Dendritic spines shaped by synaptic activity.

Abstract:

:A recent series of exciting observations, using novel high-resolution time-lapse imaging of living cells, has provoked a major shift in our understanding of the dendritic spine, from a stable storage site of long-term memory to a dynamic structure that undergoes rapid morphological variations. Through these recent observations, the molecular mechanisms underlying spine plasticity are beginning to emerge. A common mechanism involving changes in intracellular Ca(2+) concentration may control both the formation/elongation and the pruning/retraction of spines. Spine motility may be instrumental in the formation of synapses, may contribute to the anchoring/removing of glutamate receptors at spine heads, and may control the efficacy of existing synapses.

journal_name

Curr Opin Neurobiol

authors

Segal M,Andersen P

doi

10.1016/s0959-4388(00)00123-9

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

582-6

issue

5

eissn

0959-4388

issn

1873-6882

pii

S0959-4388(00)00123-9

journal_volume

10

pub_type

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