Axonal transport and the delivery of pre-synaptic components.

Abstract:

:The mechanisms for delivering components to nerve terminals are diverse and highly regulated. The diversity of kinesin motors alone is insufficient to account for the specificity of delivery. Additional specificity and control are contributed by adaptor proteins and associated regulatory molecules. The interaction of cargos with these complexes can confer distinct behaviors on the transport of synaptic organelles. The rich regulatory mechanisms of transport that are only now emerging as the cargo-motor complexes are defined and subsequent local events that regulate their dynamic relationship are examined. Here we review recent studies of kinesin-related axonal transport of three crucial synaptic components, Piccolo-bassoon Transport Vesicles (PTVs), Synaptic Vesicle Precursors (SVPs), and mitochondria, and the mechanisms that modulate their transport.

journal_name

Curr Opin Neurobiol

authors

Goldstein AY,Wang X,Schwarz TL

doi

10.1016/j.conb.2008.10.003

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

495-503

issue

5

eissn

0959-4388

issn

1873-6882

pii

S0959-4388(08)00130-X

journal_volume

18

pub_type

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