Abstract：
:Prions cause transmissible and genetic neurodegenerative diseases. Infectious prion particles are composed largely, if not entirely, of an abnormal isoform of the prion protein (PrPSc), which is encoded by a chromosomal gene. Although the PrP gene is single copy, transgenic mice with both alleles of the PrP gene ablated develop normally. A post-translational process, as yet unidentified, converts the cellular prion protein (PrPC) into PrPSc. Scrapie incubation times, neuropathology and prion synthesis in transgenic mice are controlled by the PrP gene. Mutations in this gene are genetically linked to the development of neurodegeneration. Transgenic mice expressing mutant PrP spontaneously develop neurological dysfunction and spongiform neuropathology. Future investigations of prion diseases using molecular biological and genetic approaches promise to yield much new information about these once enigmatic disorders.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Prusiner SBdoi
10.1016/0959-4388(92)90032-gsubject
Has Abstractpub_date
1992-10-01 00:00:00pages
638-47issue
5eissn
0959-4388issn
1873-6882journal_volume
2pub_type
杂志文章,评审abstract：:Presynaptic nerve terminals release neurotransmitter synchronously, asynchronously or spontaneously. During synchronous neurotransmission release is precisely coupled to action potentials, in contrast, asynchronous release events show only loose temporal coupling to presynaptic activity whereas spontaneous neurotransm...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2018.03.005
更新日期：2018-08-01 00:00:00
abstract：:Animal life is rhythmic. Here we provide an overview of various rhythmic behaviors, connected environmental factors and endogenous mechanisms. We not only cover terrestrial species, but also highlight aquatic environments with typically complex interconnected rhythms. We further address diel, seasonal and potential lu...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2019.10.005
更新日期：2020-02-01 00:00:00
abstract：:Vertebrates are remarkable for their ability to select and execute goal-directed actions: motor skills critical for thriving in complex, competitive environments. A key aspect of a motor skill is the ability to execute its component movements over a range of speeds, amplitudes and frequencies (vigor). Recent work has ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.02.005
更新日期：2016-04-01 00:00:00
abstract：:Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2018.02.021
更新日期：2018-08-01 00:00:00
abstract：:Central core (brainstem, diencephalic and basal forebrain) systems influence the functional modes of thalamic and cortical neurons during behavioral states of vigilance. Recent studies in vivo and in vitro have focused on the cellular properties of central core systems and their modulation of slow sleep oscillations, ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(93)90064-6
更新日期：1993-08-01 00:00:00
abstract：:Neurons have a multiplicity of ionic conductance mechanisms, the interactions of which determine in part the response of a neuron to chemical and electrical synaptic interactions, firing patterns, excitability, membrane potential and action-potential waveform. Several papers published in the past year have provided im...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(91)90017-2
更新日期：1991-06-01 00:00:00
abstract：:'Auditory scenes' often contain contributions from multiple acoustic sources. These are usually heard as separate auditory 'streams', which can be selectively followed over time. How and where these auditory streams are formed in the auditory system is one of the most fascinating questions facing auditory scientists t...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2010.03.009
更新日期：2010-06-01 00:00:00
abstract：:Studies of the function of the basal forebrain have focused on cholinergic neurons that project to cortical and limbic structures critical for various cognitive abilities. Recent experiments suggest that these neurons serve a modulatory function in cognition, by optimizing cortical information processing and influenci...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(99)80024-5
更新日期：1999-04-01 00:00:00
abstract：:Nearly all studies of natural variation within clock genes involve the period (per) locus, which was originally isolated in the fruit-fly. Intra- and interspecific work on per has focused mostly on a region of Thr-Gly or Ser-Gly repeats, which show rapid length and sequence evolution. The functional implications of nu...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80096-2
更新日期：1998-10-01 00:00:00
abstract：:Cloning of the Huntington's disease gene uncovered huntingtin, which is remarkable for its lack of similarity with known proteins despite its large size, approximately 350 kDa. Subsequent experiments established that huntingtin has an as yet unknown function, crucial for embryonic development and neurogenesis. Recent ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80071-8
更新日期：1998-06-01 00:00:00
abstract：:The nervous system is evolutionarily conservative compared to the peripheral appendages that it controls. However, species-specific behaviors may have arisen from very small changes in neuronal circuits. In particular, changes in neuromodulatory systems may allow multifunctional circuits to produce different sets of b...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/S0959-4388(99)00012-4
更新日期：1999-10-01 00:00:00
abstract：:The astonishing cellular diversity in the central nervous system (CNS) arises from neural progenitors which can undergo different modes of symmetric and asymmetric divisions to self-renew as well as produce differentiated neuronal and glial progeny. Drosophila CNS neural progenitor cells, neuroblasts, have been utilis...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2008.05.002
更新日期：2008-02-01 00:00:00
abstract：:Motor behaviors result from information processing that occurs in multiple neural networks acting at all levels from the initial selection of the behavior to its final generation. A long-standing research interest is how single neural networks can help generate different motor behaviors, that is, the origin of motor f...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2012.02.003
更新日期：2012-08-01 00:00:00
abstract：:Cerebellar long-term depression is a persistent, input-specific attenuation of the parallel fiber-Purkinje neuron synapse induced by co-activation of parallel fibers and climbing fibers. This phenomenon endows the Purkinje neuron with a powerful associative computational ability. Recent investigations have provided st...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(93)90133-j
更新日期：1993-06-01 00:00:00
abstract：:Cell-cell communication directs the development of photoreceptor cells in the Drosophila retina. A recent set of studies has provided a genetic dissection of one of these interactions, the induction of the R7 photoreceptor cell by the neighboring R8 photoreceptor cell. The results from these experiments shape our unde...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(94)90026-4
更新日期：1994-02-01 00:00:00
abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2004.08.010
更新日期：2004-10-01 00:00:00
abstract：:A novel multigene family has been identified that is likely to encode odorant receptors on olfactory sensory neurons. Further studies on this gene family are likely to shed light on the molecular mechanisms underlying information coding in the mammalian olfactory system. This review is also published in Current Opinio...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(92)90116-3
更新日期：1992-06-01 00:00:00
abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2012.01.002
更新日期：2012-08-01 00:00:00
abstract：:In recent years, as our understanding of the pattern-generating networks responsible for a variety of behaviors has increased, the interactions of multiple neural networks have been examined in a number of systems. These studies have shown that functionally related pattern generators can interact extensively, and that...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(95)80108-1
更新日期：1995-12-01 00:00:00
abstract：:Analyzing data from experiments involves variables that we neuroscientists are uncertain about. Efficiently calculating with such variables usually requires Bayesian statistics. As it is crucial when analyzing complex data, it seems natural that the brain would "use" such statistics to analyze data from the world. And...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.01.003
更新日期：2014-04-01 00:00:00
abstract：:Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring. In this review, w...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2012.02.006
更新日期：2012-10-01 00:00:00
abstract：:Functional magnetic resonance imaging (fMRI) and positron emission tomography measure local changes in brain hemodynamics induced by cognitive or perceptual tasks. These measures have a uniformly high spatial resolution of millimeters or less, but poor temporal resolution (about 1s). Conversely, electroencephalography...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(00)00197-5
更新日期：2001-04-01 00:00:00
abstract：:High densities of acetylcholine receptors and sodium channels in the crests and troughs of the postsynaptic folds, respectively, ensure reliable neuromuscular signalling. Clustering of both ion channels is mediated by agrin. In the case of acetylcholine receptors, agrin activates the tyrosine kinase receptor muscle-sp...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80061-5
更新日期：1998-06-01 00:00:00
abstract：:Biological systems use internal circadian clocks to efficiently organize physiological and behavioral activity within the 24-hour time domain. In the absence of time cues, circadian periods vary slightly from 24 hours, but in nature, ambient light serves as the most salient synchronizer for these rhythms, fine-tuning ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2003.10.011
更新日期：2003-12-01 00:00:00
abstract：:The vestibular system provides an attractive model for understanding how changes in cellular and synaptic activity influence learning and memory in a quantifiable behavior, the vestibulo-ocular reflex. The vestibulo-ocular reflex produces eye movements that compensate for head motion; simple yet powerful forms of moto...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2006.06.012
更新日期：2006-08-01 00:00:00
abstract：:This review connects several lines of research to argue that hyperbolic geometry should be broadly applicable to neural circuits as well as other biological circuits. The reason for this is that networks that conform to hyperbolic geometry are maximally responsive to external and internal perturbations. These networks...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2019.07.008
更新日期：2019-10-01 00:00:00
abstract：:Ionotropic AMPA-type glutamate receptors and G-protein-coupled metabotropic GABAB receptors are key elements of neurotransmission whose cellular functions are determined by their protein constituents. Over the past couple of years unbiased proteomic approaches identified comprehensive sets of protein building blocks o...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.02.011
更新日期：2017-08-01 00:00:00
abstract：:During the past year,several model systems have been developed to identify cellular and biochemical events involved in neuronal cell death, to investigate the role of bcl-2 in cell survival, and to characterize the relationship between cell death and the cell cycle. ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(94)90036-1
更新日期：1994-02-01 00:00:00
abstract：:Neurotransmitters are released by Ca(2+)-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at a specialised presynaptic plasma membrane region, the active zone, where they are primed to a fusion competent state. The nature of this priming reaction has long been enigmatic. Recent evidence d...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(00)00105-7
更新日期：2000-06-01 00:00:00
abstract：:Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca(2+)-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2015.01.008
更新日期：2015-10-01 00:00:00
