Abstract:
:Müller Glia (MG), the radial glia cells of the retina, have spectacular morphologies subserving their enormous functional complexity. As early as 1892, the great neuroanatomist Santiago Ramon y Cajal studied the morphological development of MG, defining several steps in their morphogenesis [1,2]. However, the molecular cues controlling these developmental steps remain poorly understood. As MG have roles to play in every cellular and plexiform layer, this review discusses our current understanding on how MG morphology may be linked to their function, including the developmental mechanisms involved in MG patterning and morphogenesis. Uncovering the mechanisms governing glial morphogenesis, using transcriptomics and imaging, may provide shed new light on the pathophysiology and treatment of human neurological disorders.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
MacDonald RB,Charlton-Perkins M,Harris WAdoi
10.1016/j.conb.2017.08.005subject
Has Abstractpub_date
2017-12-01 00:00:00pages
31-37eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30219-2journal_volume
47pub_type
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