Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics.

Abstract:

:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive-repetitive behaviors.

journal_name

Curr Opin Neurobiol

authors

Ting JT,Feng G

doi

10.1016/j.conb.2011.04.010

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

842-8

issue

6

eissn

0959-4388

issn

1873-6882

pii

S0959-4388(11)00068-7

journal_volume

21

pub_type

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