Meningeal lymphatics, immunity and neuroinflammation.

Abstract:

:In the past five years, the surrounding of the brain, that is the meninges (singular meninx) have evolved from being a physical barrier that protects the brain parenchyma to becoming a central player for both the maintenance of normal brain function and the modulation of neurological disorders. Indeed, the meninges are an immunologically active compartment that communicates with the periphery via the (re)discovered meningeal lymphatic system. From its ties to both the periphery and the central nervous system, the meninges are becoming a prevalent organ to understand and modulate brain homeostasis. Here we will focus on current advances in our understanding of the meningeal compartment with an emphasis on the meningeal lymphatic network as a key regulator.

journal_name

Curr Opin Neurobiol

authors

Frederick N,Louveau A

doi

10.1016/j.conb.2019.11.010

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

41-47

eissn

0959-4388

issn

1873-6882

pii

S0959-4388(19)30116-3

journal_volume

62

pub_type

杂志文章,评审
  • The case for and against muscle synergies.

    abstract::A long standing goal in motor control is to determine the fundamental output controlled by the CNS: does the CNS control the activation of individual motor units, individual muscles, groups of muscles, kinematic or dynamic features of movement, or does it simply care about accomplishing a task? Of course, the output c...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2009.09.002

    authors: Tresch MC,Jarc A

    更新日期:2009-12-01 00:00:00

  • The evolution of language from social cognition.

    abstract::Despite their differences, human language and the vocal communication of nonhuman primates share many features. Both constitute a form of joint action, rely on similar neural mechanisms, and involve discrete, combinatorial cognition. These shared features suggest that during evolution the ancestors of modern primates ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2014.04.003

    authors: Seyfarth RM,Cheney DL

    更新日期:2014-10-01 00:00:00

  • Ambiguity and invariance: two fundamental challenges for visual processing.

    abstract::The visual system is tasked with extracting stimulus content (e.g. the identity of an object) from the spatiotemporal light pattern falling on the retina. However, visual information can be ambiguous with regard to content (e.g. an object when viewed from far away), requiring the system to also consider contextual inf...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2010.04.013

    authors: Rust NC,Stocker AA

    更新日期:2010-06-01 00:00:00

  • Orexin deficiency and narcolepsy.

    abstract::Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2013.04.007

    authors: Sakurai T

    更新日期:2013-10-01 00:00:00

  • Brainstem regulation of slow-wave-sleep.

    abstract::Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2017.04.004

    authors: Anaclet C,Fuller PM

    更新日期:2017-06-01 00:00:00

  • Ontogenetic rules and constraints of vestibulo-ocular reflex development.

    abstract::Vestibulo-ocular reflexes (VOR) assist retinal image stabilization during vertebrate locomotion thereby ensuring accurate visual perception. The importance of this motor behavior for animal survival requires that the underlying circuitry and all individual components are fully developed and functional as soon as post-...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2010.06.003

    authors: Straka H

    更新日期:2010-12-01 00:00:00

  • Neuromodulation of central pattern generators in invertebrates and vertebrates.

    abstract::Central pattern generators are subject to extensive modulation that generates flexibility in the rhythmic outputs of these neural networks. The effects of neuromodulators interact with one another, and modulatory neurons are themselves often subject to modulation, enabling both higher order control and indirect intera...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2006.10.007

    authors: Dickinson PS

    更新日期:2006-12-01 00:00:00

  • Insights from the application of computational neuroimaging to social neuroscience.

    abstract::A recent approach in social neuroscience has been the application of formal computational models for a particular social-cognitive process to neuroimaging data. Here we review preliminary findings from this nascent subfield, focusing on observational learning and strategic interactions. We present evidence consistent ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2013.02.007

    authors: Dunne S,O'Doherty JP

    更新日期:2013-06-01 00:00:00

  • Optogenetic stimulation of the auditory pathway for research and future prosthetics.

    abstract::Sound is encoded by spiral ganglion neurons (SGNs) in the hearing organ, the cochlea, with great temporal, spectral and intensity resolution. When hearing fails, electric stimulation by implanted prostheses can partially restore hearing. Optical stimulation promises a fundamental advance of hearing restoration over el...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2015.01.004

    authors: Moser T

    更新日期:2015-10-01 00:00:00

  • Viral vectors for modulating gene expression in neurons.

    abstract::The inability to reliably express foreign proteins in postmitotic neurons has hampered numerous studies in the field of neurobiology. Within the past several years, a number of viral vectors that overcome this problem under controlled conditions in vitro have been developed. In particular, recombinant adenoviruses hav...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(96)80088-2

    authors: Slack RS,Miller FD

    更新日期:1996-10-01 00:00:00

  • The microbiome-gut-brain axis in acute and chronic brain diseases.

    abstract::The gut microbiome - the largest reservoir of microorganisms of the human body - is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer's disease and Parkinson's disease. The growing knowledge on mediators and triggered pathways has advanced our under...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2019.11.009

    authors: Benakis C,Martin-Gallausiaux C,Trezzi JP,Melton P,Liesz A,Wilmes P

    更新日期:2020-04-01 00:00:00

  • Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism.

    abstract::Recent autopsy and/or quantitative magnetic resonance imaging studies of autistic patients have identified agenesis of the superior olive, dysgenesis of the facial nucleus, reduced numbers of Purkinje neurons, hypoplasia of the brainstem and posterior cerebellum, and increased neuron-packing density of the medial, cor...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(97)80016-5

    authors: Courchesne E

    更新日期:1997-04-01 00:00:00

  • Optogenetics and thermogenetics: technologies for controlling the activity of targeted cells within intact neural circuits.

    abstract::In recent years, interest has grown in the ability to manipulate, in a temporally precise fashion, the electrical activity of specific neurons embedded within densely wired brain circuits, in order to reveal how specific neurons subserve behaviors and neural computations, and to open up new horizons on the clinical tr...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2011.10.023

    authors: Bernstein JG,Garrity PA,Boyden ES

    更新日期:2012-02-01 00:00:00

  • The cell biology of synaptic inhibition in health and disease.

    abstract::Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2010.06.001

    authors: Smith KR,Kittler JT

    更新日期:2010-10-01 00:00:00

  • Neural mechanisms of behavior.

    abstract::Work during the past year has revealed increasing diversity and complexity of sensory inputs that trigger behavior, and correspondingly wide-ranging adaptations of sensory receptors and receptor organs. Many of these have been discovered by taking careful account of the animal in its natural habitat. Studies on centra...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/0959-4388(93)90175-x

    authors: Camhi JM

    更新日期:1993-12-01 00:00:00

  • Visual cortical networks: of mice and men.

    abstract::The visual cortical network consists of a number of specialized areas that are connected in a highly structured way. Understanding the function of this network is a milestone goal of visual neuroscience. This goal is pursued at different levels of description, including large-scale neuroanatomical as well as molecular...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2013.01.019

    authors: Katzner S,Weigelt S

    更新日期:2013-04-01 00:00:00

  • Food, microbes, sex and old age: on the plasticity of gastrointestinal innervation.

    abstract::The gastrointestinal tract is innervated by its own enteric nervous system and by extrinsic neurons that connect it with the central nervous system. Innervation allows the gastrointestinal tract to sense and respond to diverse stimuli, adjusting motility and secretion, but also affecting our physiology, behaviour and ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2019.12.004

    authors: Ameku T,Beckwith H,Blackie L,Miguel-Aliaga I

    更新日期:2020-06-01 00:00:00

  • Neuromodulation of olfactory transformations.

    abstract::The olfactory bulb and piriform cortex are the best studied structures of the mammalian olfactory system and are heavily innervated by extrinsic neuromodulatory inputs. The state-dependent release of acetylcholine, norepinephrine, serotonin, and other neuromodulators into these olfactory structures alters a constellat...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2016.07.006

    authors: Linster C,Cleland TA

    更新日期:2016-10-01 00:00:00

  • Contextual signals in visual cortex.

    abstract::Vision is an active process. What we perceive strongly depends on our actions, intentions and expectations. During visual processing, these internal signals therefore need to be integrated with the visual information from the retina. The mechanisms of how this is achieved by the visual system are still poorly understo...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2018.05.003

    authors: Khan AG,Hofer SB

    更新日期:2018-10-01 00:00:00

  • Olfaction in Drosophila.

    abstract::The fruit fly, Drosophila melanogaster, is equipped with a sophisticated olfactory sensory system that permits it to recognize and discriminate hundreds of discrete odorants. The perception of these odorants is essential for the animal to identify relevant food sources and suitable sites for egg-laying. Advances in th...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(00)00111-2

    authors: Vosshall LB

    更新日期:2000-08-01 00:00:00

  • Axon guidance and injury-lessons from Wnts and Wnt signaling.

    abstract::Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration. With 19 Wnts and 14 known receptors (10 Frizzl...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2014.05.005

    authors: Onishi K,Hollis E,Zou Y

    更新日期:2014-08-01 00:00:00

  • Motor and cognitive functions of the ventral premotor cortex.

    abstract::Recent data show that the ventral premotor cortex in both humans and monkeys has motor and cognitive functions. The cognitive functions include space perception, action understanding and imitation. The data also show a clear functional homology between monkey area F5 and human area 44. Preliminary evidence suggests th...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(02)00308-2

    authors: Rizzolatti G,Fogassi L,Gallese V

    更新日期:2002-04-01 00:00:00

  • Music perception, pitch, and the auditory system.

    abstract::The perception of music depends on many culture-specific factors, but is also constrained by properties of the auditory system. This has been best characterized for those aspects of music that involve pitch. Pitch sequences are heard in terms of relative as well as absolute pitch. Pitch combinations give rise to emerg...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2008.09.005

    authors: McDermott JH,Oxenham AJ

    更新日期:2008-08-01 00:00:00

  • Functional understanding facilitates learning about tools in human children.

    abstract::Human children benefit from a possibly unique set of adaptations facilitating the acquisition of knowledge about material culture. They represent artifacts (human-made objects) as tools with specific functions and seek for functional information about novel objects. Even young infants pay attention to functionally rel...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2009.05.003

    authors: Hernik M,Csibra G

    更新日期:2009-02-01 00:00:00

  • How social experiences influence the brain.

    abstract::Social experiences throughout life influence gene expression and behavior, however, early in development these influences have a particularly profound effect. In mammals, mother-infant interactions are the primary source of social stimulation and result in long-term changes in offspring phenotype. This has previously ...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2005.10.001

    authors: Champagne FA,Curley JP

    更新日期:2005-12-01 00:00:00

  • Development of the zebrafish lateral line.

    abstract::The lateral line system is simple (comprising six cell types), its sense organs form according to a defined and reproducible pattern, and its neurons are easily visualized. In the zebrafish, these advantages can be combined with a wealth of genetic tools, making this system ideally suited to a combined molecular, cell...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2004.01.012

    authors: Ghysen A,Dambly-Chaudière C

    更新日期:2004-02-01 00:00:00

  • RNA trafficking in myelinating cells.

    abstract::In the past year, several key molecular components of the RNA trafficking pathway in myelinating cells have been identified: distinct cis-acting elements for RNA transport and localization have been characterized in myelin basic protein mRNA; hnRNP A2 has been identified as a trans-acting factor in oligodendrocytes th...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(98)80088-3

    authors: Carson JH,Kwon S,Barbarese E

    更新日期:1998-10-01 00:00:00

  • Endocannabinoid-mediated retrograde modulation of synaptic transmission.

    abstract::One of the two major endocannabinoids, 2-arachidonoylglycerol (2-AG), serves as a retrograde messenger at various types of synapses throughout the brain. Upon postsynaptic activation, 2-AG is released immediately after de novo synthesis, activates presynaptic CB1 cannabinoid receptors, and transiently suppresses neuro...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.conb.2014.03.017

    authors: Ohno-Shosaku T,Kano M

    更新日期:2014-12-01 00:00:00

  • Stimulating neurons with light.

    abstract::Recent technological advances have enabled the use of different optical methods to activate neurons, including 'caged' glutamate, photoactivation of genetically engineered cascades, and direct two-photon excitation. The ability to use light as a stimulation tool provides, in principle, a non-invasive method for the te...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(02)00364-1

    authors: Callaway EM,Yuste R

    更新日期:2002-10-01 00:00:00

  • Learning to communicate.

    abstract::Of the few animal groups that learn their vocalizations, songbirds are uniquely amenable to molecular, physiological, and behavioral analyses of the neural features responsible for vocal learning. In order to communicate effectively as an adult, a young songbird recognizes and memorizes a model of his species-specific...

    journal_title:Current opinion in neurobiology

    pub_type: 杂志文章,评审

    doi:10.1016/s0959-4388(00)00242-7

    authors: White SA

    更新日期:2001-08-01 00:00:00