Abstract:
:The precise causal factors for obsessive-compulsive disorder (OCD) are not known, although, decades of research have honed in on the cortico-striatal-thalamo-cortical (CSTC) circuitry in the brain as a critical pathway involved in obsessions and the intimately linked compulsive-repetitive behaviors. Recent progress in human and mouse genetics have led to the identification of novel candidate susceptibility genes, which in turn have facilitated a more focused approach to unraveling the nature of circuitry dysfunction in OCD. The ability to perform invasive techniques in genetic animal models of OCD will be crucial for rapid advances in this field, and as such we review the most recent developments and highlight the importance of searching out common circuitry defects underlying compulsive-repetitive behaviors.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Ting JT,Feng Gdoi
10.1016/j.conb.2011.04.010subject
Has Abstractpub_date
2011-12-01 00:00:00pages
842-8issue
6eissn
0959-4388issn
1873-6882pii
S0959-4388(11)00068-7journal_volume
21pub_type
杂志文章,评审abstract::Parenting is essential for survival and wellbeing in many species. Since it can be performed with little prior experience and entails considerable sacrifices without immediate benefits for the caregiver, this behavior is likely orchestrated by evolutionarily shaped, hard-wired neural circuits. At the same time, experi...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.11.011
更新日期:2020-02-01 00:00:00
abstract::Recent data show that the ventral premotor cortex in both humans and monkeys has motor and cognitive functions. The cognitive functions include space perception, action understanding and imitation. The data also show a clear functional homology between monkey area F5 and human area 44. Preliminary evidence suggests th...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(02)00308-2
更新日期:2002-04-01 00:00:00
abstract::Helping involves other-oriented actions that have the potential to benefit another. The last ten years has seen the introduction of several experimental paradigms to study helping in rats. In the best characterized of these, a free rat opens a door to release a rat trapped in an acrylic tube or pool of water. Helping ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2021.01.001
更新日期:2021-01-23 00:00:00
abstract::Here we review the mechanisms that determine projection neuron identity during cortical development. Pyramidal neurons in the mammalian cerebral cortex can be classified into two major classes: corticocortical projection neurons, which are concentrated in the upper layers of the cortex, and subcortical projection neur...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2008.05.006
更新日期:2008-02-01 00:00:00
abstract::The analysis of stimulus/response patterns using information theoretic approaches requires the full probability distribution of stimuli and response. Recent progress in using information-based tools to understand circuit function has advanced understanding of neural coding at the single cell and population level. In a...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2012.06.005
更新日期:2012-08-01 00:00:00
abstract::In recent years, interest has grown in the ability to manipulate, in a temporally precise fashion, the electrical activity of specific neurons embedded within densely wired brain circuits, in order to reveal how specific neurons subserve behaviors and neural computations, and to open up new horizons on the clinical tr...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2011.10.023
更新日期:2012-02-01 00:00:00
abstract::Extracting the structure of complex environments is at the core of our ability to interpret the present and predict the future. This skill is important for a range of behaviours from navigating a new city to learning music and language. Classical approaches that investigate our ability to extract the principles of org...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.09.014
更新日期:2019-10-01 00:00:00
abstract::Fast synaptic inhibition is largely mediated by GABA(A) receptors (GABA(A)Rs), ligand-gated chloride channels that play an essential role in the control of cell and network activity in the brain. Recent work has demonstrated that the delivery, number and stability of GABA(A)Rs at inhibitory synapses play a key role in...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2010.06.001
更新日期:2010-10-01 00:00:00
abstract::For most neurons to function properly, they need to develop synaptic specificity. This requires finding specific partner neurons, building the correct types of synapses, and fine-tuning these synapses in response to neural activity. Synaptic specificity is common at both a neuron's input and output synapses, whereby u...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2017.03.006
更新日期:2017-08-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2013.01.029
更新日期:2013-08-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(99)00059-8
更新日期:2000-02-01 00:00:00
abstract::Recent progress in our understanding of the trafficking of potassium channels can be seen in particular when considering the Kv-type channels. To date, we have discovered that folding of the Kv1.3 T1 domain begins in the ribosomal exit tunnel, and that the cell surface expression of Kv4 channels is enhanced by the pre...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.04.001
更新日期:2005-06-01 00:00:00
abstract::Sustained activity has been recorded in the prefrontal cortex during working memory tasks. First, we compare the anatomical distribution of this activity in humans and monkeys. Then, we show that it reflects many factors, maintenance of the items presented, preparation for the response, transformation of the items dur...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2004.03.003
更新日期:2004-04-01 00:00:00
abstract::It is becoming evident that neurons express an unusual number of molecules that were originally thought to be specific to immune functions. One such molecule, class I major histocompatibility complex, is required in the activity-dependent refinement and plasticity of connections in the developing and adult central ner...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00251-8
更新日期:2001-10-01 00:00:00
abstract::Associative fear learning in the basolateral amygdala (BLA) is crucial for an animal's survival upon environmental threats. BLA neurons are defined on the basis of their projection target, genetic markers, and associated function. BLA principal neuron responses to threat signaling stimuli are potentiated upon associat...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.10.005
更新日期:2015-12-01 00:00:00
abstract::Sensory perception in the real world requires proper integration of different modality inputs. Process of multisensory integration is not uniform. It varies from individual to individual and changes at different behavioral states of the animal. What factors affect multisensory integration? How does the mammalian brain...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2018.05.002
更新日期:2018-10-01 00:00:00
abstract::Many studies in the past decade have revealed the role and mechanisms of Wnt signaling in axon guidance during development and the reinduction of Wnt signaling in adult central nervous system axons upon traumatic injury, which has profound influences on axon regeneration. With 19 Wnts and 14 known receptors (10 Frizzl...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.05.005
更新日期:2014-08-01 00:00:00
abstract::The cadherin superfamily is a large (now more than 100 proteins) protein family originally identified as cell adhesion molecules. Each cadherin shows distinct expression patterns in the nervous system, and their expressions are both spatially and temporally regulated and diverse among different species. Mounting evide...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2014.06.001
更新日期:2014-10-01 00:00:00
abstract::The primary reactions of the chemo-electrical signal transduction pathway in olfactory receptor neurons are mediated by two alternative second messengers, cAMP and inositol 1,4,5-trisphosphate. The rapid and transient intracellular signalling is terminated by the action of negative-feedback loops which uncouple the re...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/0959-4388(92)90177-m
更新日期:1992-08-01 00:00:00
abstract::Stimulus-driven gene expression is a ubiquitous feature of biological systems, allowing cells and organisms to adapt their function in a stimulus-driven manner. Neurons exhibit complex and heterogeneous activity-dependent gene expression, but many of the canonical mechanisms that transduce electrical activity into gen...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2020.03.002
更新日期:2020-08-01 00:00:00
abstract::Cellular processes that mediate learning and memory show a remarkable level of conservation between vertebrates and invertebrates. Recent studies have shown that learning and memory formation in invertebrates, so-called 'simple systems', involves a highly complex arrangement of cellular pathways. Some pathways contrib...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(01)00281-1
更新日期:2001-12-01 00:00:00
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journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(96)80099-7
更新日期:1996-10-01 00:00:00
abstract::Both mammals and birds can flexibly organize their behavior over time. In mammals, the mental operations generating this ability are called executive functions and are associated with the prefrontal cortex. The corresponding structure in birds is the nidopallium caudolaterale. Anatomical, neurochemical, electrophysiol...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2005.10.003
更新日期:2005-12-01 00:00:00
abstract::In vivo tau imaging allows a deeper understanding of tau deposition in the brain, providing insights into the causes, diagnosis and treatment of primary and secondary tauopathies such as Alzheimer's disease, progressive supranuclear palsy, corticobasal syndrome, chronic traumatic encephalopathy, and some variants of f...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2015.09.002
更新日期:2016-02-01 00:00:00
abstract::The generation of a functional neuronal network requires that axons navigate precisely to their appropriate targets. Molecules that specify guidance decisions have been identified, and the signaling events that occur downstream of guidance receptors are beginning to be understood. New research shows that guidance rece...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(02)00323-9
更新日期:2002-06-01 00:00:00
abstract::Neocortex expansion in development and evolution reflects an increased and prolonged activity of neural progenitor cells. Insight into key aspects of the underlying cell biology has recently been obtained. First, the restriction of apical progenitors to undergo mitosis at the ventricular surface is overcome by generat...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2016.05.004
更新日期:2016-08-01 00:00:00
abstract::Recent work suggests that radial glial cells represent many, if not most, of the neuronal progenitors in the developing cortex. Asymmetric cell division of radial glia results in the self-renewal of the radial glial cell and the birth of a neuron. Among the proteins that direct cell fate in Drosophila melanogaster tha...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(03)00013-8
更新日期:2003-02-01 00:00:00
abstract::Emerging evidences linking pathological mechanisms of prions and tauopathies are accumulating. However, Tau assemblies do not yet fulfill all the criteria of prions. Here, we review recent data pointing similarities between prions and tauopathies and discuss the still existing uncertainties. ...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/j.conb.2019.11.022
更新日期:2020-04-01 00:00:00
abstract::Schizophrenia is often associated with cognitive deficits, particularly within the domains of memory and language. Specific cognitive deficits have recently been linked to psychotic phenomena, including verbal hallucinations and disorganized speech. Impairments of working and semantic memory are primarily due to dysfu...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00068-4
更新日期:2000-04-01 00:00:00
abstract::Comparative studies over the past year have revealed two new insights into the role of neuropeptides in the evolution of social behaviors. First, across vertebrate taxa, certain neuropeptide effects appear to be gender-specific. Second, species variations in receptor gene structure can alter neuropeptide receptor dist...
journal_title:Current opinion in neurobiology
pub_type: 杂志文章,评审
doi:10.1016/s0959-4388(00)00146-x
更新日期:2000-12-01 00:00:00