Abstract：
:This review connects several lines of research to argue that hyperbolic geometry should be broadly applicable to neural circuits as well as other biological circuits. The reason for this is that networks that conform to hyperbolic geometry are maximally responsive to external and internal perturbations. These networks also allow for efficient communication under conditions where nodes are added or removed. We will argue that one of the signatures of hyperbolic geometry is the celebrated Zipf's law (also sometimes known as the Pareto distribution) that states that the probability to observe a given pattern is inversely related to its rank. Zipf's law is observed in a variety of biological systems - from protein sequences, neural networks to economics. These observations provide further evidence for the ubiquity of networks with an underlying hyperbolic metric structure. Recent studies in neuroscience specifically point to the relevance of a three-dimensional hyperbolic space for neural signaling. The three-dimensional hyperbolic space may confer additional robustness compared to other dimensions. We illustrate how the use of hyperbolic coordinates revealed a novel topographic organization within the olfactory system. The use of such coordinates may facilitate representation of relevant signals elsewhere in the brain.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Sharpee TOdoi
10.1016/j.conb.2019.07.008subject
Has Abstractpub_date
2019-10-01 00:00:00pages
101-104eissn
0959-4388issn
1873-6882pii
S0959-4388(18)30241-1journal_volume
58pub_type
杂志文章,评审abstract：:Perceptual and control systems are tasked with the challenge of accurately and efficiently estimating the dynamic states of objects in the environment. To properly account for uncertainty, it is necessary to maintain a dynamical belief state representation rather than a single state vector. In this review, canonical a...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.01.018
更新日期：2014-04-01 00:00:00
abstract：:Birds commonly use sound for communication between the sexes. In many songbird species, only males sing and there are pronounced sex differences in the neural song control circuits. By contrast, the auditory circuitry is largely similar in males and females. Both sexes learn to recognize vocalizations heard as juvenil...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.01.005
更新日期：2016-06-01 00:00:00
abstract：:How is an ant-equipped with a brain that barely exceeds the size of a pinhead-capable of achieving navigational marvels? Even though evidences suggest that navigation is a multimodal process, ants heavily depend on olfactory cues-of pheromonal and non-pheromonal nature-for foraging and orientation. Recent studies have...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2011.10.011
更新日期：2012-04-01 00:00:00
abstract：:Neural oscillations are ubiquitous in olfactory systems of mammals, insects and molluscs. Neurophysiological and computational investigations point to common mechanisms for gamma or odor associated oscillations across phyla (40-100Hz in mammals, 20-30Hz in insects, 0.5-1.5Hz in molluscs), engaging the reciprocal dendr...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.10.004
更新日期：2015-04-01 00:00:00
abstract：:Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are p...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(97)80070-0
更新日期：1997-06-01 00:00:00
abstract：:It is now 15 years since the discovery that N-methyl-d-aspartate receptor activity is required to maintain the refined topographic organization of retinotectal projections. Recent studies have identified additional components of the signaling pathways required for activity-dependent map formation and maintenance. Nitr...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(02)00295-7
更新日期：2002-02-01 00:00:00
abstract：:The aging peripheral nervous system (PNS) is prone to a number of disorders, including the development of neuropathies and increased regenerative failure. Although the basic mechanisms of the aging PNS are still rather murky, recent work has revealed that 'old' Schwann cells acquire a number of dysfunctions in mammals...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.10.022
更新日期：2017-12-01 00:00:00
abstract：:Nearly all studies of natural variation within clock genes involve the period (per) locus, which was originally isolated in the fruit-fly. Intra- and interspecific work on per has focused mostly on a region of Thr-Gly or Ser-Gly repeats, which show rapid length and sequence evolution. The functional implications of nu...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80096-2
更新日期：1998-10-01 00:00:00
abstract：:Visual perception is inherently statistical: brains exploit repeating features of natural scenes to disambiguate images that could, in principle, have many causes. A clear case for the relevance of statistical inference in vision is animal camouflage. Although visual scenes are each composed of unique arrangements of ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2019.10.010
更新日期：2020-02-01 00:00:00
abstract：:The adult mammalian neocortex, the major region of the cerebral cortex, is divided into functionally specialized areas, defined by distinct architecture and axonal connections. Extrinsic influences, such as thalamocortical input, and genetic regulation, intrinsic to the dorsal telencephalon, control the gradual emerge...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(02)00285-4
更新日期：2002-02-01 00:00:00
abstract：:Many constituents of Wnt signaling pathways are expressed in the developing and mature nervous systems. Recent work has shown that Wnt signaling controls initial formation of the neural plate and many subsequent patterning decisions in the embryonic nervous system, including formation of the neural crest. Wnt signalin...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(00)00100-8
更新日期：2000-06-01 00:00:00
abstract：:The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(02)00354-9
更新日期：2002-10-01 00:00:00
abstract：:Visual system development utilizes global and local cues to assemble a topographic map of the visual world, arranging synaptic connections into columns and layers. Recent genetic studies have provided new insights into the mechanisms that underlie these processes. In flies, a precise temporal sequence of neural differ...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2009.04.011
更新日期：2009-04-01 00:00:00
abstract：:The discovery of hair cell regeneration in the inner ear of birds provides new optimism that there may be a treatment for hearing and balance disorders. In this review we describe the process of hair cell regeneration in birds; including restoration of function, recovery of perception and what is currently known about...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(03)00018-7
更新日期：2003-02-01 00:00:00
abstract：:MicroRNAs (miRNAs) are a recently discovered, extensive class of small noncoding RNAs that act as post-transcriptional regulators of gene expression. miRNAs have been implicated in most aspects of animal development and in pathological processes such as cancer. In neurons, miRNAs are expressed at all stages of develop...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2009.05.015
更新日期：2009-04-01 00:00:00
abstract：:Work in cortically controlled neuroprosthetic systems has concentrated on decoding natural behaviors from neural activity, with the idea that if the behavior could be fully decoded it could be duplicated using an artificial system. Initial estimates from this approach suggested that a high-fidelity signal comprised of...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2004.10.013
更新日期：2004-12-01 00:00:00
abstract：:Identification of genetic mutations linked to familial neurodegenerative diseases have made it possible to generate useful transgenic animal models. Studies using these transgenic animals indicate that many familial neurodegenerative diseases, such as motor neuron disease, Alzheimer's disease, prion diseases and trinu...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(96)80099-7
更新日期：1996-10-01 00:00:00
abstract：:Fine balance between loss-of water and gain-of water is essential for maintaining body fluid homeostasis. The development of neural manipulation and mapping tools has opened up new avenues to dissect the neural circuits underlying body fluid regulation. Recent studies have identified several nodes in the brain that po...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2019.01.014
更新日期：2019-08-01 00:00:00
abstract：:The circuitry mediating the integration of reward perception and adaptive behavioral responses has been further refined. Recent developments indicate that the nucleus accumbens has a primary role in motivational circuitry, whereas afferents to the nucleus accumbens, in part, subserve distinct functions. Dopaminergic a...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(99)80031-2
更新日期：1999-04-01 00:00:00
abstract：:Echolocating bats exhibit accurate three-dimensional (3D) auditory localization to avoid obstacles and intercept prey. The bat achieves high spatial resolution through a biological sonar system. Key features of the bat's sonar system are (1) high frequency, directional echolocation signals; (2) high frequency hearing;...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2016.08.002
更新日期：2016-12-01 00:00:00
abstract：:Not only is the sense of smell of pivotal importance to most animals but also serves as a significant model system in biological research. In recent years, great strides in our understanding of how the olfactory system is organized and operates have been made. Instrumental in these efforts has been work performed in D...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2015.02.006
更新日期：2015-10-01 00:00:00
abstract：:Mammals have ∼1000 different olfactory receptor subtypes, each responding to a number of different odorants, and each odorant activating a number of different receptor subtypes. These molecular and anatomical underpinnings of olfaction imply a perceptual structure of very high dimensionality that relies on combinatori...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2013.12.010
更新日期：2014-04-01 00:00:00
abstract：:Circadian clocks organize neural processes, such as motor activities, into near 24-hour oscillations and adaptively synchronize these rhythms to the solar cycle. Recently, the first mammalian clock genes have been found. Unpredicted diversity in signaling pathways and clock-controlled gating of signals that modulate t...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(97)80138-9
更新日期：1997-12-01 00:00:00
abstract：:For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2017.03.006
更新日期：2017-08-01 00:00:00
abstract：:Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration. With 19 Wnts and 14 known receptors (10 Frizzl...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/j.conb.2014.05.005
更新日期：2014-08-01 00:00:00
abstract：:Heterogeneity among progenitor cells in the vertebrate nervous system has been documented with increasing frequency over the past few years. It has become clear that differences in progenitor cells help to determine when and how they respond to environmental signals. More recent studies have begun to elucidate the mol...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(98)80006-8
更新日期：1998-02-01 00:00:00
abstract：:Neuroscience research has become increasingly reliant upon quantitative and computational data analysis and modeling techniques. However, the vast majority of neuroscientists are still trained within the traditional biology curriculum, in which computational and quantitative approaches beyond elementary statistics may...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章
doi：10.1016/j.conb.2017.06.007
更新日期：2017-10-01 00:00:00
abstract：:Neurotransmitters are released by Ca(2+)-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at a specialised presynaptic plasma membrane region, the active zone, where they are primed to a fusion competent state. The nature of this priming reaction has long been enigmatic. Recent evidence d...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(00)00105-7
更新日期：2000-06-01 00:00:00
abstract：:The hippocampal formation has a unique and highly distributed network of intrinsic connections. What are the principles of organization that govern information flow through this system? The notion that information processing in the hippocampal formation is segregated in autonomous chips or lamellae appears to be incon...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/0959-4388(93)90214-j
更新日期：1993-04-01 00:00:00
abstract：:Ambiguous figures that may take on the appearance of two or more distinct forms have fascinated philosophers and psychologists for generations. Recently, several laboratories have studied the neuronal basis of perceptual appearance at the level of single neurons in the cerebral cortex. Experiments that integrate neuro...
journal_title：Current opinion in neurobiology
pub_type： 杂志文章,评审
doi：10.1016/s0959-4388(03)00099-0
更新日期：2003-08-01 00:00:00
