Abstract:
:A recent series of exciting observations, using novel high-resolution time-lapse imaging of living cells, has provoked a major shift in our understanding of the dendritic spine, from a stable storage site of long-term memory to a dynamic structure that undergoes rapid morphological variations. Through these recent observations, the molecular mechanisms underlying spine plasticity are beginning to emerge. A common mechanism involving changes in intracellular Ca(2+) concentration may control both the formation/elongation and the pruning/retraction of spines. Spine motility may be instrumental in the formation of synapses, may contribute to the anchoring/removing of glutamate receptors at spine heads, and may control the efficacy of existing synapses.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Segal M,Andersen Pdoi
10.1016/s0959-4388(00)00123-9subject
Has Abstractpub_date
2000-10-01 00:00:00pages
582-6issue
5eissn
0959-4388issn
1873-6882pii
S0959-4388(00)00123-9journal_volume
10pub_type
杂志文章,评审abstract::The striatum is a hub in the basal ganglia circuitry controlling goal directed actions and habits. The loss of its dopaminergic (DAergic) innervation in Parkinson's disease (PD) disrupts the ability of the two principal striatal projection systems to respond appropriately to cortical and thalamic signals, resulting in...
journal_title:Current opinion in neurobiology
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abstract::Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::In the mammalian cortex, the classic view assumes that the output information of a neuron is encoded in rather stereotyped action potentials, which provide an all-or-none or digital way of communication between cell body and axonal boutons. A role for subthreshold signal propagation within cortical axons has largely b...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Despite considerable skepticism, researchers have found that the patterns of muscle activation that control feeding behaviors of lower vertebrates have been surprisingly conserved during evolution. This tendency for conservation among taxa appears in the face of marked flexibility of motor patterns within individuals....
journal_title:Current opinion in neurobiology
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abstract::Biology provides examples of efficient machines which greatly outperform conventional technology. Designers in neuromorphic engineering aim to construct electronic systems with the same efficient style of computation. This task requires a melding of novel engineering principles with knowledge gleaned from neuroscience...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::Expression of vnd in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous gene families in corresponding domains of vertebrate neurectoderm, suggests that elements of dorsoventral neural patterning have been evolutionarily conserved. However, upstream signaling pathways regula...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.10.008
更新日期:2015-06-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.05.006
更新日期:2016-10-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Molecular mechanisms involved in the various stages of transmitter secretion have been studied by perturbing the composition of secretory cells using pharmacological and biochemical agents. An emerging approach is to reconstitute individual steps or the entire sequence of secretion mechanisms in non-secretory cells by...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(02)00307-0
更新日期:2002-04-01 00:00:00
abstract::Helping involves other-oriented actions that have the potential to benefit another. The last ten years has seen the introduction of several experimental paradigms to study helping in rats. In the best characterized of these, a free rat opens a door to release a rat trapped in an acrylic tube or pool of water. Helping ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2021.01.001
更新日期:2021-01-23 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00232-4
更新日期:2001-08-01 00:00:00
abstract::Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca(2+)-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.01.008
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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更新日期:2003-02-01 00:00:00
abstract::The prominent view that the rodent hippocampus is dedicated to spatial memory has been challenged recently by observations that both limit the nature of hippocampal spatial representation and extend its scope beyond literal space. These findings reveal that the rodent hippocampus mediates memory representations on the...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:1996-04-01 00:00:00
abstract::Both mammals and birds can flexibly organize their behavior over time. In mammals, the mental operations generating this ability are called executive functions and are associated with the prefrontal cortex. The corresponding structure in birds is the nidopallium caudolaterale. Anatomical, neurochemical, electrophysiol...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.10.003
更新日期:2005-12-01 00:00:00
abstract::Here I review the diversity of GABAergic neurons in the rodent basolateral amygdala (BLA). In spite of the recent identification of the role played by certain neurons of BLA in learning and memory of fear, the diversity of GABAergic neurons has not been fully explored. I describe analogies and differences between GABA...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.01.006
更新日期:2014-06-01 00:00:00
abstract::In the past year, our knowledge of neurotransmitter transporters has increased significantly. Recently, new members of two families of plasma membrane uptake carriers have been cloned, and the stoichiometries, physiological function and mechanisms of modulation of some of these transporters are now better understood. ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(94)90096-5
更新日期:1994-06-01 00:00:00
abstract::Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.04.007
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abstract::Sleep has been universally conserved across animal species. The basic functions of sleep remain unclear, but insufficient sleep impairs memory acquisition and retention in both vertebrates and invertebrates. Sleep is also a homeostatic process that is influenced not only by the amount of time awake, but also by neural...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.10.006
更新日期:2019-02-01 00:00:00
abstract::Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messe...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:1995-06-01 00:00:00
abstract::This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(93)90154-q
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