Zebrafish sleep: from geneZZZ to neuronZZZ.

abstract：:Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the ...

journal_title：Current opinion in neurobiology

authors： Vitureira N,Letellier M,Goda Y

更新日期：2012-06-01 00:00:00

abstract：:The established function of oligodendrocytes and their progenitors is to drive the cellular events of myelination, a highly diversified process necessary to match the needs of various neuronal subtypes and networks. The morphological and molecular heterogeneity of oligodendrocytes and their progenitors point to functi...

journal_title：Current opinion in neurobiology

authors： Dimou L,Simons M

更新日期：2017-12-01 00:00:00

abstract：:Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...

journal_title：Current opinion in neurobiology

authors： Guardia CM,De Pace R,Mattera R,Bonifacino JS

更新日期：2018-08-01 00:00:00

abstract：:What I cannot create I do not understand - Richard Feynman 1978 Because primate cortical development exhibits numerous specific features, the mouse is an imperfect model for human cortical development. Expansion of supragranular neurons is an evolutionary feature characterizing the primate cortex. Increased production...

journal_title：Current opinion in neurobiology

authors： Kennedy H,Wianny F,Dehay C

更新日期：2020-10-21 00:00:00

abstract：:Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over a range of speeds, amplitudes and frequencies (vigor). Recent work has ...

journal_title：Current opinion in neurobiology

authors： Dudman JT,Krakauer JW

更新日期：2016-04-01 00:00:00

abstract：:The ionotropic GABA receptor (GABAAR) mediates fast inhibition in the brain. The GABAAR pore-forming (α, β, and non-α/β) subunits were isolated approximately 30 years ago and have since been the focus of extensive studies. As a result, many properties of GABAARs, including subunit assembly and channel and pharmacologi...

journal_title：Current opinion in neurobiology

authors： Tomita S

更新日期：2019-08-01 00:00:00

abstract：:Circadian clocks organize neural processes, such as motor activities, into near 24-hour oscillations and adaptively synchronize these rhythms to the solar cycle. Recently, the first mammalian clock genes have been found. Unpredicted diversity in signaling pathways and clock-controlled gating of signals that modulate t...

journal_title：Current opinion in neurobiology

authors： Gillette MU

更新日期：1997-12-01 00:00:00

abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

journal_title：Current opinion in neurobiology

authors： Griffith LC

更新日期：2012-08-01 00:00:00

abstract：:The anterior cingulate cortex (ACC) and adjacent areas of the medial frontal cortex (MFC) have been implicated in monitoring behaviour and in detecting errors. Recent evidence, however, suggests that the ACC not only registers the occurrence of errors but also represents other aspects of the reinforcement history that...

journal_title：Current opinion in neurobiology

authors： Rushworth MF,Buckley MJ,Behrens TE,Walton ME,Bannerman DM

更新日期：2007-04-01 00:00:00

abstract：:Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...

journal_title：Current opinion in neurobiology

authors： Tillery SI,Taylor DM

更新日期：2004-12-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:Understanding how the brain performs computations requires understanding neuronal firing patterns at successive levels of processing-a daunting and seemingly intractable task. Two recent studies have made dramatic progress on this problem by showing how its dimensionality can be reduced. Using the retina as a model sy...

journal_title：Current opinion in neurobiology

authors： Nirenberg SH,Victor JD

更新日期：2007-08-01 00:00:00

abstract：:The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complet...

journal_title：Current opinion in neurobiology

authors： Sasaki T,Leutgeb S,Leutgeb JK

更新日期：2015-06-01 00:00:00

abstract：:This review covers the dynamic regulation of neuroligin isoforms, focusing on posttranslational events including phosphorylation, glycosylation and activity-dependent cleavage. There is a growing literature on how phosphorylation confers an isoform-specific level of modulation affecting a variety of protein interactio...

journal_title：Current opinion in neurobiology

authors： Jeong J,Paskus JD,Roche KW

更新日期：2017-08-01 00:00:00

abstract：:Cyclic-nucleotide-gated (CNG) channels play key roles in photoreceptor and olfactory signal-transduction pathways. Recent studies have focused on the molecular characterization of CNG channel subunits and on the identification of the structural domains that contribute to ligand selectivity and affinity, ion gating and...

journal_title：Current opinion in neurobiology

authors： Molday RS

更新日期：1996-08-01 00:00:00

abstract：:In the last few years, work in the nascent field of neuroeconomics has advanced understanding of the brain systems involved in value-based decision making. An important modulator of valuation processes is the specific context a decision maker is facing during choice. Recently, neuroeconomics has made great progress in...

journal_title：Current opinion in neurobiology

authors： Tymula A,Plassmann H

更新日期：2016-10-01 00:00:00

abstract：:Voltage-gated ion channels are composed of pore-forming subunits, as well as auxiliary subunits that modify the functions of these channels. In addition, the channels interact with other modulatory proteins in a more transient manner, although with significant effects on channel activity. Even though many second-messe...

journal_title：Current opinion in neurobiology

authors： Adelman JP

更新日期：1995-06-01 00:00:00

abstract：:Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided st...

journal_title：Current opinion in neurobiology

authors： Linden DJ,Connor JA

更新日期：1993-06-01 00:00:00

abstract：:The emergence of neuronal diversity during development of the nervous system relies on dynamic changes in the epigenetic landscape of neural stem cells and their progeny. Targeted DamID (TaDa) is proving invaluable in identifying the genome-wide binding sites of chromatin-associated proteins in vivo, without fixation,...

journal_title：Current opinion in neurobiology

authors： van den Ameele J,Krautz R,Brand AH

更新日期：2019-06-01 00:00:00

abstract：:The search for quantifiable biological mediators of genetic risk or 'intermediate phenotypes' is an essential strategy in psychiatric neuroscience and a useful tool for exploring the complex relationships between genes, neural circuits and behaviors. In recent years, the examination of connectivity-based intermediate ...

journal_title：Current opinion in neurobiology

authors： Cao H,Dixson L,Meyer-Lindenberg A,Tost H

更新日期：2016-02-01 00:00:00

abstract：:The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...

journal_title：Current opinion in neurobiology

authors： Linster C,Cleland TA

更新日期：2016-10-01 00:00:00

abstract：:Ca2+ entry into neurons is one of the major effectors of stimulus-induced physiological change. Ca2+ can enter neurons through a number of different voltage-gated and ligand-gated channels. Depending on the route of entry, Ca2+ stimulates distinct intracellular signaling pathways, which activate different sets of gene...

journal_title：Current opinion in neurobiology

authors： Gallin WJ,Greenberg ME

更新日期：1995-06-01 00:00:00

abstract：:The visual system is tasked with extracting stimulus content (e.g. the identity of an object) from the spatiotemporal light pattern falling on the retina. However, visual information can be ambiguous with regard to content (e.g. an object when viewed from far away), requiring the system to also consider contextual inf...

journal_title：Current opinion in neurobiology

authors： Rust NC,Stocker AA

更新日期：2010-06-01 00:00:00

abstract：:The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the re...

journal_title：Current opinion in neurobiology

authors： Breer H,Boekhoff I

更新日期：1992-08-01 00:00:00

abstract：:A long standing goal in motor control is to determine the fundamental output controlled by the CNS: does the CNS control the activation of individual motor units, individual muscles, groups of muscles, kinematic or dynamic features of movement, or does it simply care about accomplishing a task? Of course, the output c...

journal_title：Current opinion in neurobiology

authors： Tresch MC,Jarc A

更新日期：2009-12-01 00:00:00

abstract：:The mechanisms for delivering components to nerve terminals are diverse and highly regulated. The diversity of kinesin motors alone is insufficient to account for the specificity of delivery. Additional specificity and control are contributed by adaptor proteins and associated regulatory molecules. The interaction of ...

journal_title：Current opinion in neurobiology

authors： Goldstein AY,Wang X,Schwarz TL

更新日期：2008-10-01 00:00:00

abstract：:Neuroepithelial cells, the progenitors to the CNS neurons and glia, undergo both symmetric and asymmetric divisions. Symmetric divisions underlie the proliferation of neuroepithelial cells that predominates early in CNS development. Asymmetric divisions are thought to generate the cell types derived from neuroepitheli...

journal_title：Current opinion in neurobiology

authors： Huttner WB,Brand M

更新日期：1997-02-01 00:00:00

abstract：:The hippocampal formation has a unique and highly distributed network of intrinsic connections. What are the principles of organization that govern information flow through this system? The notion that information processing in the hippocampal formation is segregated in autonomous chips or lamellae appears to be incon...

journal_title：Current opinion in neurobiology

authors： Amaral DG

更新日期：1993-04-01 00:00:00

abstract：:Facial interactions are prominent behaviors in primates. Primate facial signaling, which includes the expression of emotions, mimicking of facial movements, and gaze interactions, is visually dominated. Correspondingly, in primate brains an elaborate network of face processing areas exists within visual cortex. But ot...

journal_title：Current opinion in neurobiology

authors： Brecht M,Freiwald WA

更新日期：2012-04-01 00:00:00

abstract：:Plasma membrane Cl- channels perform a variety of functions, including control of excitability in neurons and muscle, cell volume regulation and transepithelial transport. Structurally, three classes of Cl- channels have been identified: ligand-gated, postsynaptic Cl- channels (e.g. GABA and glycine receptors); the cy...

journal_title：Current opinion in neurobiology

authors： Jentsch TJ

更新日期：1996-06-01 00:00:00