Abstract:
:The recent invention of super-resolution fluorescence microscopy brings more than an order of magnitude gain in the spatial resolution of light microscopy. New opportunities keep emerging with the multicolor, three-dimensional, and live imaging functionalities gained in the past three years. The power of this technology has been demonstrated by imaging the organization of organelles and molecular complexes, with recent applications increasingly showing its potential in neurobiology. These developments are exemplified by the visualization of components inside dendritic spines to fine morphologies of neurons. In combination with correlative electron microscopy, functional imaging, and electrical/optogenetic stimulation tools, super-resolution fluorescence microscopy has the potential to provide further insights ranging from the molecular details of neurons up to the functional mechanisms of neuronal circuits.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Dani A,Huang Bdoi
10.1016/j.conb.2010.07.006subject
Has Abstractpub_date
2010-10-01 00:00:00pages
648-52issue
5eissn
0959-4388issn
1873-6882pii
S0959-4388(10)00114-5journal_volume
20pub_type
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journal_title:Current opinion in neurobiology
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