Abstract:
:Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression. microRNAs (miRNAs) have emerged as essential regulators of gene expression. They are small non-coding RNAs that regulate mRNA stability and translation by interacting with the 3' untranslated region (3' UTR) of mRNAs. miRNAs are located to neuronal processes to regulate protein synthesis locally and their expression is regulated by synaptic activity. This article reviews recent findings on the role of miRNAs in synapse development and synaptic plasticity.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Hu Z,Li Zdoi
10.1016/j.conb.2017.02.014subject
Has Abstractpub_date
2017-08-01 00:00:00pages
24-31eissn
0959-4388issn
1873-6882pii
S0959-4388(16)30180-5journal_volume
45pub_type
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