Abstract:
:In the mammalian cortex, the classic view assumes that the output information of a neuron is encoded in rather stereotyped action potentials, which provide an all-or-none or digital way of communication between cell body and axonal boutons. A role for subthreshold signal propagation within cortical axons has largely been ignored. Recent achievements of direct recordings from axonal structures in the hippocampus and neocortex extended the classic view by the observation that subthreshold-graded signals propagate down the axon over distances of up to 1 mm. At certain synapses, these analog axonal signals modulate action-potential-dependent transmitter release, thereby enabling a hybrid code of information transmission in local cortical circuits.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Alle H,Geiger JRdoi
10.1016/j.conb.2008.08.006subject
Has Abstractpub_date
2008-06-01 00:00:00pages
314-20issue
3eissn
0959-4388issn
1873-6882pii
S0959-4388(08)00079-2journal_volume
18pub_type
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