Abstract:
:Delineating the lineage of neural cells that captures the progressive steps in their specification is fundamental to understanding brain development, organization, and function. Since the earliest days of embryology, lineage questions have been addressed with methods of increasing specificity, capacity, and resolution. Yet, a full realization of individual cell lineages remains challenging for complex systems. A recent explosion of technical advances in genome-editing and single-cell sequencing has enabled lineage analysis in an unprecedented scale, speed, and depth across different species. In this review, we discuss the application of available as well as future genetic labeling techniques for tracking neural lineages in vivo in the mammalian nervous system.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Ma J,Shen Z,Yu YC,Shi SHdoi
10.1016/j.conb.2017.10.013subject
Has Abstractpub_date
2018-06-01 00:00:00pages
7-16eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30231-3journal_volume
50pub_type
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journal_title:Current opinion in neurobiology
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