Abstract:
:Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes named AP-1 through AP-5. AP complexes play important roles in all cells, but their functions are most critical in neurons because of the extreme compartmental complexity of these cells. Accordingly, various diseases caused by mutations in AP subunit genes exhibit a range of neurological abnormalities as their most salient features. In this article, we discuss the properties of the different AP complexes, with a focus on their roles in neuronal physiology and pathology.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Guardia CM,De Pace R,Mattera R,Bonifacino JSdoi
10.1016/j.conb.2018.02.021subject
Has Abstractpub_date
2018-08-01 00:00:00pages
103-110eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30317-3journal_volume
51pub_type
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