Abstract:
:Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are not only necessary for normal slow-wave-sleep (SWS) but that their selective activation is sufficient to induce SWS in behaving animals. In this review we discuss early experimental findings that inspired the hypothesis that the caudal brainstem contained SWS-promoting circuitry. We then describe the discovery of the SWS-promoting PZGABA and discuss future experimental priorities.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Anaclet C,Fuller PMdoi
10.1016/j.conb.2017.04.004subject
Has Abstractpub_date
2017-06-01 00:00:00pages
139-143eissn
0959-4388issn
1873-6882pii
S0959-4388(16)30243-4journal_volume
44pub_type
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