Guidance and induction of branch formation in developing axons by target-derived diffusible factors.

abstract：:Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...

journal_title：Current opinion in neurobiology

authors： Guardia CM,De Pace R,Mattera R,Bonifacino JS

更新日期：2018-08-01 00:00:00

abstract：:Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelect...

journal_title：Current opinion in neurobiology

authors： Scaini D,Ballerini L

更新日期：2018-06-01 00:00:00

abstract：:In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of f...

journal_title：Current opinion in neurobiology

authors： Villemagne VL,Okamura N

更新日期：2016-02-01 00:00:00

abstract：:Inhibitory molecules in CNS myelin affect axonal regeneration after injury. In the past year, myelin-associated glycoprotein (MAG), a well-characterized myelin protein, has been identified as an inhibitor of axonal regeneration. This finding, together with its established ability to promote outgrowth, defines MAG as a...

journal_title：Current opinion in neurobiology

authors： Filbin MT

更新日期：1995-10-01 00:00:00

abstract：:The glial regulation of synaptic function provides important modulation of the synaptic and behavioral changes induced by drugs of abuse. In some cases, this regulation is adaptive, reducing drug-induced change, and in other cases maladaptive, contributing to the induction or maintenance of these changes. Understandin...

journal_title：Current opinion in neurobiology

authors： Stellwagen D,Kemp GM,Valade S,Chambon J

更新日期：2019-08-01 00:00:00

abstract：:Neuroscientists spent decades debating whether synaptic plasticity was presynaptically or postsynaptically expressed. It was eventually concluded that plasticity depends on many factors, including cell type. More recently, it has become increasingly clear that plasticity is regulated at an even finer grained level; it...

journal_title：Current opinion in neurobiology

authors： Larsen RS,Sjöström PJ

更新日期：2015-12-01 00:00:00

abstract：:The impact of microarray studies on neurobiology has been limited because, with the exception of a few outstanding papers, most reports provide little more than lists of genes, often leaving the reader at a loss to understand which and how many of the identified transcripts will be true positives with significant biol...

journal_title：Current opinion in neurobiology

authors： Henry GL,Zito K,Dubnau J

更新日期：2003-10-01 00:00:00

abstract：:Many constituents of Wnt signaling pathways are expressed in the developing and mature nervous systems. Recent work has shown that Wnt signaling controls initial formation of the neural plate and many subsequent patterning decisions in the embryonic nervous system, including formation of the neural crest. Wnt signalin...

journal_title：Current opinion in neurobiology

authors： Patapoutian A,Reichardt LF

更新日期：2000-06-01 00:00:00

abstract：:Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals t...

journal_title：Current opinion in neurobiology

authors： Llorens-Bobadilla E,Martin-Villalba A

更新日期：2017-02-01 00:00:00

abstract：:Neural oscillations are ubiquitous in olfactory systems of mammals, insects and molluscs. Neurophysiological and computational investigations point to common mechanisms for gamma or odor associated oscillations across phyla (40-100Hz in mammals, 20-30Hz in insects, 0.5-1.5Hz in molluscs), engaging the reciprocal dendr...

journal_title：Current opinion in neurobiology

authors： Kay LM

更新日期：2015-04-01 00:00:00

abstract：:Accurate neural crest cell (NCC) migration requires tight control of cell adhesions, cytoskeletal dynamics and cell motility. Cadherins and RhoGTPases are critical molecular players that regulate adhesions and motility during initial delamination of NCCs from the neuroepithelium. Recent studies have revealed multiple ...

journal_title：Current opinion in neurobiology

authors： Clay MR,Halloran MC

更新日期：2011-02-01 00:00:00

abstract：:Accepting, rejecting or modifying the many different theories of the cerebellum's role in the control of movement requires an understanding of the signals encoded in the discharge of cerebellar neurons and how those signals are transformed by the cerebellar circuitry. Particularly challenging is understanding the sens...

journal_title：Current opinion in neurobiology

authors： Ebner TJ

更新日期：1998-12-01 00:00:00

abstract：:Here I review the diversity of GABAergic neurons in the rodent basolateral amygdala (BLA). In spite of the recent identification of the role played by certain neurons of BLA in learning and memory of fear, the diversity of GABAergic neurons has not been fully explored. I describe analogies and differences between GABA...

journal_title：Current opinion in neurobiology

authors： Capogna M

更新日期：2014-06-01 00:00:00

abstract：:Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...

journal_title：Current opinion in neurobiology

authors： Tillery SI,Taylor DM

更新日期：2004-12-01 00:00:00

abstract：:The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...

journal_title：Current opinion in neurobiology

authors： Zhong W,Chia W

更新日期：2008-02-01 00:00:00

abstract：:The involvement of the endocannabinoid system in drug addiction was initially studied by the use of compounds with different affinities for each cannabinoid receptor or for the proteins involved in endocannabinoids inactivation. The generation of genetically modified mice with selective mutations in these endocannabin...

journal_title：Current opinion in neurobiology

authors： Maldonado R,Robledo P,Berrendero F

更新日期：2013-08-01 00:00:00

abstract：:Animal eyes have long served as a classical example of independent origin followed by convergence of structures onto a few different solutions. During the past decade this view has been challenged by the discovery of shared developmental regulatory genes. The Pax6 gene in particular is almost universally employed for ...

journal_title：Current opinion in neurobiology

authors： Nilsson DE

更新日期：2004-08-01 00:00:00

abstract：:Recent work on the retinotectal projection clearly establishes the roles of neuronal activity and position-based cues in the patterning of nerve connections. In some species, the high degree of spatial order has been shown to emerge from a continued process of terminal growth and refinement. The future challenge is no...

journal_title：Current opinion in neurobiology

authors： Fraser SE

更新日期：1992-02-01 00:00:00

abstract：:Central core (brainstem, diencephalic and basal forebrain) systems influence the functional modes of thalamic and cortical neurons during behavioral states of vigilance. Recent studies in vivo and in vitro have focused on the cellular properties of central core systems and their modulation of slow sleep oscillations, ...

journal_title：Current opinion in neurobiology

authors： Steriade M

更新日期：1993-08-01 00:00:00

abstract：:Recent functional brain imaging studies of the neurobiology of emotion have investigated how individual differences among subjects modulate neural responses during emotion processing. Differences in personality, dispositional affect, biological sex, and genotype can all substantially modulate the neural bases of emoti...

journal_title：Current opinion in neurobiology

authors： Hamann S,Canli T

更新日期：2004-04-01 00:00:00

abstract：:The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complet...

journal_title：Current opinion in neurobiology

authors： Sasaki T,Leutgeb S,Leutgeb JK

更新日期：2015-06-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) is used widely to determine the spatial layout of brain activation associated with specific cognitive tasks at a spatial scale of millimeters. Recent methodological improvements have made it possible to determine the latency and temporal structure of the activation at a tem...

journal_title：Current opinion in neurobiology

authors： Formisano E,Goebel R

更新日期：2003-04-01 00:00:00

abstract：:Cortical networks receive a highly variable stream of inputs from internal and external influences, and must flexibly adapt their operations on a short timescale. Recent work has highlighted this state-dependent functional flexibility of cortical circuits and provided initial insights into underlying circuit-level mec...

journal_title：Current opinion in neurobiology

authors： Cardin JA

更新日期：2019-10-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) and positron emission tomography measure local changes in brain hemodynamics induced by cognitive or perceptual tasks. These measures have a uniformly high spatial resolution of millimeters or less, but poor temporal resolution (about 1s). Conversely, electroencephalography...

journal_title：Current opinion in neurobiology

authors： Dale AM,Halgren E

更新日期：2001-04-01 00:00:00

abstract：:Despite considerable skepticism, researchers have found that the patterns of muscle activation that control feeding behaviors of lower vertebrates have been surprisingly conserved during evolution. This tendency for conservation among taxa appears in the face of marked flexibility of motor patterns within individuals....

journal_title：Current opinion in neurobiology

authors： Wainwright PC

更新日期：2002-12-01 00:00:00

abstract：:Rats sweep their vibrissae through space to locate objects in their immediate environment. In essence, their view of the proximal world is generated through pliable hairs that tap and palpate objects. The texture and shape of those objects must be discerned for the rat to assess the value of the object. Furthermore, t...

journal_title：Current opinion in neurobiology

authors： Kleinfeld D,Ahissar E,Diamond ME

更新日期：2006-08-01 00:00:00

abstract：:Because of new data, anatomical and functional models of the basal ganglia in normal and pathological conditions (e.g. Parkinson's and Huntington's diseases) have recently come under greater scrutiny. An update of these models is clearly timely, taking into consideration not only changes in neuronal discharge rates, b...

journal_title：Current opinion in neurobiology

authors： Wichmann T,DeLong MR

更新日期：1996-12-01 00:00:00

abstract：:The view of cerebellar functions has been extended from controlling sensorimotor processes to processing 'contextual' information and generating predictions for a diverse range of behaviors. These functions rely on the computation of the local cerebellar microcircuits and long-range connectivity that relays cerebellar...

journal_title：Current opinion in neurobiology

authors： Xiao L,Scheiffele P

更新日期：2018-02-01 00:00:00

abstract：:Myelin sheaths in the vertebrate nervous system enable faster impulse propagation, while myelinating glia provide vital support to axons. Once considered a static insulator, converging evidence now suggests that myelin in the central nervous system can be dynamically regulated by neuronal activity and continues to par...

journal_title：Current opinion in neurobiology

authors： Kaller MS,Lazari A,Blanco-Duque C,Sampaio-Baptista C,Johansen-Berg H

更新日期：2017-12-01 00:00:00

abstract：:Research on spatial problem-solving over the past two years has linked the hippocampus to path integration, that is, the use of movement-related cues to guide spatial behavior. Path integration may underlie the forms of place learning that are impaired by hippocampal damage. It remains a challenge to determine whether...

journal_title：Current opinion in neurobiology

authors： Whishaw IQ,McKenna JE,Maaswinkel H

更新日期：1997-04-01 00:00:00