Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation.

abstract：:Over the past decade, developmental neuroscience has been transformed by the widespread application of confocal and two-photon fluorescence microscopy. Even greater progress is imminent, as recent innovations in microscopy now enable imaging with increased depth, speed, and spatial resolution; reduced phototoxicity; a...

journal_title：Current opinion in neurobiology

authors： Wu Y,Christensen R,Colón-Ramos D,Shroff H

更新日期：2013-12-01 00:00:00

abstract：:Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of th...

journal_title：Current opinion in neurobiology

authors： Yin JC,Tully T

更新日期：1996-04-01 00:00:00

abstract：:For many years, it has been postulated that interactions between motor commands and somatic perception in the sensorimotor cortices exist, but they have been difficult to demonstrate. Recent studies have made demonstration of this interaction easier and suggest that cortical activity related to somatic sensation and p...

journal_title：Current opinion in neurobiology

authors： Nelson RJ

更新日期：1996-12-01 00:00:00

abstract：:The glial regulation of synaptic function provides important modulation of the synaptic and behavioral changes induced by drugs of abuse. In some cases, this regulation is adaptive, reducing drug-induced change, and in other cases maladaptive, contributing to the induction or maintenance of these changes. Understandin...

journal_title：Current opinion in neurobiology

authors： Stellwagen D,Kemp GM,Valade S,Chambon J

更新日期：2019-08-01 00:00:00

abstract：:Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...

journal_title：Current opinion in neurobiology

authors： McGehee DS,Role LW

更新日期：1996-06-01 00:00:00

abstract：:Müller Glia (MG), the radial glia cells of the retina, have spectacular morphologies subserving their enormous functional complexity. As early as 1892, the great neuroanatomist Santiago Ramon y Cajal studied the morphological development of MG, defining several steps in their morphogenesis [1,2]. However, the molecula...

journal_title：Current opinion in neurobiology

authors： MacDonald RB,Charlton-Perkins M,Harris WA

更新日期：2017-12-01 00:00:00

abstract：:Accurate neural crest cell (NCC) migration requires tight control of cell adhesions, cytoskeletal dynamics and cell motility. Cadherins and RhoGTPases are critical molecular players that regulate adhesions and motility during initial delamination of NCCs from the neuroepithelium. Recent studies have revealed multiple ...

journal_title：Current opinion in neurobiology

authors： Clay MR,Halloran MC

更新日期：2011-02-01 00:00:00

abstract：:AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the...

journal_title：Current opinion in neurobiology

authors： Anggono V,Huganir RL

更新日期：2012-06-01 00:00:00

abstract：:Previously, eye positions were characterized by the direction of sight, which has two degrees of freedom for conjugate movements and three degrees of freedom for vergent movements. Several groups have recently presented reliable data and unconventional models on binocular coordination, where all three degrees of freed...

journal_title：Current opinion in neurobiology

authors： Hepp K

更新日期：1994-12-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:Thermal information about skin surface temperature is a key sense for the perception of object identity and valence. The identification of ion channels involved in the transduction of thermal changes has provided a genetic access point to the thermal system. However, from sensory specific 'labeled-lines' to multimodal...

journal_title：Current opinion in neurobiology

authors： Bokiniec P,Zampieri N,Lewin GR,Poulet JF

更新日期：2018-10-01 00:00:00

abstract：:The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...

journal_title：Current opinion in neurobiology

authors： Sharpee TO,Calhoun AJ,Chalasani SH

更新日期：2014-04-01 00:00:00

abstract：:This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in...

journal_title：Current opinion in neurobiology

authors： Adler R

更新日期：1993-10-01 00:00:00

abstract：:Recent work on the retinotectal projection clearly establishes the roles of neuronal activity and position-based cues in the patterning of nerve connections. In some species, the high degree of spatial order has been shown to emerge from a continued process of terminal growth and refinement. The future challenge is no...

journal_title：Current opinion in neurobiology

authors： Fraser SE

更新日期：1992-02-01 00:00:00

abstract：:Reverse genetic techniques, including gene 'knockouts' and transgenesis, allow defined mutations to be introduced into the mouse genome. The application of these techniques to neurobiology is beginning to provide a bridge between genes and cognition. Specifically, genetically altered mice make it possible to explore m...

journal_title：Current opinion in neurobiology

authors： Mayford M,Abel T,Kandel ER

更新日期：1995-04-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cor...

journal_title：Current opinion in neurobiology

authors： Courchesne E

更新日期：1997-04-01 00:00:00

abstract：:Research on spatial problem-solving over the past two years has linked the hippocampus to path integration, that is, the use of movement-related cues to guide spatial behavior. Path integration may underlie the forms of place learning that are impaired by hippocampal damage. It remains a challenge to determine whether...

journal_title：Current opinion in neurobiology

authors： Whishaw IQ,McKenna JE,Maaswinkel H

更新日期：1997-04-01 00:00:00

abstract：:Standard economic theories conceive homo economicus as a rational decision maker capable of maximizing utility. In reality, however, people tend to approximate optimal decision-making strategies through a collection of heuristic routines. Some of these routines are driven by emotional processes, and others are adjuste...

journal_title：Current opinion in neurobiology

authors： Lee D

更新日期：2006-04-01 00:00:00

abstract：:Motor behaviors result from information processing that occurs in multiple neural networks acting at all levels from the initial selection of the behavior to its final generation. A long-standing research interest is how single neural networks can help generate different motor behaviors, that is, the origin of motor f...

journal_title：Current opinion in neurobiology

authors： Büschges A

更新日期：2012-08-01 00:00:00

abstract：:Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the pre...

journal_title：Current opinion in neurobiology

authors： Heusser K,Schwappach B

更新日期：2005-06-01 00:00:00

abstract：:mRNA localization and regulated translation take central roles in axon guidance and synaptic plasticity. By spatially restricting gene expression within neurons, local protein synthesis provides growth cones and synapses with the capacity to autonomously regulate their structure and function. Studies in a variety of s...

journal_title：Current opinion in neurobiology

authors： Martin KC

更新日期：2004-06-01 00:00:00

abstract：:Sexual communication can evolve in response to sexual selection, and it can also cause behavioral reproductive isolation between populations and thus drive speciation. Anurans are an excellent system to investigate these links between behavior and evolution because we have detailed knowledge of how neural mechanisms g...

journal_title：Current opinion in neurobiology

authors： Ryan MJ,Guerra MA

更新日期：2014-10-01 00:00:00

abstract：:Neuroscience research has become increasingly reliant upon quantitative and computational data analysis and modeling techniques. However, the vast majority of neuroscientists are still trained within the traditional biology curriculum, in which computational and quantitative approaches beyond elementary statistics may...

journal_title：Current opinion in neurobiology

authors： Goldman MS,Fee MS

更新日期：2017-10-01 00:00:00

abstract：:The impact of microarray studies on neurobiology has been limited because, with the exception of a few outstanding papers, most reports provide little more than lists of genes, often leaving the reader at a loss to understand which and how many of the identified transcripts will be true positives with significant biol...

journal_title：Current opinion in neurobiology

authors： Henry GL,Zito K,Dubnau J

更新日期：2003-10-01 00:00:00

abstract：:Biology provides examples of efficient machines which greatly outperform conventional technology. Designers in neuromorphic engineering aim to construct electronic systems with the same efficient style of computation. This task requires a melding of novel engineering principles with knowledge gleaned from neuroscience...

journal_title：Current opinion in neurobiology

authors： Liu SC,Delbruck T

更新日期：2010-06-01 00:00:00

abstract：:The discovery of hair cell regeneration in the inner ear of birds provides new optimism that there may be a treatment for hearing and balance disorders. In this review we describe the process of hair cell regeneration in birds; including restoration of function, recovery of perception and what is currently known about...

journal_title：Current opinion in neurobiology

authors： Bermingham-McDonogh O,Rubel EW

更新日期：2003-02-01 00:00:00

abstract：:In a similar fashion to transcription factors, non-coding RNAs can be essential regulators of gene expression. The largest class of non-coding RNAs is the microRNAs. These approximately 22 nt double-stranded RNA molecules can repress translation or target mRNA degradation. There has been a surge of research in the pas...

journal_title：Current opinion in neurobiology

authors： Klein ME,Impey S,Goodman RH

更新日期：2005-10-01 00:00:00

abstract：:It has been suggested that many aspects of reward-guided behaviour can be understood within the framework of a computational account of decision making. The account emphasises representation of expectations about decision outcomes and the revision of future expectations in the light of the prediction error-the discrep...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Mars RB,Summerfield C

更新日期：2009-02-01 00:00:00

abstract：:Genetic approaches at the neuromuscular synapse are leading investigation into the mechanisms of synaptogenesis. The marriage of classical (forward) and reverse genetic techniques allows the isolation and analysis of novel proteins involved in synaptic maturation and the functional in vivo characterization of previous...

journal_title：Current opinion in neurobiology

authors： Broadie K

更新日期：1998-02-01 00:00:00