The olfactory multigene family.


:A novel multigene family has been identified that is likely to encode odorant receptors on olfactory sensory neurons. Further studies on this gene family are likely to shed light on the molecular mechanisms underlying information coding in the mammalian olfactory system. This review is also published in Current Opinion in Genetics and Development 1992, 2:467-473.


Curr Opin Neurobiol


Buck LB




Has Abstract


1992-06-01 00:00:00












  • Neuromodulation of olfactory transformations.

    abstract::The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Linster C,Cleland TA

    更新日期:2016-10-01 00:00:00

  • Vagal sensory neurons and gut-brain signaling.

    abstract::Our understanding of the gut system has been revolutionized over the past decade, in particular regarding its role in immune control and psychological regulation. The vagus nerve is a crucial link between gut and brain, transmitting diverse gut-derived signals, and has been implicated in many gastrointestinal, neurolo...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Yu CD,Xu QJ,Chang RB

    更新日期:2020-06-01 00:00:00

  • Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism.

    abstract::Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cor...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Courchesne E

    更新日期:1997-04-01 00:00:00

  • The dynamic cytoskeleton: backbone of dendritic spine plasticity.

    abstract::Dendritic spines are small actin-rich protrusions on the surface of dendrites whose morphological and molecular plasticity play key roles in learning and memory. Both the form and function of spines are critically dependent on the actin cytoskeleton. However, new research, using electron microscopy and live-cell super...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Dent EW,Merriam EB,Hu X

    更新日期:2011-02-01 00:00:00

  • Efficiency turns the table on neural encoding, decoding and noise.

    abstract::Sensory neurons are usually described with an encoding model, for example, a function that predicts their response from the sensory stimulus using a receptive field (RF) or a tuning curve. However, central to theories of sensory processing is the notion of 'efficient coding'. We argue here that efficient coding implie...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Deneve S,Chalk M

    更新日期:2016-04-01 00:00:00

  • Bottom-up and top-down modulation of multisensory integration.

    abstract::Sensory perception in the real world requires proper integration of different modality inputs. Process of multisensory integration is not uniform. It varies from individual to individual and changes at different behavioral states of the animal. What factors affect multisensory integration? How does the mammalian brain...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Choi I,Lee JY,Lee SH

    更新日期:2018-10-01 00:00:00

  • Mechanisms of neurite repair.

    abstract::Upon receiving injury signals, neurons can activate various pathways to reduce harm, initiate neuroprotection, and repair damaged neurite without cell death. Here, we review recent progresses in the study of neurite repair focusing on neuronal cell-autonomous mechanisms, including new findings on ion channels that ser...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Liu HH,Jan YN

    更新日期:2020-08-01 00:00:00

  • Presynaptic ionotropic receptors.

    abstract::Recent studies have provided new insights into the role of presynaptic ligand-gated ion channels in modifying synaptic transmission. Along with a growing list of different types of presynaptic ionotropic receptors and the cell types that express them, there have been advances in characterizing the molecular components...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: McGehee DS,Role LW

    更新日期:1996-06-01 00:00:00

  • Development of motor behaviour.

    abstract::The development of motor behaviour depends on the differentiation of underlying circuitry. Recent work with the zebrafish brings the simple swimming behaviour of lower vertebrates and their embryos into focus as a suitable model to study the development of motor circuitry and its genetic control. Changes in connectivi...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Bate M

    更新日期:1999-12-01 00:00:00

  • The many facets of facial interactions in mammals.

    abstract::Facial interactions are prominent behaviors in primates. Primate facial signaling, which includes the expression of emotions, mimicking of facial movements, and gaze interactions, is visually dominated. Correspondingly, in primate brains an elaborate network of face processing areas exists within visual cortex. But ot...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Brecht M,Freiwald WA

    更新日期:2012-04-01 00:00:00

  • Genetic mosaic analysis in the nervous system.

    abstract::Genetic mosaic techniques provide a powerful tool for dissecting gene function in the intricate genetic networks that underlie the formation and function of nervous systems. For instance, it is possible to make individual cells or groups of cells homozygous for mutations of interest at specific points during an organi...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Zugates CT,Lee T

    更新日期:2004-10-01 00:00:00

  • Survival factors in retinal degenerations.

    abstract::Recent experiments on the retina have examined the effectiveness of various factors (e.g. growth factors, neurotrophins and cytokines) for enhancing survival and reducing injury of retinal neurons, such as photoreceptors and ganglion cells, whose death leads to blindness in degenerative retinal diseases. It has also b...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Steinberg RH

    更新日期:1994-08-01 00:00:00

  • Brain connectomes come of age.

    abstract::Databases of consistent, directed- and weighted inter-areal connectivity for mouse, macaque and marmoset monkeys have recently become available and begun to be used to build structural and dynamical models. A structural hierarchy can be defined based by laminar patterns of cortical connections. A large-scale dynamical...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Wang XJ,Pereira U,Rosa MG,Kennedy H

    更新日期:2020-12-01 00:00:00

  • Stimulating neurons with light.

    abstract::Recent technological advances have enabled the use of different optical methods to activate neurons, including 'caged' glutamate, photoactivation of genetically engineered cascades, and direct two-photon excitation. The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the te...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Callaway EM,Yuste R

    更新日期:2002-10-01 00:00:00

  • Peripheral pain mechanisms.

    abstract::Our understanding of the cellular and molecular bases of transduction of painful stimuli has burgeoned in the past year, mainly as a result of studies on isolated sensory neurones in culture. The ion channels underlying neuronal responses to noxious heat, to protons and to ATP have recently been characterized. The typ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Cesare P,McNaughton P

    更新日期:1997-08-01 00:00:00

  • Vnd/nkx, ind/gsh, and msh/msx: conserved regulators of dorsoventral neural patterning?

    abstract::Expression of vnd in ventral, ind in intermediate, and msh in dorsal columns of fly neurectoderm, and of homologous gene families in corresponding domains of vertebrate neurectoderm, suggests that elements of dorsoventral neural patterning have been evolutionarily conserved. However, upstream signaling pathways regula...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Cornell RA,Ohlen TV

    更新日期:2000-02-01 00:00:00

  • The growing family of myosin motors and their role in neurons and sensory cells.

    abstract::Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, r...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Hasson T,Mooseker MS

    更新日期:1997-10-01 00:00:00

  • Nanomaterials at the neural interface.

    abstract::Interfacing the nervous system with devices able to efficiently record or modulate the electrical activity of neuronal cells represents the underlying foundation of future theranostic applications in neurology and of current openings in neuroscience research. These devices, usually sensing cell activity via microelect...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Scaini D,Ballerini L

    更新日期:2018-06-01 00:00:00

  • Cyclic nucleotide gated channels as regulators of CNS development and plasticity.

    abstract::Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are p...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Zufall F,Shepherd GM,Barnstable CJ

    更新日期:1997-06-01 00:00:00

  • The gain in brain: novel imaging techniques and multiplexed proteomic imaging of brain tissue ultrastructure.

    abstract::The rapid accumulation of neuroproteomics data in recent years has prompted the emergence of novel antibody-based imaging methods that aim to understand the anatomical and functional context of the multitude of identified proteins. The pioneering field of ultrastructural multiplexed proteomic imaging now includes a nu...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Micheva KD,Bruchez MP

    更新日期:2012-02-01 00:00:00

  • Specificity and randomness: structure-function relationships in neural circuits.

    abstract::A fundamental but unsolved problem in neuroscience is how connections between neurons might underlie information processing in central circuits. Building wiring diagrams of neural networks may accelerate our understanding of how they compute. But even if we had wiring diagrams, it is critical to know what neurons in a...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Lee WC,Reid RC

    更新日期:2011-10-01 00:00:00

  • Regulation of cell adhesions and motility during initiation of neural crest migration.

    abstract::Accurate neural crest cell (NCC) migration requires tight control of cell adhesions, cytoskeletal dynamics and cell motility. Cadherins and RhoGTPases are critical molecular players that regulate adhesions and motility during initial delamination of NCCs from the neuroepithelium. Recent studies have revealed multiple ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Clay MR,Halloran MC

    更新日期:2011-02-01 00:00:00

  • Mechanisms of Müller glial cell morphogenesis.

    abstract::Müller Glia (MG), the radial glia cells of the retina, have spectacular morphologies subserving their enormous functional complexity. As early as 1892, the great neuroanatomist Santiago Ramon y Cajal studied the morphological development of MG, defining several steps in their morphogenesis [1,2]. However, the molecula...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: MacDonald RB,Charlton-Perkins M,Harris WA

    更新日期:2017-12-01 00:00:00

  • Observation-based learning for brain-machine interfaces.

    abstract::Canonically, 'mirror neurons' are cells in area F5 of the ventral premotor cortex that are active during both observation and execution of goal-directed movements. Recently, cells with similar properties have been observed in a number of other areas in the motor system, including the primary motor cortex. Mirror neuro...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Tkach D,Reimer J,Hatsopoulos NG

    更新日期:2008-12-01 00:00:00

  • Mechanisms of cerebellar learning suggested by eyelid conditioning.

    abstract::Classical eyelid conditioning has been used to great advantage in demonstrating that the cerebellum helps to improve movements through experience, and in identifying the underlying mechanisms. Results from recent studies support the hypotheses that learning occurs in both the cerebellar nucleus and cortex, and that th...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Medina JF,Nores WL,Ohyama T,Mauk MD

    更新日期:2000-12-01 00:00:00

  • Cerebral lateralization.

    abstract::Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Brown HD,Kosslyn SM

    更新日期:1993-04-01 00:00:00

  • Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.

    abstract::The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Ting JT,Feng G

    更新日期:2011-12-01 00:00:00

  • It takes a seasoned bird to be a good listener: communication between the sexes.

    abstract::Birds commonly use sound for communication between the sexes. In many songbird species, only males sing and there are pronounced sex differences in the neural song control circuits. By contrast, the auditory circuitry is largely similar in males and females. Both sexes learn to recognize vocalizations heard as juvenil...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Brenowitz EA,Remage-Healey L

    更新日期:2016-06-01 00:00:00

  • CREB and the formation of long-term memory.

    abstract::Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of th...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Yin JC,Tully T

    更新日期:1996-04-01 00:00:00

  • The temporal flexibility of attentional selection in the visual cortex.

    abstract::Visual attention operates by biasing competitive interactions between neural representations, favoring relevant over irrelevant visual inputs. Attention can enhance the processing of relevant information using location-based, feature-based or object-based selection mechanisms. Studies using event-related potential and...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审


    authors: Hopf JM,Schoenfeld MA,Heinze HJ

    更新日期:2005-04-01 00:00:00