Nanomaterials at the neural interface.

abstract：:The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...

journal_title：Current opinion in neurobiology

authors： Backman S,Stambolic V,Mak T

更新日期：2002-10-01 00:00:00

abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...

journal_title：Current opinion in neurobiology

authors： Rawson RL,Martin EA,Williams ME

更新日期：2017-08-01 00:00:00

abstract：:Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for...

journal_title：Current opinion in neurobiology

authors： Herstel LJ,Wierenga CJ

更新日期：2020-08-24 00:00:00

abstract：:Iterated learning describes the process whereby an individual learns their behaviour by exposure to another individual's behaviour, who themselves learnt it in the same way. It can be seen as a key mechanism of cultural evolution. We review various methods for understanding how behaviour is shaped by the iterated lear...

journal_title：Current opinion in neurobiology

authors： Kirby S,Griffiths T,Smith K

更新日期：2014-10-01 00:00:00

abstract：:The ionotropic GABA receptor (GABAAR) mediates fast inhibition in the brain. The GABAAR pore-forming (α, β, and non-α/β) subunits were isolated approximately 30 years ago and have since been the focus of extensive studies. As a result, many properties of GABAARs, including subunit assembly and channel and pharmacologi...

journal_title：Current opinion in neurobiology

authors： Tomita S

更新日期：2019-08-01 00:00:00

abstract：:During the past years, major advances have been made in understanding the sequential events involved in neural plate patterning. Positional information is already conferred to cells of the neural plate at the time of its induction in the ectoderm. The interplay between the BMP- and the Fgf- signaling pathways leads to...

journal_title：Current opinion in neurobiology

authors： Rhinn M,Picker A,Brand M

更新日期：2006-02-01 00:00:00

abstract：:Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and prote...

journal_title：Current opinion in neurobiology

authors： Nestler EJ

更新日期：1997-10-01 00:00:00

abstract：:Synapses are specialized sites of cell contact that mediate information flow between neurons and their targets. Genetic screens in the nematode C. elegans have led to the discovery of a number of molecules required for synapse patterning and assembly. Recent studies have demonstrated the importance of guidepost cells ...

journal_title：Current opinion in neurobiology

authors： Margeta MA,Shen K,Grill B

更新日期：2008-02-01 00:00:00

abstract：:The Drosophila visual system offers an excellent opportunity for studying the development of proper retinotopic connections at the level of individual identifiable cell types. Recent work suggests that, despite obvious anatomical and developmental differences, at least some of the general developmental strategies oper...

journal_title：Current opinion in neurobiology

authors： Kunes S,Steller H

更新日期：1993-02-01 00:00:00

abstract：:Slow waves, the hallmark of NREM (Non Rapid Eye Movement) sleep, are not uniformly distributed across the cortical surface, but can occur locally and asynchronously across brain regions. Their regional distribution and amplitude is affected by brain maturation and by time spent awake, mediated in part by experience-de...

journal_title：Current opinion in neurobiology

authors： Siclari F,Tononi G

更新日期：2017-06-01 00:00:00

abstract：:This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in...

journal_title：Current opinion in neurobiology

authors： Adler R

更新日期：1993-10-01 00:00:00

abstract：:Quantal neurotransmitter release at nerve terminals is tightly regulated by the presynaptic Ca2+ concentration. Here, we summarise current advances in understanding how the interplay between presynaptic Ca2+ dynamics and different Ca2+ release sensors shapes action potential-evoked release on a timescale from hundreds...

journal_title：Current opinion in neurobiology

authors： Volynski KE,Krishnakumar SS

更新日期：2018-08-01 00:00:00

abstract：:The aging peripheral nervous system (PNS) is prone to a number of disorders, including the development of neuropathies and increased regenerative failure. Although the basic mechanisms of the aging PNS are still rather murky, recent work has revealed that 'old' Schwann cells acquire a number of dysfunctions in mammals...

journal_title：Current opinion in neurobiology

authors： Painter MW

更新日期：2017-12-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found i...

journal_title：Current opinion in neurobiology

authors： Augustine GJ

更新日期：2001-06-01 00:00:00

abstract：:The pinnipeds provide a variety of clues to those interested in the vocal learning capabilities of non-human animals. Observational and experimental studies of seals, sea lions, and walruses reveal elements of vocal development, contextual control, plasticity in expression and learning, and even imitation of complex s...

journal_title：Current opinion in neurobiology

authors： Reichmuth C,Casey C

更新日期：2014-10-01 00:00:00

abstract：:Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super...

journal_title：Current opinion in neurobiology

authors： Dent EW,Merriam EB,Hu X

更新日期：2011-02-01 00:00:00

abstract：:Reinforcement learning provides both qualitative and quantitative frameworks for understanding and modeling adaptive decision-making in the face of rewards and punishments. Here we review the latest dispatches from the forefront of this field, and map out some of the territories where lie monsters. ...

journal_title：Current opinion in neurobiology

authors： Dayan P,Niv Y

更新日期：2008-04-01 00:00:00

abstract：:Classical conditioning, the simplest form of associative learning, is one of the most studied paradigms in behavioural psychology. Since the formal description of classical conditioning by Pavlov, lesion studies in animals have identified a number of anatomical structures involved in, and necessary for, classical cond...

journal_title：Current opinion in neurobiology

authors： Büchel C,Dolan RJ

更新日期：2000-04-01 00:00:00

abstract：:We discuss very recent experiments with rodents addressing the idea that long-term memories initially depending on the hippocampus, over a prolonged period, become independent of it. No unambiguous recent evidence exists to substantiate that this occurs. Most experiments find that recent and remote memories are equall...

journal_title：Current opinion in neurobiology

authors： Sutherland RJ,Lehmann H

更新日期：2011-06-01 00:00:00

abstract：:The analysis of complex human diseases has been spurred by the number of published genomic sequence variants - many identified in the course of sequencing the human genome. But, to be useful for genetic analysis, variants have to be mapped accurately, their frequencies in various populations determined, and automated ...

journal_title：Current opinion in neurobiology

authors： Nowotny P,Kwon JM,Goate AM

更新日期：2001-10-01 00:00:00

abstract：:This review focuses on the neurobiological processes involved in achieving successful abstinence from drugs of abuse. While there is clinical and public health value in knowing if the deficits associated with drug use correct with abstinence, studying the neurobiology that underlies successful abstinence can also illu...

journal_title：Current opinion in neurobiology

authors： Garavan H,Brennan KL,Hester R,Whelan R

更新日期：2013-08-01 00:00:00

abstract：:Our understanding of the central nervous system (CNS) development has been strongly enhanced by the recent progress of single-cell multiomics approaches. Certainly, the multiplex profiling of individual cell epigenomes and transcriptomes together with dynamic lineage tracing systems brings encouraging new perspectives...

journal_title：Current opinion in neurobiology

authors： Solanelles-Farré L,Telley L

更新日期：2020-11-07 00:00:00

abstract：:The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our under...

journal_title：Current opinion in neurobiology

authors： Benakis C,Martin-Gallausiaux C,Trezzi JP,Melton P,Liesz A,Wilmes P

更新日期：2020-04-01 00:00:00

abstract：:The idea that visual signals relayed by the parvocellular and magnocellular subdivisions of the lateral geniculate nucleus remain segregated in the cerebral cortex has attracted considerable attention. It has been proposed that parvocellular contributions dominate in the temporal visual cortex, and that magnocellular ...

journal_title：Current opinion in neurobiology

authors： Maunsell JH

更新日期：1992-08-01 00:00:00

abstract：:Sexual communication can evolve in response to sexual selection, and it can also cause behavioral reproductive isolation between populations and thus drive speciation. Anurans are an excellent system to investigate these links between behavior and evolution because we have detailed knowledge of how neural mechanisms g...

journal_title：Current opinion in neurobiology

authors： Ryan MJ,Guerra MA

更新日期：2014-10-01 00:00:00

abstract：:Sensory gating mechanisms are deployed during vertebrate locomotion to ensure that adaptive and appropriate motor responses to afferent input occur during all phases of the movement cycle. Recent animal studies on the integration of cutaneous information have investigated the roles of interneurones in sensory gating. ...

journal_title：Current opinion in neurobiology

authors： Sillar KT

更新日期：1991-12-01 00:00:00

abstract：:Priming is a nonconscious form of memory in which an encounter with a stimulus influences the subsequent identification, production or classification of the same or a related stimulus. Neuroimaging studies have revealed that behavioral priming is typically accompanied by reduced activity in several cortical regions. W...

journal_title：Current opinion in neurobiology

authors： Schacter DL,Wig GS,Stevens WD

更新日期：2007-04-01 00:00:00

abstract：:Vision research has traditionally been studied in stationary subjects observing stimuli, and rarely during navigation. Recent research using virtual reality environments for mice has revealed that responses even in the primary visual cortex are modulated by spatial context - identical scenes presented in different pos...

journal_title：Current opinion in neurobiology

authors： Saleem AB

更新日期：2020-10-01 00:00:00

abstract：:Sensory perception in the real world requires proper integration of different modality inputs. Process of multisensory integration is not uniform. It varies from individual to individual and changes at different behavioral states of the animal. What factors affect multisensory integration? How does the mammalian brain...

journal_title：Current opinion in neurobiology

authors： Choi I,Lee JY,Lee SH

更新日期：2018-10-01 00:00:00