Peripheral pain mechanisms.

abstract：:In recent years spectacular advances in the field of epigenetics have taken place. Multiple lines of evidence that connect epigenetic regulation to brain functions have been accumulating. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. Control is achieved thro...

journal_title：Current opinion in neurobiology

authors： Zocchi L,Sassone-Corsi P

更新日期：2010-08-01 00:00:00

abstract：:Almost 30 years ago, actin was identified as the major cytoskeletal component of dendritic spines. Since then, its role in the remarkable dynamics of spine morphology have been detailed with live-cell views establishing that spine shape dynamics are an important requirement for synaptogenesis and synaptic plasticity. ...

journal_title：Current opinion in neurobiology

authors： Frost NA,Kerr JM,Lu HE,Blanpied TA

更新日期：2010-10-01 00:00:00

abstract：:Many constituents of Wnt signaling pathways are expressed in the developing and mature nervous systems. Recent work has shown that Wnt signaling controls initial formation of the neural plate and many subsequent patterning decisions in the embryonic nervous system, including formation of the neural crest. Wnt signalin...

journal_title：Current opinion in neurobiology

authors： Patapoutian A,Reichardt LF

更新日期：2000-06-01 00:00:00

abstract：:The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These ...

journal_title：Current opinion in neurobiology

authors： Cenci MA,Lindgren HS

更新日期：2007-12-01 00:00:00

abstract：:Schizophrenia remains a daunting challenge for efforts aimed at identifying fundamental pathophysiological processes and to develop evidence-based effective treatments and interventions. One reason for the lack of progress lies in the fact that the pathophysiology of schizophrenia has been predominantly conceived in t...

journal_title：Current opinion in neurobiology

authors： Uhlhaas PJ

更新日期：2013-04-01 00:00:00

abstract：:Recent results have shown the possibility of both reconstructing connectomes of small but biologically interesting circuits and extracting from these connectomes insights into their function. However, these reconstructions were heroic proof-of-concept experiments, requiring person-months of effort per neuron reconstru...

journal_title：Current opinion in neurobiology

authors： Plaza SM,Scheffer LK,Chklovskii DB

更新日期：2014-04-01 00:00:00

abstract：:Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

journal_title：Current opinion in neurobiology

authors： Lüningschrör P,Sendtner M

更新日期：2018-08-01 00:00:00

abstract：:Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...

journal_title：Current opinion in neurobiology

authors： Sakurai T

更新日期：2013-10-01 00:00:00

abstract：:Work during the past year has revealed increasing diversity and complexity of sensory inputs that trigger behavior, and correspondingly wide-ranging adaptations of sensory receptors and receptor organs. Many of these have been discovered by taking careful account of the animal in its natural habitat. Studies on centra...

journal_title：Current opinion in neurobiology

authors： Camhi JM

更新日期：1993-12-01 00:00:00

abstract：:The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...

journal_title：Current opinion in neurobiology

authors： Zhong W,Chia W

更新日期：2008-02-01 00:00:00

abstract：:A diverse group of biochemically distinct proteins give rise to amyloids, each of which is associated with a different disease. These amyloid proteins share numerous properties and typically arise from the abnormal processing of an amyloid precursor protein. The classification, mechanisms and biochemistry of amyloid f...

journal_title：Current opinion in neurobiology

authors： Castaño EM,Wisniewski T,Frangione B

更新日期：1991-10-01 00:00:00

abstract：:Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over a range of speeds, amplitudes and frequencies (vigor). Recent work has ...

journal_title：Current opinion in neurobiology

authors： Dudman JT,Krakauer JW

更新日期：2016-04-01 00:00:00

abstract：:Reinforcement learning provides both qualitative and quantitative frameworks for understanding and modeling adaptive decision-making in the face of rewards and punishments. Here we review the latest dispatches from the forefront of this field, and map out some of the territories where lie monsters. ...

journal_title：Current opinion in neurobiology

authors： Dayan P,Niv Y

更新日期：2008-04-01 00:00:00

abstract：:Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for...

journal_title：Current opinion in neurobiology

authors： Herstel LJ,Wierenga CJ

更新日期：2020-08-24 00:00:00

abstract：:Recent studies have shown that frontoparietal cortices and interconnecting regions in the basal ganglia and the cerebellum are related to motor skill learning. We propose that motor skill learning occurs independently and in different coordinates in two sets of loop circuits: cortex-basal ganglia and cortex-cerebellum...

journal_title：Current opinion in neurobiology

authors： Hikosaka O,Nakamura K,Sakai K,Nakahara H

更新日期：2002-04-01 00:00:00

abstract：:Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent ...

journal_title：Current opinion in neurobiology

authors： Gusella JF,MacDonald ME

更新日期：1998-06-01 00:00:00

abstract：:Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper und...

journal_title：Current opinion in neurobiology

authors： Temple S,Alvarez-Buylla A

更新日期：1999-02-01 00:00:00

abstract：:Recent advances in multi-electrode recording have brought us closer to understanding how visual information is encoded by populations of retinal ganglion cells. By monitoring the visual responses of many ganglion cells at once, it is now possible to examine how ganglion cells act together to encode a visual scene. ...

journal_title：Current opinion in neurobiology

authors： Nirenberg S,Latham PE

更新日期：1998-08-01 00:00:00

abstract：:Recent experiments on the retina have examined the effectiveness of various factors (e.g. growth factors, neurotrophins and cytokines) for enhancing survival and reducing injury of retinal neurons, such as photoreceptors and ganglion cells, whose death leads to blindness in degenerative retinal diseases. It has also b...

journal_title：Current opinion in neurobiology

authors： Steinberg RH

更新日期：1994-08-01 00:00:00

abstract：:The recent invention of super-resolution fluorescence microscopy brings more than an order of magnitude gain in the spatial resolution of light microscopy. New opportunities keep emerging with the multicolor, three-dimensional, and live imaging functionalities gained in the past three years. The power of this technolo...

journal_title：Current opinion in neurobiology

authors： Dani A,Huang B

更新日期：2010-10-01 00:00:00

abstract：:In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of f...

journal_title：Current opinion in neurobiology

authors： Villemagne VL,Okamura N

更新日期：2016-02-01 00:00:00

abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

journal_title：Current opinion in neurobiology

authors： Griffith LC

更新日期：2012-08-01 00:00:00

abstract：:Ambiguous figures that may take on the appearance of two or more distinct forms have fascinated philosophers and psychologists for generations. Recently, several laboratories have studied the neuronal basis of perceptual appearance at the level of single neurons in the cerebral cortex. Experiments that integrate neuro...

journal_title：Current opinion in neurobiology

authors： Parker AJ,Krug K

更新日期：2003-08-01 00:00:00

abstract：:Cell-cell communication directs the development of photoreceptor cells in the Drosophila retina. A recent set of studies has provided a genetic dissection of one of these interactions, the induction of the R7 photoreceptor cell by the neighboring R8 photoreceptor cell. The results from these experiments shape our unde...

journal_title：Current opinion in neurobiology

authors： Krämer H,Cagan RL

更新日期：1994-02-01 00:00:00

abstract：:During the past year,several model systems have been developed to identify cellular and biochemical events involved in neuronal cell death, to investigate the role of bcl-2 in cell survival, and to characterize the relationship between cell death and the cell cycle. ...

journal_title：Current opinion in neurobiology

authors： Pittman RN,Mills JC,DiBenedetto AJ,Hynicka WP,Wang S

更新日期：1994-02-01 00:00:00

abstract：:Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals t...

journal_title：Current opinion in neurobiology

authors： Llorens-Bobadilla E,Martin-Villalba A

更新日期：2017-02-01 00:00:00

abstract：:The rapid accumulation of neuroproteomics data in recent years has prompted the emergence of novel antibody-based imaging methods that aim to understand the anatomical and functional context of the multitude of identified proteins. The pioneering field of ultrastructural multiplexed proteomic imaging now includes a nu...

journal_title：Current opinion in neurobiology

authors： Micheva KD,Bruchez MP

更新日期：2012-02-01 00:00:00

abstract：:Recent developments have led to a greater insight into the complex processes of perception of visual motion. A better understanding of the neuronal circuitry involved and advances in electrophysiological techniques have allowed researchers to alter the perception of an animal with a stimulating electrode. In addition,...

journal_title：Current opinion in neurobiology

authors： Snowden RJ

更新日期：1992-04-01 00:00:00

abstract：:Despite their differences, human language and the vocal communication of nonhuman primates share many features. Both constitute a form of joint action, rely on similar neural mechanisms, and involve discrete, combinatorial cognition. These shared features suggest that during evolution the ancestors of modern primates ...

journal_title：Current opinion in neurobiology

authors： Seyfarth RM,Cheney DL

更新日期：2014-10-01 00:00:00

abstract：:Extracting the structure of complex environments is at the core of our ability to interpret the present and predict the future. This skill is important for a range of behaviours from navigating a new city to learning music and language. Classical approaches that investigate our ability to extract the principles of org...

journal_title：Current opinion in neurobiology

authors： Kourtzi Z,Welchman AE

更新日期：2019-10-01 00:00:00