Abstract:
:Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca(2+)-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically activated by physical effects of PIP2 depletion on the membrane, in combination with protons released by PLC. We also review molecularly explicit models indicating how Ca(2+)-dependent positive and negative feedback along with the ultracompartmentalization provided by the microvillar design can account for the ability of fly photoreceptors to respond to single photons 10-100× more rapidly than vertebrate rods, yet still signal under full sunlight.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Hardie RC,Juusola Mdoi
10.1016/j.conb.2015.01.008subject
Has Abstractpub_date
2015-10-01 00:00:00pages
37-45eissn
0959-4388issn
1873-6882pii
S0959-4388(15)00017-3journal_volume
34pub_type
杂志文章,评审abstract::A number of laboratories have recently refined descriptions of temporal response properties, from the auditory periphery to the midbrain. At many levels of the auditory pathway, the role of inhibition in temporal coding of complex sounds is being explored. In addition, quantitative relationships between physiology and...
journal_title:Current opinion in neurobiology
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abstract::Selective transport of transmembrane proteins to different intracellular compartments often involves the recognition of sorting signals in the cytosolic domains of the proteins by components of membrane coats. Some of these coats have as their key components a family of heterotetrameric adaptor protein (AP) complexes ...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::Trans-synaptic interactions organize the multiple steps of synaptic development and are critical to generate fully functional neuronal circuits. While trans-synaptic interactions are primarily mediated by cell adhesion molecules (CAMs), some directly involve ionotropic glutamate receptors (iGluRs). Here, we review the...
journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::This article reviews recent evidence suggesting that endogenous ciliary neurotrophic factor may be involved in neural responses to injury, and discusses the possibility that ciliary neurotrophic factor could have therapeutic applications in a clinical setting. The functional relevance of ciliary neurotrophic factor in...
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journal_title:Current opinion in neurobiology
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abstract::Biology provides examples of efficient machines which greatly outperform conventional technology. Designers in neuromorphic engineering aim to construct electronic systems with the same efficient style of computation. This task requires a melding of novel engineering principles with knowledge gleaned from neuroscience...
journal_title:Current opinion in neurobiology
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abstract::Comparative studies over the past year have revealed two new insights into the role of neuropeptides in the evolution of social behaviors. First, across vertebrate taxa, certain neuropeptide effects appear to be gender-specific. Second, species variations in receptor gene structure can alter neuropeptide receptor dist...
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
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abstract::Despite considerable skepticism, researchers have found that the patterns of muscle activation that control feeding behaviors of lower vertebrates have been surprisingly conserved during evolution. This tendency for conservation among taxa appears in the face of marked flexibility of motor patterns within individuals....
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