Abstract:
:The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glutamate in the synaptic cleft does not attain levels previously suggested. In contrast, recordings from glial cells and studies of extrasynaptic receptor activation indicate that significant quantities of glutamate escape from the cleft following exocytosis. Determining the amount of glutamate efflux from the synaptic cleft and the distance it diffuses is critical to issues of synaptic specificity and the induction of synaptic plasticity.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Bergles DE,Diamond JS,Jahr CEdoi
10.1016/s0959-4388(99)80043-9subject
Has Abstractpub_date
1999-06-01 00:00:00pages
293-8issue
3eissn
0959-4388issn
1873-6882pii
nb9304journal_volume
9pub_type
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