Abstract：
:Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cortical and central nuclei of the amygdala and the medial septum. As neurogenesis occurs for these different neuron types during approximately the fifth week of gestation, the possibility is raised that this may be a 'window of vulnerability' for autism; the likely etiologic heterogeneity of autism suggests that other windows of vulnerability are also possible.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Courchesne Edoi
10.1016/s0959-4388(97)80016-5subject
Has Abstractpub_date
1997-04-01 00:00:00pages
269-78issue
2eissn
0959-4388issn
1873-6882pii
S0959-4388(97)80016-5journal_volume
7pub_type
杂志文章,评审abstract：:The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mecha...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2010.03.011
更新日期：2010-08-01 00:00:00
abstract：:Sensory neurons are usually described with an encoding model, for example, a function that predicts their response from the sensory stimulus using a receptive field (RF) or a tuning curve. However, central to theories of sensory processing is the notion of 'efficient coding'. We argue here that efficient coding implie...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.03.002
更新日期：2016-04-01 00:00:00
abstract：:Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided st...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(93)90133-j
更新日期：1993-06-01 00:00:00
abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.03.006
更新日期：2017-08-01 00:00:00
abstract：:Central pattern generators are subject to extensive modulation that generates flexibility in the rhythmic outputs of these neural networks. The effects of neuromodulators interact with one another, and modulatory neurons are themselves often subject to modulation, enabling both higher order control and indirect intera...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2006.10.007
更新日期：2006-12-01 00:00:00
abstract：:Synapses are functional units of the nervous system, through which information is transferred between neurons. The development and activity-dependent modification of synapses require temporally and spatially controlled modulation of gene expression. microRNAs (miRNAs) have emerged as essential regulators of gene expre...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.02.014
更新日期：2017-08-01 00:00:00
abstract：:Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelect...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.12.009
更新日期：2018-06-01 00:00:00
abstract：:MicroRNAs (miRNAs) are a recently discovered, extensive class of small noncoding RNAs that act as post-transcriptional regulators of gene expression. miRNAs have been implicated in most aspects of animal development and in pathological processes such as cancer. In neurons, miRNAs are expressed at all stages of develop...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2009.05.015
更新日期：2009-04-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) is used widely to determine the spatial layout of brain activation associated with specific cognitive tasks at a spatial scale of millimeters. Recent methodological improvements have made it possible to determine the latency and temporal structure of the activation at a tem...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(03)00044-8
更新日期：2003-04-01 00:00:00
abstract：:The development of motor behaviour depends on the differentiation of underlying circuitry. Recent work with the zebrafish brings the simple swimming behaviour of lower vertebrates and their embryos into focus as a suitable model to study the development of motor circuitry and its genetic control. Changes in connectivi...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(99)00031-8
更新日期：1999-12-01 00:00:00
abstract：:Chronic administration of opiates or cocaine has been shown to alter the activity or expression of diverse types of cellular proteins in specific target neurons within the central nervous system. Prominent examples include signaling proteins, such as receptors, G proteins, second-messenger synthetic enzymes, and prote...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(97)80094-3
更新日期：1997-10-01 00:00:00
abstract：:The mechanisms for delivering components to nerve terminals are diverse and highly regulated. The diversity of kinesin motors alone is insufficient to account for the specificity of delivery. Additional specificity and control are contributed by adaptor proteins and associated regulatory molecules. The interaction of ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2008.10.003
更新日期：2008-10-01 00:00:00
abstract：:Cognitive neuroimaging maps the brain locations of mental operations. This process is iterative, as no single study can fully characterize a mental operation or its brain location. This iterative discovery process, in combination with the location-reporting standard (i.e. spatial coordinates) of the cognitive neuroima...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80138-4
更新日期：1998-04-01 00:00:00
abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(96)80099-7
更新日期：1996-10-01 00:00:00
abstract：:The study of plasticity in the central nervous system is a major and very dynamic neuroscience research field with enormous clinical potential. Considerable advances in this field have been made during the past 10 years. It now appears that most circuits in the brain and spinal cord show plasticity and that they can b...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2004.10.009
更新日期：2004-12-01 00:00:00
abstract：:Emerging evidences linking pathological mechanisms of prions and tauopathies are accumulating. However, Tau assemblies do not yet fulfill all the criteria of prions. Here, we review recent data pointing similarities between prions and tauopathies and discuss the still existing uncertainties. ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2019.11.022
更新日期：2020-04-01 00:00:00
abstract：:The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complet...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.10.008
更新日期：2015-06-01 00:00:00
abstract：:The ability to make accurate predictions of future stimuli and consequences of one's actions are crucial for the survival and appropriate decision-making. These predictions are constantly being made at different levels of the nervous system. This is evidenced by adaptation to stimulus parameters in sensory coding, and...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.11.007
更新日期：2014-04-01 00:00:00
abstract：:Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.04.004
更新日期：2017-06-01 00:00:00
abstract：:The suprachiasmatic nucleus of the hypothalamus and at least two other unidentified central pacemakers regulate the temporal structure of a circadian network that involves almost every organ in the body. Phase control is central to the efficient function of this system. Individual circadian oscillators in tissues and ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.03.003
更新日期：2013-10-01 00:00:00
abstract：:Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that ser...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2020.02.010
更新日期：2020-08-01 00:00:00
abstract：:The crustacean stomatogastric nervous system is a long-standing test bed for studies of circuit dynamics and neuromodulation. We give a brief update on the most recent work on this system, with an emphasis on the broader implications for understanding neural circuits. In particular, we focus on new findings underlinin...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.07.005
更新日期：2016-12-01 00:00:00
abstract：:Here I review the diversity of GABAergic neurons in the rodent basolateral amygdala (BLA). In spite of the recent identification of the role played by certain neurons of BLA in learning and memory of fear, the diversity of GABAergic neurons has not been fully explored. I describe analogies and differences between GABA...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.01.006
更新日期：2014-06-01 00:00:00
abstract：:A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/S0959-4388(99)80066-X
更新日期：1999-08-01 00:00:00
abstract：:Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2004.10.013
更新日期：2004-12-01 00:00:00
abstract：:Accepting, rejecting or modifying the many different theories of the cerebellum's role in the control of movement requires an understanding of the signals encoded in the discharge of cerebellar neurons and how those signals are transformed by the cerebellar circuitry. Particularly challenging is understanding the sens...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80119-0
更新日期：1998-12-01 00:00:00
abstract：:Quantal neurotransmitter release at nerve terminals is tightly regulated by the presynaptic Ca2+ concentration. Here, we summarise current advances in understanding how the interplay between presynaptic Ca2+ dynamics and different Ca2+ release sensors shapes action potential-evoked release on a timescale from hundreds...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2018.05.006
更新日期：2018-08-01 00:00:00
abstract：:The insular cortex is the primary cortical site devoted to taste processing. A large body of evidence is available for how insular neurons respond to gustatory stimulation in both anesthetized and behaving animals. Most of the reports describe broadly tuned neurons that are involved in processing the chemosensory, phy...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2012.04.001
更新日期：2012-08-01 00:00:00
abstract：:Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster tha...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(03)00013-8
更新日期：2003-02-01 00:00:00
abstract：:The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology. Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses hav...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(96)80088-2
更新日期：1996-10-01 00:00:00
