Forward and reverse genetic approaches to synaptogenesis.

abstract：:The behavioral repertoire of an organism can be highly diverse, spanning from social to defensive. How an animal efficiently switches between distinct behaviors is a fundamental question whose inquiry will provide insights into the mechanisms that are necessary for an organism's survival. Previous work aimed at identi...

journal_title：Current opinion in neurobiology

authors： Rozeske RR,Herry C

更新日期：2018-10-01 00:00:00

abstract：:Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...

journal_title：Current opinion in neurobiology

authors： Kording KP

更新日期：2014-04-01 00:00:00

abstract：:The impact of microarray studies on neurobiology has been limited because, with the exception of a few outstanding papers, most reports provide little more than lists of genes, often leaving the reader at a loss to understand which and how many of the identified transcripts will be true positives with significant biol...

journal_title：Current opinion in neurobiology

authors： Henry GL,Zito K,Dubnau J

更新日期：2003-10-01 00:00:00

abstract：:Processing of auditory information requires constant adjustment due to alterations of the environment and changing conditions in the nervous system with age, health, and experience. Consequently, patterns of activity in cortical networks have complex dynamics over a wide range of timescales, from milliseconds to days ...

journal_title：Current opinion in neurobiology

authors： Froemke RC,Schreiner CE

更新日期：2015-12-01 00:00:00

abstract：:One of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), serves as a retrograde messenger at various types of synapses throughout the brain. Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neuro...

journal_title：Current opinion in neurobiology

authors： Ohno-Shosaku T,Kano M

更新日期：2014-12-01 00:00:00

abstract：:During the past year,several model systems have been developed to identify cellular and biochemical events involved in neuronal cell death, to investigate the role of bcl-2 in cell survival, and to characterize the relationship between cell death and the cell cycle. ...

journal_title：Current opinion in neurobiology

authors： Pittman RN,Mills JC,DiBenedetto AJ,Hynicka WP,Wang S

更新日期：1994-02-01 00:00:00

abstract：:Coupled oscillations are hypothesized to organize the processing of information across distributed brain circuits. This idea is supported by recent evidence, and newly developed techniques promise to put such theoretical framework to mechanistic testing. We review evidence suggesting that individual oscillatory cycles...

journal_title：Current opinion in neurobiology

authors： Wilson MA,Varela C,Remondes M

更新日期：2015-04-01 00:00:00

abstract：:How does auditory cortex represent auditory stimuli, and how do these representations contribute to behavior? Recent experimental evidence suggests that activity in auditory cortex consists of sparse and highly synchronized volleys of activity, observed both in anesthetized and awake animals. Many neurons are capable ...

journal_title：Current opinion in neurobiology

authors： Hromádka T,Zador AM

更新日期：2009-08-01 00:00:00

abstract：:The fruit fly, Drosophila melanogaster, is equipped with a sophisticated olfactory sensory system that permits it to recognize and discriminate hundreds of discrete odorants. The perception of these odorants is essential for the animal to identify relevant food sources and suitable sites for egg-laying. Advances in th...

journal_title：Current opinion in neurobiology

authors： Vosshall LB

更新日期：2000-08-01 00:00:00

abstract：:Rhythms are a prominent signature of brain activity. Their expression is correlated with numerous examples of healthy information processing and their fluctuations are a marker of disease states. Yet, their causal or epiphenomenal role in brain function is still highly debated. We review recent studies showing brain r...

journal_title：Current opinion in neurobiology

authors： Jones SR

更新日期：2016-10-01 00:00:00

abstract：:Homeostatic synaptic plasticity remains an enigmatic form of synaptic plasticity. Increasing interest on the topic has fuelled a surge of recent studies that have identified key molecular players and the signaling pathways involved. However, the new findings also highlight our lack of knowledge concerning some of the ...

journal_title：Current opinion in neurobiology

authors： Vitureira N,Letellier M,Goda Y

更新日期：2012-06-01 00:00:00

abstract：:The suprachiasmatic nucleus of the hypothalamus and at least two other unidentified central pacemakers regulate the temporal structure of a circadian network that involves almost every organ in the body. Phase control is central to the efficient function of this system. Individual circadian oscillators in tissues and ...

journal_title：Current opinion in neurobiology

authors： Menaker M,Murphy ZC,Sellix MT

更新日期：2013-10-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00

abstract：:Sex differences in the nervous system are found throughout the animal kingdom. Here, we discuss three prominent genetic models: nematodes, fruit flies, and mice. In all three, differential cell death is central to sexual differentiation and shared molecular mechanisms have been identified. Our knowledge of the precise...

journal_title：Current opinion in neurobiology

authors： Forger NG,de Vries GJ

更新日期：2010-12-01 00:00:00

abstract：:The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...

journal_title：Current opinion in neurobiology

authors： Linster C,Cleland TA

更新日期：2016-10-01 00:00:00

abstract：:Research on spatial problem-solving over the past two years has linked the hippocampus to path integration, that is, the use of movement-related cues to guide spatial behavior. Path integration may underlie the forms of place learning that are impaired by hippocampal damage. It remains a challenge to determine whether...

journal_title：Current opinion in neurobiology

authors： Whishaw IQ,McKenna JE,Maaswinkel H

更新日期：1997-04-01 00:00:00

abstract：:The prominent view that the rodent hippocampus is dedicated to spatial memory has been challenged recently by observations that both limit the nature of hippocampal spatial representation and extend its scope beyond literal space. These findings reveal that the rodent hippocampus mediates memory representations on the...

journal_title：Current opinion in neurobiology

authors： Eichenbaum H

更新日期：1996-04-01 00:00:00

abstract：:Our ability to learn and control the motor aspects of complex laryngeal behaviors, such as speech and song, is modulated by the laryngeal motor cortex (LMC), which is situated in the area 4 of the primary motor cortex and establishes both direct and indirect connections with laryngeal motoneurons. In contrast, the LMC...

journal_title：Current opinion in neurobiology

authors： Simonyan K

更新日期：2014-10-01 00:00:00

abstract：:Rats sweep their vibrissae through space to locate objects in their immediate environment. In essence, their view of the proximal world is generated through pliable hairs that tap and palpate objects. The texture and shape of those objects must be discerned for the rat to assess the value of the object. Furthermore, t...

journal_title：Current opinion in neurobiology

authors： Kleinfeld D,Ahissar E,Diamond ME

更新日期：2006-08-01 00:00:00

abstract：:A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...

journal_title：Current opinion in neurobiology

authors： Carney LH

更新日期：1999-08-01 00:00:00

abstract：:Emerging evidences linking pathological mechanisms of prions and tauopathies are accumulating. However, Tau assemblies do not yet fulfill all the criteria of prions. Here, we review recent data pointing similarities between prions and tauopathies and discuss the still existing uncertainties. ...

journal_title：Current opinion in neurobiology

authors： Clavaguera F,Duyckaerts C,Haïk S

更新日期：2020-04-01 00:00:00

abstract：:Parenting is essential for survival and wellbeing in many species. Since it can be performed with little prior experience and entails considerable sacrifices without immediate benefits for the caregiver, this behavior is likely orchestrated by evolutionarily shaped, hard-wired neural circuits. At the same time, experi...

journal_title：Current opinion in neurobiology

authors： Kohl J

更新日期：2020-02-01 00:00:00

abstract：:Cell-cell communication directs the development of photoreceptor cells in the Drosophila retina. A recent set of studies has provided a genetic dissection of one of these interactions, the induction of the R7 photoreceptor cell by the neighboring R8 photoreceptor cell. The results from these experiments shape our unde...

journal_title：Current opinion in neurobiology

authors： Krämer H,Cagan RL

更新日期：1994-02-01 00:00:00

abstract：:Recent behavioral studies of infants have provided further evidence for the existence of cognitive and perceptual abilities in the first few months of life. Additional evidence from developmental neuroscience and comparative psychology has supported the view that, in some domains, such as visual attention and face and...

journal_title：Current opinion in neurobiology

authors： Johnson MH

更新日期：1994-04-01 00:00:00

abstract：:Standard economic theories conceive homo economicus as a rational decision maker capable of maximizing utility. In reality, however, people tend to approximate optimal decision-making strategies through a collection of heuristic routines. Some of these routines are driven by emotional processes, and others are adjuste...

journal_title：Current opinion in neurobiology

authors： Lee D

更新日期：2006-04-01 00:00:00

abstract：:Pruning, a process by which neurons selectively remove exuberant or unnecessary processes without causing cell death, is crucial for the establishment of mature neural circuits during animal development. Yet relatively little is known about molecular and cellular mechanisms that govern neuronal pruning. Holometabolous...

journal_title：Current opinion in neurobiology

authors： Yu F,Schuldiner O

更新日期：2014-08-01 00:00:00

abstract：:We present recent literature on model-based approaches to estimating functional connectivity from neuroimaging data. In contrast to the typical focus on a particular scientific question, we reframe a wider literature in terms of the underlying statistical model used. We distinguish between directed versus undirected a...

journal_title：Current opinion in neurobiology

authors： Foti NJ,Fox EB

更新日期：2019-04-01 00:00:00

abstract：:The pinnipeds provide a variety of clues to those interested in the vocal learning capabilities of non-human animals. Observational and experimental studies of seals, sea lions, and walruses reveal elements of vocal development, contextual control, plasticity in expression and learning, and even imitation of complex s...

journal_title：Current opinion in neurobiology

authors： Reichmuth C,Casey C

更新日期：2014-10-01 00:00:00

abstract：:A recent series of exciting observations, using novel high-resolution time-lapse imaging of living cells, has provoked a major shift in our understanding of the dendritic spine, from a stable storage site of long-term memory to a dynamic structure that undergoes rapid morphological variations. Through these recent obs...

journal_title：Current opinion in neurobiology

authors： Segal M,Andersen P

更新日期：2000-10-01 00:00:00

abstract：:During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there ...

journal_title：Current opinion in neurobiology

authors： Reiner O,Parichha A,Sapir T

更新日期：2020-10-15 00:00:00