Lessons for circuit function from large insects: towards understanding the neural basis of motor flexibility.

abstract：:Several advances have been made recently in characterizing neural progenitor cells. In vertebrates, multipotential stem cells have been demonstrated in the developing forebrain both in vitro and in vivo, and a class of stem cells has been identified in the adult CNS. Factors that regulate the proliferation and differe...

journal_title：Current opinion in neurobiology

authors： Temple S,Qian X

更新日期：1996-02-01 00:00:00

abstract：:AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the...

journal_title：Current opinion in neurobiology

authors： Anggono V,Huganir RL

更新日期：2012-06-01 00:00:00

abstract：:Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

journal_title：Current opinion in neurobiology

authors： Hernik M,Csibra G

更新日期：2009-02-01 00:00:00

abstract：:Visual attention operates by biasing competitive interactions between neural representations, favoring relevant over irrelevant visual inputs. Attention can enhance the processing of relevant information using location-based, feature-based or object-based selection mechanisms. Studies using event-related potential and...

journal_title：Current opinion in neurobiology

authors： Hopf JM,Schoenfeld MA,Heinze HJ

更新日期：2005-04-01 00:00:00

abstract：:Recent advances in the identification of factors that inhibit axon extension lead us to suggest that there exist at least two functionally distinct categories of inhibitory factors: those that inhibit the motile apparatus of the growth cone, and those that destabilize interactions of the growth cone with the substratu...

journal_title：Current opinion in neurobiology

authors： Luo Y,Raper JA

更新日期：1994-10-01 00:00:00

abstract：:Recent studies show that anatomical and functional brain networks exhibit similar small-world properties. However, the networks that are compared often differ in what the nodes represent (e.g. sensors or brain areas), what kind of connectivity is measured, and what temporal and spatial scales are probed. Here, I revie...

journal_title：Current opinion in neurobiology

authors： Ioannides AA

更新日期：2007-04-01 00:00:00

abstract：:Quantal neurotransmitter release at nerve terminals is tightly regulated by the presynaptic Ca2+ concentration. Here, we summarise current advances in understanding how the interplay between presynaptic Ca2+ dynamics and different Ca2+ release sensors shapes action potential-evoked release on a timescale from hundreds...

journal_title：Current opinion in neurobiology

authors： Volynski KE,Krishnakumar SS

更新日期：2018-08-01 00:00:00

abstract：:One of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), serves as a retrograde messenger at various types of synapses throughout the brain. Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neuro...

journal_title：Current opinion in neurobiology

authors： Ohno-Shosaku T,Kano M

更新日期：2014-12-01 00:00:00

abstract：:Sex steroid hormones exert a profound influence on the sexual differentiation and function of the neural circuits that mediate dimorphic behaviors. Both estrogen and testosterone are essential for male typical behaviors in many species. Recent studies with genetically modified mice provide important new insights into ...

journal_title：Current opinion in neurobiology

authors： Wu MV,Shah NM

更新日期：2011-02-01 00:00:00

abstract：:Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the pre...

journal_title：Current opinion in neurobiology

authors： Heusser K,Schwappach B

更新日期：2005-06-01 00:00:00

abstract：:The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the re...

journal_title：Current opinion in neurobiology

authors： Breer H,Boekhoff I

更新日期：1992-08-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:Over the past decade, developmental neuroscience has been transformed by the widespread application of confocal and two-photon fluorescence microscopy. Even greater progress is imminent, as recent innovations in microscopy now enable imaging with increased depth, speed, and spatial resolution; reduced phototoxicity; a...

journal_title：Current opinion in neurobiology

authors： Wu Y,Christensen R,Colón-Ramos D,Shroff H

更新日期：2013-12-01 00:00:00

abstract：:Huntington's disease (HD), a dominantly inherited neurodegenerative disease, is defined by its genetic cause, a CAG-repeat expansion in the HTT gene, its motor and psychiatric symptomology and primary loss of striatal medium spiny neurons (MSNs). However, the molecular mechanisms from genetic lesion to disease phenoty...

journal_title：Current opinion in neurobiology

authors： Veldman MB,Yang XW

更新日期：2018-02-01 00:00:00

abstract：:Of the few animal groups that learn their vocalizations, songbirds are uniquely amenable to molecular, physiological, and behavioral analyses of the neural features responsible for vocal learning. In order to communicate effectively as an adult, a young songbird recognizes and memorizes a model of his species-specific...

journal_title：Current opinion in neurobiology

authors： White SA

更新日期：2001-08-01 00:00:00

abstract：:Regulated release of neurotransmitter depends on the orchestrated function of a large number of proteins in the presynaptic compartment. When synaptic vesicles fuse with the plasma membrane, these membranes and the attached proteins are endocytosed and either recycled or degraded. This turnover needs to be tightly reg...

journal_title：Current opinion in neurobiology

authors： Lüningschrör P,Sendtner M

更新日期：2018-08-01 00:00:00

abstract：:Vision research has traditionally been studied in stationary subjects observing stimuli, and rarely during navigation. Recent research using virtual reality environments for mice has revealed that responses even in the primary visual cortex are modulated by spatial context - identical scenes presented in different pos...

journal_title：Current opinion in neurobiology

authors： Saleem AB

更新日期：2020-10-01 00:00:00

abstract：:General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class pr...

journal_title：Current opinion in neurobiology

authors： Akeju O,Brown EN

更新日期：2017-06-01 00:00:00

abstract：:A long-standing hypothesis postulates that the striatum is essential for the concurrent selection of adaptive actions and repression of inappropriate alternatives. Here, classical and recent anatomical and physiological studies are reviewed to show that, in mammals, the striatum can detect discrete task-relevant senso...

journal_title：Current opinion in neurobiology

authors： Robbe D

更新日期：2018-10-01 00:00:00

abstract：:Stimulus-driven gene expression is a ubiquitous feature of biological systems, allowing cells and organisms to adapt their function in a stimulus-driven manner. Neurons exhibit complex and heterogeneous activity-dependent gene expression, but many of the canonical mechanisms that transduce electrical activity into gen...

journal_title：Current opinion in neurobiology

authors： Heinz DA,Bloodgood BL

更新日期：2020-08-01 00:00:00

abstract：:Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...

journal_title：Current opinion in neurobiology

authors： McGehee DS,Role LW

更新日期：1996-06-01 00:00:00

abstract：:Functional magnetic resonance imaging (fMRI) and positron emission tomography measure local changes in brain hemodynamics induced by cognitive or perceptual tasks. These measures have a uniformly high spatial resolution of millimeters or less, but poor temporal resolution (about 1s). Conversely, electroencephalography...

journal_title：Current opinion in neurobiology

authors： Dale AM,Halgren E

更新日期：2001-04-01 00:00:00

abstract：:A recent series of exciting observations, using novel high-resolution time-lapse imaging of living cells, has provoked a major shift in our understanding of the dendritic spine, from a stable storage site of long-term memory to a dynamic structure that undergoes rapid morphological variations. Through these recent obs...

journal_title：Current opinion in neurobiology

authors： Segal M,Andersen P

更新日期：2000-10-01 00:00:00

abstract：:Databases of consistent, directed- and weighted inter-areal connectivity for mouse, macaque and marmoset monkeys have recently become available and begun to be used to build structural and dynamical models. A structural hierarchy can be defined based by laminar patterns of cortical connections. A large-scale dynamical...

journal_title：Current opinion in neurobiology

authors： Wang XJ,Pereira U,Rosa MG,Kennedy H

更新日期：2020-12-01 00:00:00

abstract：:Neurofilaments are proteins selectively expressed in the cytoskeleton of neurons, and increased levels are a marker of damage. Elevated neurofilament levels can serve as a marker of ongoing disease activity as well as a tool to measure response to therapeutic intervention. The potential utility of neurofilaments has d...

journal_title：Current opinion in neurobiology

authors： Gordon BA

更新日期：2020-04-01 00:00:00

abstract：:Recent results have shown the possibility of both reconstructing connectomes of small but biologically interesting circuits and extracting from these connectomes insights into their function. However, these reconstructions were heroic proof-of-concept experiments, requiring person-months of effort per neuron reconstru...

journal_title：Current opinion in neurobiology

authors： Plaza SM,Scheffer LK,Chklovskii DB

更新日期：2014-04-01 00:00:00

abstract：:Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are p...

journal_title：Current opinion in neurobiology

authors： Zufall F,Shepherd GM,Barnstable CJ

更新日期：1997-06-01 00:00:00

abstract：:The cadherin superfamily is a large (now more than 100 proteins) protein family originally identified as cell adhesion molecules. Each cadherin shows distinct expression patterns in the nervous system, and their expressions are both spatially and temporally regulated and diverse among different species. Mounting evide...

journal_title：Current opinion in neurobiology

authors： Matsunaga E,Okanoya K

更新日期：2014-10-01 00:00:00

abstract：:Comparative studies over the past year have revealed two new insights into the role of neuropeptides in the evolution of social behaviors. First, across vertebrate taxa, certain neuropeptide effects appear to be gender-specific. Second, species variations in receptor gene structure can alter neuropeptide receptor dist...

journal_title：Current opinion in neurobiology

authors： Insel TR,Young LJ

更新日期：2000-12-01 00:00:00

abstract：:Recent work has established that different geometric arrangements of calcium channels are found at different presynaptic terminals, leading to a wide spectrum of calcium signals for triggering neurotransmitter release. These calcium signals are apparently transduced by synaptotagmins - calcium-binding proteins found i...

journal_title：Current opinion in neurobiology

authors： Augustine GJ

更新日期：2001-06-01 00:00:00