Abstract:
:Schizophrenia is a disorder of cognitive neurodevelopment. At least some of the core cognitive deficits of the illness appear to be the product of impaired gamma frequency oscillations which depend, in part, on the inhibitory actions of a subpopulation of cortical GABA neurons that express the calcium binding protein parvalbumin (PV). Recent studies have revealed new facets of the development of PV neurons in primate neocortex and of the nature of their molecular alterations in individuals with schizophrenia. Other recent studies in model systems provide insight into how these alterations may arise in the course of cortical circuitry development.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Lewis DAdoi
10.1016/j.conb.2013.11.003subject
Has Abstractpub_date
2014-06-01 00:00:00pages
22-6eissn
0959-4388issn
1873-6882pii
S0959-4388(13)00213-4journal_volume
26pub_type
杂志文章,评审abstract::Our understanding of the cellular and molecular bases of transduction of painful stimuli has burgeoned in the past year, mainly as a result of studies on isolated sensory neurones in culture. The ion channels underlying neuronal responses to noxious heat, to protons and to ATP have recently been characterized. The typ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(97)80028-1
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abstract::The cadherin superfamily is a large (now more than 100 proteins) protein family originally identified as cell adhesion molecules. Each cadherin shows distinct expression patterns in the nervous system, and their expressions are both spatially and temporally regulated and diverse among different species. Mounting evide...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.06.001
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abstract::Associative fear learning in the basolateral amygdala (BLA) is crucial for an animal's survival upon environmental threats. BLA neurons are defined on the basis of their projection target, genetic markers, and associated function. BLA principal neuron responses to threat signaling stimuli are potentiated upon associat...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Work during the past year has revealed increasing diversity and complexity of sensory inputs that trigger behavior, and correspondingly wide-ranging adaptations of sensory receptors and receptor organs. Many of these have been discovered by taking careful account of the animal in its natural habitat. Studies on centra...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(93)90175-x
更新日期:1993-12-01 00:00:00
abstract::Cell fate in the cephalic neural primordium is controlled by an organizer located at the midbrain-hindbrain boundary. Studies in chick, mouse and zebrafish converge to show that mutually repressive interactions between homeodomain transcription factors of the Otx and Gbx class position this organizer in the neural pri...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00171-9
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abstract::Of the few animal groups that learn their vocalizations, songbirds are uniquely amenable to molecular, physiological, and behavioral analyses of the neural features responsible for vocal learning. In order to communicate effectively as an adult, a young songbird recognizes and memorizes a model of his species-specific...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00242-7
更新日期:2001-08-01 00:00:00
abstract::One of the seminal discoveries in developmental neuroscience is that altering visual experience through monocular deprivation can alter both the physiological and the anatomical representation of the two eyes, called ocular dominance columns, in primary visual cortex. This rearrangement is restricted to a critical per...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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更新日期:2018-10-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2009.12.006
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.08.002
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(91)90068-i
更新日期:1991-10-01 00:00:00
abstract::Connections and interactions among distributed brain areas are increasingly recognized as the basis for cognitive operations and a diverse repertoire of behaviors. Analytic advances have allowed for brain connectivity to be represented and quantified at multiple levels: from single connections to communities and netwo...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.05.003
更新日期:2016-10-01 00:00:00
abstract::The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.07.006
更新日期:2016-10-01 00:00:00
abstract::Mosquitoes use their sense of smell to find hosts, nectar, and oviposition sites, and to avoid repellents. A small number of mosquito species are adapted to feed on humans and have a major impact on public health by transmitting diseases such as malaria, dengue and filariasis. The application of odorants for behaviora...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.06.014
更新日期:2015-10-01 00:00:00
abstract::Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals t...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.11.008
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abstract::Recent results have shown the possibility of both reconstructing connectomes of small but biologically interesting circuits and extracting from these connectomes insights into their function. However, these reconstructions were heroic proof-of-concept experiments, requiring person-months of effort per neuron reconstru...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.01.019
更新日期:2014-04-01 00:00:00
abstract::The heated debate over the level of postsynaptic receptor occupancy by transmitter has not been extinguished - indeed, new evidence is fanning the flames. Recent experiments using two-photon microscopy suggest that the concentration of glutamate in the synaptic cleft does not attain levels previously suggested. In con...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(99)80043-9
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journal_title:Current opinion in neurobiology
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.03.009
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abstract::MicroRNAs (miRNAs) are a recently discovered, extensive class of small noncoding RNAs that act as post-transcriptional regulators of gene expression. miRNAs have been implicated in most aspects of animal development and in pathological processes such as cancer. In neurons, miRNAs are expressed at all stages of develop...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2009.05.015
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Feeding history and the presence of food dramatically alter chemosensory behaviors. Recent results indicate that internal nutritional state can gate peripheral gustatory and olfactory sensory responses to affect behavior. Focusing primarily on recent work in C. elegans and Drosophila, I describe the neuromodulatory me...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
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abstract::Functional magnetic resonance imaging (fMRI) is used widely to determine the spatial layout of brain activation associated with specific cognitive tasks at a spatial scale of millimeters. Recent methodological improvements have made it possible to determine the latency and temporal structure of the activation at a tem...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00044-8
更新日期:2003-04-01 00:00:00
abstract::Animals respond to sensory cues emitted by their conspecifics by initiating a repertoire of sex-specific social behaviors, such as mating, fighting, and parental care. These behavioral responses are thought to be largely driven by genetically pre-programmed circuits. However, they can also vary significantly according...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.07.005
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abstract::AMPA receptors (AMPARs) mediate the majority of fast excitatory synaptic transmission in the brain. Dynamic changes in neuronal synaptic efficacy, termed synaptic plasticity, are thought to underlie information coding and storage in learning and memory. One major mechanism that regulates synaptic strength involves the...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.12.006
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abstract::The visual system is tasked with extracting stimulus content (e.g. the identity of an object) from the spatiotemporal light pattern falling on the retina. However, visual information can be ambiguous with regard to content (e.g. an object when viewed from far away), requiring the system to also consider contextual inf...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.04.013
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.10.003
更新日期:2008-10-01 00:00:00
abstract::During the past few decades, we have witnessed an impressive gain in the knowledge regarding the basic mechanisms underlying human neuronal migration disorders by the usage of mouse models. Nevertheless, despite the remarkable conservation both in the genetic encoded information and the developmental processes, there ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2020.09.005
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