Towards new approaches to disorders of fear and anxiety.

abstract：:Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spe...

journal_title：Current opinion in neurobiology

authors： Egnor SR,Seagraves KM

更新日期：2016-06-01 00:00:00

abstract：:The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...

journal_title：Current opinion in neurobiology

authors： Linster C,Cleland TA

更新日期：2016-10-01 00:00:00

abstract：:Sex steroid hormones exert a profound influence on the sexual differentiation and function of the neural circuits that mediate dimorphic behaviors. Both estrogen and testosterone are essential for male typical behaviors in many species. Recent studies with genetically modified mice provide important new insights into ...

journal_title：Current opinion in neurobiology

authors： Wu MV,Shah NM

更新日期：2011-02-01 00:00:00

abstract：:Action potential conduction in myelinated nerve fibers depends on a polarized axonal membrane. Voltage-gated Na(+) and K(+) channels are clustered at nodes of Ranvier and mediate the transmembrane currents necessary for rapid saltatory conduction. Paranodal junctions flank nodes and function as attachment sites for my...

journal_title：Current opinion in neurobiology

authors： Schafer DP,Rasband MN

更新日期：2006-10-01 00:00:00

abstract：:Our understanding of the cellular and molecular bases of transduction of painful stimuli has burgeoned in the past year, mainly as a result of studies on isolated sensory neurones in culture. The ion channels underlying neuronal responses to noxious heat, to protons and to ATP have recently been characterized. The typ...

journal_title：Current opinion in neurobiology

authors： Cesare P,McNaughton P

更新日期：1997-08-01 00:00:00

abstract：:The use of gene transfer techniques to express novel proteins within different cellular populations has provided insights into the function and plasticity of the brain. Recently, this technique has been successfully used to explore physiological processes within the CNS and to intervene in neurodegenerative disease an...

journal_title：Current opinion in neurobiology

authors： Fisher LJ,Ray J

更新日期：1994-10-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:Neuroepithelial cells, the progenitors to the CNS neurons and glia, undergo both symmetric and asymmetric divisions. Symmetric divisions underlie the proliferation of neuroepithelial cells that predominates early in CNS development. Asymmetric divisions are thought to generate the cell types derived from neuroepitheli...

journal_title：Current opinion in neurobiology

authors： Huttner WB,Brand M

更新日期：1997-02-01 00:00:00

abstract：:It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central ner...

journal_title：Current opinion in neurobiology

authors： Boulanger LM,Huh GS,Shatz CJ

更新日期：2001-10-01 00:00:00

abstract：:Stimulus-driven gene expression is a ubiquitous feature of biological systems, allowing cells and organisms to adapt their function in a stimulus-driven manner. Neurons exhibit complex and heterogeneous activity-dependent gene expression, but many of the canonical mechanisms that transduce electrical activity into gen...

journal_title：Current opinion in neurobiology

authors： Heinz DA,Bloodgood BL

更新日期：2020-08-01 00:00:00

abstract：:In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of f...

journal_title：Current opinion in neurobiology

authors： Villemagne VL,Okamura N

更新日期：2016-02-01 00:00:00

abstract：:In the mammalian cortex, the classic view assumes that the output information of a neuron is encoded in rather stereotyped action potentials, which provide an all-or-none or digital way of communication between cell body and axonal boutons. A role for subthreshold signal propagation within cortical axons has largely b...

journal_title：Current opinion in neurobiology

authors： Alle H,Geiger JR

更新日期：2008-06-01 00:00:00

abstract：:Biological systems use internal circadian clocks to efficiently organize physiological and behavioral activity within the 24-hour time domain. In the absence of time cues, circadian periods vary slightly from 24 hours, but in nature, ambient light serves as the most salient synchronizer for these rhythms, fine-tuning ...

journal_title：Current opinion in neurobiology

authors： Davidson AJ,Menaker M

更新日期：2003-12-01 00:00:00

abstract：:The study of spatial maps of the ventral sensory-motor cortex (vSMC) dates back to the earliest cortical stimulation studies. This review surveys a number of recent and historical reports of the features and function of spatial maps within vSMC towards the human behavior of speaking. Representations of the vocal tract...

journal_title：Current opinion in neurobiology

authors： Conant D,Bouchard KE,Chang EF

更新日期：2014-02-01 00:00:00

abstract：:Although the presence of neuromodulators in mammalian sensory systems has been noted for some time, a groundswell of evidence has now begun to document the scope of these regulatory mechanisms in several sensory systems, highlighting the importance of neuromodulation in shaping feature extraction at all levels of neur...

journal_title：Current opinion in neurobiology

authors： Hurley LM,Devilbiss DM,Waterhouse BD

更新日期：2004-08-01 00:00:00

abstract：:For many years, it has been postulated that interactions between motor commands and somatic perception in the sensorimotor cortices exist, but they have been difficult to demonstrate. Recent studies have made demonstration of this interaction easier and suggest that cortical activity related to somatic sensation and p...

journal_title：Current opinion in neurobiology

authors： Nelson RJ

更新日期：1996-12-01 00:00:00

abstract：:The issue of whether encoding of geometric information for navigational purposes crucially depends on environmental experience or whether it is innately predisposed in the brain has been recently addressed in controlled rearing studies. Non-human animals can make use of the geometric shape of an environment for spatia...

journal_title：Current opinion in neurobiology

authors： Vallortigara G,Sovrano VA,Chiandetti C

更新日期：2009-02-01 00:00:00

abstract：:In bilaterally symmetric organisms, the midline is a critical organizing center for the developing central nervous system. There is a striking conservation of the molecules and mechanisms that control axon path finding at the midline in vertebrate and invertebrate nervous systems. The majority of axons in the CNS cros...

journal_title：Current opinion in neurobiology

authors： Evans TA,Bashaw GJ

更新日期：2010-02-01 00:00:00

abstract：:Enduring social bonds play an essential role in human society. These bonds positively affect psychological, physiological, and behavioral functions. Here, we review the recent literature on the neurobiology, particularly the role of oxytocin and dopamine, of pair bond formation, bond disruption, and social buffering e...

journal_title：Current opinion in neurobiology

authors： Lieberwirth C,Wang Z

更新日期：2016-10-01 00:00:00

abstract：:Slow waves, the hallmark of NREM (Non Rapid Eye Movement) sleep, are not uniformly distributed across the cortical surface, but can occur locally and asynchronously across brain regions. Their regional distribution and amplitude is affected by brain maturation and by time spent awake, mediated in part by experience-de...

journal_title：Current opinion in neurobiology

authors： Siclari F,Tononi G

更新日期：2017-06-01 00:00:00

abstract：:Neurotransmitters are released by Ca(2+)-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at a specialised presynaptic plasma membrane region, the active zone, where they are primed to a fusion competent state. The nature of this priming reaction has long been enigmatic. Recent evidence d...

journal_title：Current opinion in neurobiology

authors： Brose N,Rosenmund C,Rettig J

更新日期：2000-06-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:Recent studies have provided a significant advance in our understanding of motor axon pathfinding. In particular, sources of guidance cues and some of the mechanisms used by motor growth cones during pathfinding have been identified. ...

journal_title：Current opinion in neurobiology

authors： Westerfield M

更新日期：1992-02-01 00:00:00

abstract：:Neural oscillations are ubiquitous in olfactory systems of mammals, insects and molluscs. Neurophysiological and computational investigations point to common mechanisms for gamma or odor associated oscillations across phyla (40-100Hz in mammals, 20-30Hz in insects, 0.5-1.5Hz in molluscs), engaging the reciprocal dendr...

journal_title：Current opinion in neurobiology

authors： Kay LM

更新日期：2015-04-01 00:00:00

abstract：:A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...

journal_title：Current opinion in neurobiology

authors： Carney LH

更新日期：1999-08-01 00:00:00

abstract：:The polarity of neurotransmission mediated by the gamma-amino butyric acid (GABA) type A receptor depends crucially on intracellular chloride concentration, which is largely determined by the expression and function of cation/chloride co-transporters. Recent evidence shows how both activity and neurotrophic factors ca...

journal_title：Current opinion in neurobiology

authors： Fiumelli H,Woodin MA

更新日期：2007-02-01 00:00:00

abstract：:The insular cortex is the primary cortical site devoted to taste processing. A large body of evidence is available for how insular neurons respond to gustatory stimulation in both anesthetized and behaving animals. Most of the reports describe broadly tuned neurons that are involved in processing the chemosensory, phy...

journal_title：Current opinion in neurobiology

authors： Maffei A,Haley M,Fontanini A

更新日期：2012-08-01 00:00:00

abstract：:Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent ...

journal_title：Current opinion in neurobiology

authors： Gusella JF,MacDonald ME

更新日期：1998-06-01 00:00:00

abstract：:The gene product responsible for autosomal recessive juvenile Parkinsonism, Parkin, has been observed to have ubiquitin ligase activity. This finding has changed the direction of studies on Parkinson's disease by suggesting that abnormal protein turnover might be involved in its pathogenesis. A number of potentially n...

journal_title：Current opinion in neurobiology

authors： Imai Y,Takahashi R

更新日期：2004-06-01 00:00:00

abstract：:Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differe...

journal_title：Current opinion in neurobiology

authors： Temple S,Qian X

更新日期：1996-02-01 00:00:00