Functional flexibility in cortical circuits.

abstract：:Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for...

journal_title：Current opinion in neurobiology

authors： Herstel LJ,Wierenga CJ

更新日期：2020-08-24 00:00:00

abstract：:Recent findings suggest that cerebral laterality will not be understood in terms of simple dichotomies, such as the idea that the left hemisphere is analytic and the right holistic. Rather, hemisphere differences can be better explained in terms of relatively specific principles that extend over limited domains. For v...

journal_title：Current opinion in neurobiology

authors： Brown HD,Kosslyn SM

更新日期：1993-04-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:Neuroeconomics is an interdisciplinary field, crossing boundaries between Economics, Psychology, and Neuroscience. Its original program was to provide a test for a large number of competitive theories of decision making. It has in part realized this program, and we review the main findings here. But its results are al...

journal_title：Current opinion in neurobiology

authors： Rustichini A

更新日期：2009-12-01 00:00:00

abstract：:AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent sub...

journal_title：Current opinion in neurobiology

authors： Jacobi E,von Engelhardt J

更新日期：2017-08-01 00:00:00

abstract：:Neuropeptide Y is an important regulator of energy intake and expenditure. The central portion of this regulatory system appears to reside in the arcuate nucleus/paraventricular nucleus of the hypothalamus. The effects of neuropeptide Y on energy metabolism include increased food intake, decreased thermogenesis and in...

journal_title：Current opinion in neurobiology

authors： Billington CJ,Levine AS

更新日期：1992-12-01 00:00:00

abstract：:Sensory perception in the real world requires proper integration of different modality inputs. Process of multisensory integration is not uniform. It varies from individual to individual and changes at different behavioral states of the animal. What factors affect multisensory integration? How does the mammalian brain...

journal_title：Current opinion in neurobiology

authors： Choi I,Lee JY,Lee SH

更新日期：2018-10-01 00:00:00

abstract：:Vocalizations transmit information to social partners, and mice use these signals to exchange information during courtship. Ultrasonic vocalizations from adult males are tightly associated with their interactions with females, and vary as a function of male quality. Work in the last decade has established that the spe...

journal_title：Current opinion in neurobiology

authors： Egnor SR,Seagraves KM

更新日期：2016-06-01 00:00:00

abstract：:The recent cloning of the gamma-aminobutyric acid and norepinephrine Na(+)-dependent neurotransmitter transporters has led to new approaches for understanding the structure and function of these important synaptic proteins and provides a conceptual model in which to consider recent advances in the physiology, pharmaco...

journal_title：Current opinion in neurobiology

authors： Amara SG,Pacholczyk T

更新日期：1991-06-01 00:00:00

abstract：:Drosophila melanogaster has historically been the premier model system for understanding the molecular and genetic bases of complex behaviors. In the last decade technical advances, in the form of new genetic tools and electrophysiological and optical methods, have allowed investigators to begin to dissect the neurona...

journal_title：Current opinion in neurobiology

authors： Griffith LC

更新日期：2012-08-01 00:00:00

abstract：:Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cor...

journal_title：Current opinion in neurobiology

authors： Courchesne E

更新日期：1997-04-01 00:00:00

abstract：:In the past five years, the surrounding of the brain, that is the meninges (singular meninx) have evolved from being a physical barrier that protects the brain parenchyma to becoming a central player for both the maintenance of normal brain function and the modulation of neurological disorders. Indeed, the meninges ar...

journal_title：Current opinion in neurobiology

authors： Frederick N,Louveau A

更新日期：2020-06-01 00:00:00

abstract：:During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there ...

journal_title：Current opinion in neurobiology

authors： Reiner O,Parichha A,Sapir T

更新日期：2020-10-15 00:00:00

abstract：:Cyclic AMP response element binding protein (CREB)-responsive transcription plays a central role in the formation of long-term memory in Drosophila, Aplysia and mice. Agents that disrupt the activity of CREB specifically block the formation of long-term memory, whereas agents that increase the amount or activity of th...

journal_title：Current opinion in neurobiology

authors： Yin JC,Tully T

更新日期：1996-04-01 00:00:00

abstract：:Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...

journal_title：Current opinion in neurobiology

authors： Mišić B,Sporns O

更新日期：2016-10-01 00:00:00

abstract：:The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...

journal_title：Current opinion in neurobiology

authors： Backman S,Stambolic V,Mak T

更新日期：2002-10-01 00:00:00

abstract：:Parenting is essential for survival and wellbeing in many species. Since it can be performed with little prior experience and entails considerable sacrifices without immediate benefits for the caregiver, this behavior is likely orchestrated by evolutionarily shaped, hard-wired neural circuits. At the same time, experi...

journal_title：Current opinion in neurobiology

authors： Kohl J

更新日期：2020-02-01 00:00:00

abstract：:Associative fear learning in the basolateral amygdala (BLA) is crucial for an animal's survival upon environmental threats. BLA neurons are defined on the basis of their projection target, genetic markers, and associated function. BLA principal neuron responses to threat signaling stimuli are potentiated upon associat...

journal_title：Current opinion in neurobiology

authors： Gründemann J,Lüthi A

更新日期：2015-12-01 00:00:00

abstract：:The use of gene transfer techniques to express novel proteins within different cellular populations has provided insights into the function and plasticity of the brain. Recently, this technique has been successfully used to explore physiological processes within the CNS and to intervene in neurodegenerative disease an...

journal_title：Current opinion in neurobiology

authors： Fisher LJ,Ray J

更新日期：1994-10-01 00:00:00

abstract：:Neurons utilize mRNA transport and local translation as a means to influence development and plasticity. The molecular mechanisms for this mRNA sorting involve the recognition of cis-acting sequences by distinct mRNA binding proteins that have a dual role, acting in both mRNA transport and translational regulation. Ot...

journal_title：Current opinion in neurobiology

authors： Bassell GJ,Kelic S

更新日期：2004-10-01 00:00:00

abstract：:Over the past year, evidence has accrued that adult CNS stem cells are a widespread progenitor cell type. These cells may normally replace neurons and/or glia in the adult brain and spinal cord. Advances have been made in understanding the signals that regulate stem cell proliferation and differentiation. A deeper und...

journal_title：Current opinion in neurobiology

authors： Temple S,Alvarez-Buylla A

更新日期：1999-02-01 00:00:00

abstract：:Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia (FTD). Mutations of these genes lea...

journal_title：Current opinion in neurobiology

authors： Wang C,Telpoukhovskaia MA,Bahr BA,Chen X,Gan L

更新日期：2018-02-01 00:00:00

abstract：:The development of increasingly sophisticated methods for recording and manipulating neural activity is revolutionizing neuroscience. By probing how activity patterns in different types of neurons and circuits contribute to behavior, these tools can help inform mechanistic models of brain function and explain the role...

journal_title：Current opinion in neurobiology

authors： Wolff SB,Ölveczky BP

更新日期：2018-04-01 00:00:00

abstract：:Ca2+ entry into neurons is one of the major effectors of stimulus-induced physiological change. Ca2+ can enter neurons through a number of different voltage-gated and ligand-gated channels. Depending on the route of entry, Ca2+ stimulates distinct intracellular signaling pathways, which activate different sets of gene...

journal_title：Current opinion in neurobiology

authors： Gallin WJ,Greenberg ME

更新日期：1995-06-01 00:00:00

abstract：:The large capacity of episodic memory is thought to be supported by the emergence of distinct hippocampal cell assemblies for unrelated memories, such that interference is minimized. In large-scale population recordings, the orthogonal nature of hippocampal representations across environments is evident in the complet...

journal_title：Current opinion in neurobiology

authors： Sasaki T,Leutgeb S,Leutgeb JK

更新日期：2015-06-01 00:00:00

abstract：:Neuroscientists spent decades debating whether synaptic plasticity was presynaptically or postsynaptically expressed. It was eventually concluded that plasticity depends on many factors, including cell type. More recently, it has become increasingly clear that plasticity is regulated at an even finer grained level; it...

journal_title：Current opinion in neurobiology

authors： Larsen RS,Sjöström PJ

更新日期：2015-12-01 00:00:00

abstract：:Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein ...

journal_title：Current opinion in neurobiology

authors： Lewis DA

更新日期：2014-06-01 00:00:00

abstract：:Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic st...

journal_title：Current opinion in neurobiology

authors： Blanquie O,Bradke F

更新日期：2018-08-01 00:00:00

abstract：:Increasingly systematic approaches to quantifying receptive fields in primary visual cortex, combined with inspired ideas about functional circuitry, non-linearities, and visual stimuli, are bringing new interest to classical problems. This includes the distinction and hierarchy between simple and complex cells, the m...

journal_title：Current opinion in neurobiology

authors： Bair W

更新日期：2005-08-01 00:00:00

abstract：:The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

journal_title：Current opinion in neurobiology

authors： Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

更新日期：2020-06-01 00:00:00