Abstract:
:Stimulus-driven gene expression is a ubiquitous feature of biological systems, allowing cells and organisms to adapt their function in a stimulus-driven manner. Neurons exhibit complex and heterogeneous activity-dependent gene expression, but many of the canonical mechanisms that transduce electrical activity into gene regulation are promiscuous and convergent. We discuss literature that describes mechanisms that drive activity-dependent gene expression with a focus on those that allow the nucleus to decode complex stimulus-features into appropriate transcriptional programs.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Heinz DA,Bloodgood BLdoi
10.1016/j.conb.2020.03.002subject
Has Abstractpub_date
2020-08-01 00:00:00pages
131-136eissn
0959-4388issn
1873-6882pii
S0959-4388(20)30053-2journal_volume
63pub_type
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