to many major processes in developmental biology, such as patterning, fate specification, cell cycle dynamics, cell migration and connectivity. Temporal change in these ontogenetic sequences is known as heterochrony, a major force in the evolution of body plans and orga...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.12.008
更新日期:2017-02-01 00:00:00
abstract::AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.12.006
更新日期:2012-06-01 00:00:00