Roles of Wnt proteins in neural development and maintenance.

abstract：:Ca2+ entry into neurons is one of the major effectors of stimulus-induced physiological change. Ca2+ can enter neurons through a number of different voltage-gated and ligand-gated channels. Depending on the route of entry, Ca2+ stimulates distinct intracellular signaling pathways, which activate different sets of gene...

journal_title：Current opinion in neurobiology

authors： Gallin WJ,Greenberg ME

更新日期：1995-06-01 00:00:00

abstract：:Cell fate in the cephalic neural primordium is controlled by an organizer located at the midbrain-hindbrain boundary. Studies in chick, mouse and zebrafish converge to show that mutually repressive interactions between homeodomain transcription factors of the Otx and Gbx class position this organizer in the neural pri...

journal_title：Current opinion in neurobiology

authors： Rhinn M,Brand M

更新日期：2001-02-01 00:00:00

abstract：:Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurolo...

journal_title：Current opinion in neurobiology

authors： Yu CD,Xu QJ,Chang RB

更新日期：2020-06-01 00:00:00

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:Neuroeconomics is an interdisciplinary field, crossing boundaries between Economics, Psychology, and Neuroscience. Its original program was to provide a test for a large number of competitive theories of decision making. It has in part realized this program, and we review the main findings here. But its results are al...

journal_title：Current opinion in neurobiology

authors： Rustichini A

更新日期：2009-12-01 00:00:00

abstract：:Genetically encoded sensors of neural activity enable visualization of circuit-level function in the central nervous system. Although our understanding of the molecular events that regulate neuronal firing, synaptic function, and plasticity has expanded rapidly over the past 15 years, an appreciation for how cellular ...

journal_title：Current opinion in neurobiology

authors： Barth AL

更新日期：2007-10-01 00:00:00

abstract：:Recent technological advances have enabled the use of different optical methods to activate neurons, including 'caged' glutamate, photoactivation of genetically engineered cascades, and direct two-photon excitation. The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the te...

journal_title：Current opinion in neurobiology

authors： Callaway EM,Yuste R

更新日期：2002-10-01 00:00:00

abstract：:The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our under...

journal_title：Current opinion in neurobiology

authors： Benakis C,Martin-Gallausiaux C,Trezzi JP,Melton P,Liesz A,Wilmes P

更新日期：2020-04-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:The neuropeptide oxytocin has had key roles throughout mammalian evolution in the regulation of complex social cognition and behaviors, such as attachment, parental care, pair-bonding, as well as social exploration and recognition. Recently, studies have begun to provide evidence that the function of this neuropeptide...

journal_title：Current opinion in neurobiology

authors： Kumsta R,Heinrichs M

更新日期：2013-02-01 00:00:00

abstract：:Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lea...

journal_title：Current opinion in neurobiology

authors： Wang C,Telpoukhovskaia MA,Bahr BA,Chen X,Gan L

更新日期：2018-02-01 00:00:00

abstract：:GABAergic interneurons in the hippocampus coordinate neuronal activity that gives rise to network oscillations. In this article we present advances in our understanding of how different classes of hippocampal interneurons contribute to distinct hippocampal network oscillations. We focus on two main experimental approa...

journal_title：Current opinion in neurobiology

authors： Allen K,Monyer H

更新日期：2015-04-01 00:00:00

abstract：:The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...

journal_title：Current opinion in neurobiology

authors： Sharpee TO,Calhoun AJ,Chalasani SH

更新日期：2014-04-01 00:00:00

abstract：:Metabotropic L-glutamate receptors are involved in various forms of synaptic plasticity in the hippocampus. The use of a new antagonist (LY341495) that blocks all known metabotropic L-glutamate receptors in the brain, together with subtype-selective antagonists, has identified multiple roles both for cloned and novel ...

journal_title：Current opinion in neurobiology

authors： Bortolotto ZA,Fitzjohn SM,Collingridge GL

更新日期：1999-06-01 00:00:00

abstract：:Sex differences in the nervous system are found throughout the animal kingdom. Here, we discuss three prominent genetic models: nematodes, fruit flies, and mice. In all three, differential cell death is central to sexual differentiation and shared molecular mechanisms have been identified. Our knowledge of the precise...

journal_title：Current opinion in neurobiology

authors： Forger NG,de Vries GJ

更新日期：2010-12-01 00:00:00

abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...

journal_title：Current opinion in neurobiology

authors： Lee MK,Borchelt DR,Wong PC,Sisodia SS,Price DL

更新日期：1996-10-01 00:00:00

abstract：:Our ability to learn and control the motor aspects of complex laryngeal behaviors, such as speech and song, is modulated by the laryngeal motor cortex (LMC), which is situated in the area 4 of the primary motor cortex and establishes both direct and indirect connections with laryngeal motoneurons. In contrast, the LMC...

journal_title：Current opinion in neurobiology

authors： Simonyan K

更新日期：2014-10-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:Major technical advances in the imaging of live cells have led to a recent flurry of studies demonstrating how dendrites remodel dynamically during development. Taken together with our current understanding of axonal development, these studies help provide a more unified picture of how neural circuits might be formed ...

journal_title：Current opinion in neurobiology

authors： Wong WT,Wong RO

更新日期：2000-02-01 00:00:00

abstract：:Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic st...

journal_title：Current opinion in neurobiology

authors： Blanquie O,Bradke F

更新日期：2018-08-01 00:00:00

abstract：:During the past years, major advances have been made in understanding the sequential events involved in neural plate patterning. Positional information is already conferred to cells of the neural plate at the time of its induction in the ectoderm. The interplay between the BMP- and the Fgf- signaling pathways leads to...

journal_title：Current opinion in neurobiology

authors： Rhinn M,Picker A,Brand M

更新日期：2006-02-01 00:00:00

abstract：:Recent experiments on the retina have examined the effectiveness of various factors (e.g. growth factors, neurotrophins and cytokines) for enhancing survival and reducing injury of retinal neurons, such as photoreceptors and ganglion cells, whose death leads to blindness in degenerative retinal diseases. It has also b...

journal_title：Current opinion in neurobiology

authors： Steinberg RH

更新日期：1994-08-01 00:00:00

abstract：:The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...

journal_title：Current opinion in neurobiology

authors： Zhong W,Chia W

更新日期：2008-02-01 00:00:00

abstract：:The glial regulation of synaptic function provides important modulation of the synaptic and behavioral changes induced by drugs of abuse. In some cases, this regulation is adaptive, reducing drug-induced change, and in other cases maladaptive, contributing to the induction or maintenance of these changes. Understandin...

journal_title：Current opinion in neurobiology

authors： Stellwagen D,Kemp GM,Valade S,Chambon J

更新日期：2019-08-01 00:00:00

abstract：:Rats sweep their vibrissae through space to locate objects in their immediate environment. In essence, their view of the proximal world is generated through pliable hairs that tap and palpate objects. The texture and shape of those objects must be discerned for the rat to assess the value of the object. Furthermore, t...

journal_title：Current opinion in neurobiology

authors： Kleinfeld D,Ahissar E,Diamond ME

更新日期：2006-08-01 00:00:00

abstract：:Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...

journal_title：Current opinion in neurobiology

authors： Wilsch-Bräuninger M,Florio M,Huttner WB

更新日期：2016-08-01 00:00:00

abstract：:Prions cause transmissible and genetic neurodegenerative diseases. Infectious prion particles are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrPSc), which is encoded by a chromosomal gene. Although the PrP gene is single copy, transgenic mice with both alleles of the PrP gene ablat...

journal_title：Current opinion in neurobiology

authors： Prusiner SB

更新日期：1992-10-01 00:00:00

abstract：:Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelect...

journal_title：Current opinion in neurobiology

authors： Scaini D,Ballerini L

更新日期：2018-06-01 00:00:00

abstract：:Ample evidence suggests that upon their retrieval, items in long-term memory enter a transient special state, in which they might become prone to change. The process that generates this state is dubbed 'reconsolidation'. The dominant conceptual framework in this revitalized field of memory research focuses on whether ...

journal_title：Current opinion in neurobiology

authors： Dudai Y

更新日期：2006-04-01 00:00:00

abstract：:Tympanic hearing is a true evolutionary novelty that arose in parallel within early tetrapods. We propose that in these tetrapods, selection for sound localization in air acted upon pre-existing directionally sensitive brainstem circuits, similar to those in fishes. Auditory circuits in birds and lizards resemble this...

journal_title：Current opinion in neurobiology

authors： Carr CE,Christensen-Dalsgaard J

更新日期：2016-10-01 00:00:00