Glial regulation of synaptic function in models of addiction.

abstract：:Neurons have a multiplicity of ionic conductance mechanisms, the interactions of which determine in part the response of a neuron to chemical and electrical synaptic interactions, firing patterns, excitability, membrane potential and action-potential waveform. Several papers published in the past year have provided im...

journal_title：Current opinion in neurobiology

authors： Baxter DA,Byrne JH

更新日期：1991-06-01 00:00:00

abstract：:A fundamental but unsolved problem in neuroscience is how connections between neurons might underlie information processing in central circuits. Building wiring diagrams of neural networks may accelerate our understanding of how they compute. But even if we had wiring diagrams, it is critical to know what neurons in a...

journal_title：Current opinion in neurobiology

authors： Lee WC,Reid RC

更新日期：2011-10-01 00:00:00

abstract：:Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

journal_title：Current opinion in neurobiology

authors： Lüningschrör P,Sendtner M

更新日期：2018-08-01 00:00:00

abstract：:Birds commonly use sound for communication between the sexes. In many songbird species, only males sing and there are pronounced sex differences in the neural song control circuits. By contrast, the auditory circuitry is largely similar in males and females. Both sexes learn to recognize vocalizations heard as juvenil...

journal_title：Current opinion in neurobiology

authors： Brenowitz EA,Remage-Healey L

更新日期：2016-06-01 00:00:00

abstract：:Opiate drugs such as morphine and heroin are among the most effective analgesics known. Prolonged or repeated administration of opiates produces adaptive changes in the nervous system that lead to reduced drug potency or efficacy (tolerance), as well as physiological withdrawal symptoms and behavioral manifestations s...

journal_title：Current opinion in neurobiology

authors： von Zastrow M,Svingos A,Haberstock-Debic H,Evans C

更新日期：2003-06-01 00:00:00

abstract：:Genetic mosaic techniques provide a powerful tool for dissecting gene function in the intricate genetic networks that underlie the formation and function of nervous systems. For instance, it is possible to make individual cells or groups of cells homozygous for mutations of interest at specific points during an organi...

journal_title：Current opinion in neurobiology

authors： Zugates CT,Lee T

更新日期：2004-10-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:Tympanic hearing is a true evolutionary novelty that arose in parallel within early tetrapods. We propose that in these tetrapods, selection for sound localization in air acted upon pre-existing directionally sensitive brainstem circuits, similar to those in fishes. Auditory circuits in birds and lizards resemble this...

journal_title：Current opinion in neurobiology

authors： Carr CE,Christensen-Dalsgaard J

更新日期：2016-10-01 00:00:00

abstract：:The use of gene transfer techniques to express novel proteins within different cellular populations has provided insights into the function and plasticity of the brain. Recently, this technique has been successfully used to explore physiological processes within the CNS and to intervene in neurodegenerative disease an...

journal_title：Current opinion in neurobiology

authors： Fisher LJ,Ray J

更新日期：1994-10-01 00:00:00

abstract：:Neural oscillations are ubiquitous in olfactory systems of mammals, insects and molluscs. Neurophysiological and computational investigations point to common mechanisms for gamma or odor associated oscillations across phyla (40-100Hz in mammals, 20-30Hz in insects, 0.5-1.5Hz in molluscs), engaging the reciprocal dendr...

journal_title：Current opinion in neurobiology

authors： Kay LM

更新日期：2015-04-01 00:00:00

abstract：:Many constituents of Wnt signaling pathways are expressed in the developing and mature nervous systems. Recent work has shown that Wnt signaling controls initial formation of the neural plate and many subsequent patterning decisions in the embryonic nervous system, including formation of the neural crest. Wnt signalin...

journal_title：Current opinion in neurobiology

authors： Patapoutian A,Reichardt LF

更新日期：2000-06-01 00:00:00

abstract：:Studies of the function of the basal forebrain have focused on cholinergic neurons that project to cortical and limbic structures critical for various cognitive abilities. Recent experiments suggest that these neurons serve a modulatory function in cognition, by optimizing cortical information processing and influenci...

journal_title：Current opinion in neurobiology

authors： Baxter MG,Chiba AA

更新日期：1999-04-01 00:00:00

abstract：:The pinnipeds provide a variety of clues to those interested in the vocal learning capabilities of non-human animals. Observational and experimental studies of seals, sea lions, and walruses reveal elements of vocal development, contextual control, plasticity in expression and learning, and even imitation of complex s...

journal_title：Current opinion in neurobiology

authors： Reichmuth C,Casey C

更新日期：2014-10-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:The decision to urinate is a social behavior that is calculated multiple times a day. Many animals perform urine scent-marking which broadcasts their pheromones to regulate the behavior of others and humans are trained at an early age to urinate only at a socially acceptable time and place. The inability to control wh...

journal_title：Current opinion in neurobiology

authors： Mukhopadhyay S,Stowers L

更新日期：2020-02-01 00:00:00

abstract：:Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over a range of speeds, amplitudes and frequencies (vigor). Recent work has ...

journal_title：Current opinion in neurobiology

authors： Dudman JT,Krakauer JW

更新日期：2016-04-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology. Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses hav...

journal_title：Current opinion in neurobiology

authors： Slack RS,Miller FD

更新日期：1996-10-01 00:00:00

abstract：:In the past year significant advances have been made in our understanding of the role of protein dephosphorylation in the control of neuronal function. Molecular cloning has identified a large number of serine/threonine and tyrosine protein phosphatases in the nervous system. Many of these enzymes are selectively enri...

journal_title：Current opinion in neurobiology

authors： Nairn AC,Shenolikar S

更新日期：1992-06-01 00:00:00

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:Recent studies suggest that endocannabinoids act as retrograde messengers at many synapses in the central nervous system. Activation of phospholipases, either through calcium-mediated or receptor-mediated signaling, leads to the formation and release of endocannabinoids. These lipophilic signaling molecules diffuse to...

journal_title：Current opinion in neurobiology

authors： Kreitzer AC,Regehr WG

更新日期：2002-06-01 00:00:00

abstract：:At least one non-human primate species-the marmoset monkey-exhibits developmental processes similar to human vocal development. These processes include babbling-like early vocal output and a role for social feedback in changing this output into mature-sounding vocalizations. Such parallel behaviors provide a window th...

journal_title：Current opinion in neurobiology

authors： Ghazanfar AA,Zhang YS

更新日期：2016-10-01 00:00:00

abstract：:The vestibular system provides an attractive model for understanding how changes in cellular and synaptic activity influence learning and memory in a quantifiable behavior, the vestibulo-ocular reflex. The vestibulo-ocular reflex produces eye movements that compensate for head motion; simple yet powerful forms of moto...

journal_title：Current opinion in neurobiology

authors： Gittis AH,du Lac S

更新日期：2006-08-01 00:00:00

abstract：:During the past year,several model systems have been developed to identify cellular and biochemical events involved in neuronal cell death, to investigate the role of bcl-2 in cell survival, and to characterize the relationship between cell death and the cell cycle. ...

journal_title：Current opinion in neurobiology

authors： Pittman RN,Mills JC,DiBenedetto AJ,Hynicka WP,Wang S

更新日期：1994-02-01 00:00:00

abstract：:Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cor...

journal_title：Current opinion in neurobiology

authors： Courchesne E

更新日期：1997-04-01 00:00:00

abstract：:Neurotransmitters are released by Ca(2+)-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at a specialised presynaptic plasma membrane region, the active zone, where they are primed to a fusion competent state. The nature of this priming reaction has long been enigmatic. Recent evidence d...

journal_title：Current opinion in neurobiology

authors： Brose N,Rosenmund C,Rettig J

更新日期：2000-06-01 00:00:00

abstract：:Discoveries in modern human neuroscience are increasingly driven by quantitative understanding of complex data. Data-intensive approaches to modeling have promise to dramatically advance our understanding of the brain and critically enable neuroengineering capabilities. In this review, we provide an accessible primer ...

journal_title：Current opinion in neurobiology

authors： Brunton BW,Beyeler M

更新日期：2019-10-01 00:00:00

abstract：:Our understanding of the cellular and molecular bases of transduction of painful stimuli has burgeoned in the past year, mainly as a result of studies on isolated sensory neurones in culture. The ion channels underlying neuronal responses to noxious heat, to protons and to ATP have recently been characterized. The typ...

journal_title：Current opinion in neurobiology

authors： Cesare P,McNaughton P

更新日期：1997-08-01 00:00:00

abstract：:The neuropeptide oxytocin has had key roles throughout mammalian evolution in the regulation of complex social cognition and behaviors, such as attachment, parental care, pair-bonding, as well as social exploration and recognition. Recently, studies have begun to provide evidence that the function of this neuropeptide...

journal_title：Current opinion in neurobiology

authors： Kumsta R,Heinrichs M

更新日期：2013-02-01 00:00:00

abstract：:The investigation of mechanosensory feedback to locomotion has been hindered by the challenge of recording neurons in motion. Genetic accessibility and optical transparency of zebrafish larvae provide means to revisit this question. Glutamatergic Rohon-Beard (RB) and GABAergic CSF-contacting neurons (CSF-cNs) are spin...

journal_title：Current opinion in neurobiology

authors： Knafo S,Wyart C

更新日期：2018-10-01 00:00:00