Abstract:
:One of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), serves as a retrograde messenger at various types of synapses throughout the brain. Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neurotransmitter release. When CB1 receptor activation is combined with some other factors such as presynaptic activity, the suppression is converted to a long-lasting form. Whereas 2-AG primarily transmits a rapid, transient, point-to-point retrograde signal, the other major endocannabinoid, anandamide, may function as a relatively slow retrograde or non-retrograde signal or as an agonist of the vanilloid receptor. The endocannabinoid system can be up- or down-regulated by a variety of physiological and environmental factors including stress, which might be clinically important.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Ohno-Shosaku T,Kano Mdoi
10.1016/j.conb.2014.03.017subject
Has Abstractpub_date
2014-12-01 00:00:00pages
1-8eissn
0959-4388issn
1873-6882pii
S0959-4388(14)00074-9journal_volume
29pub_type
杂志文章,评审abstract::A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance a...
journal_title:Current opinion in neurobiology
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