Abstract:
:Glioblastoma (GBM) are aggressive and therapy-resistant brain tumours driven by glioma stem-like cells (GSCs). GSC behaviour is controlled by the microenvironment, or niche, in which the cells reside. It is well-established that the vasculature is a key component of the GSC niche, which drives maintenance in the tumour bulk and invasion at the margin. Emerging evidence now indicates that the specific properties of the vasculature within these two regions impose different functional states on resident GSCs, generating distinct subpopulations. Here, we review these recent findings, focusing on the mechanisms that underlie GSC/vascular communication. We further discuss how plasticity enables GSCs to respond to vascular changes by interconverting bidirectionally between states, and address the therapeutic implications of this dynamic response.
journal_name
Curr Opin Neurobioljournal_title
Current opinion in neurobiologyauthors
Brooks LJ,Parrinello Sdoi
10.1016/j.conb.2017.06.008subject
Has Abstractpub_date
2017-12-01 00:00:00pages
8-15eissn
0959-4388issn
1873-6882pii
S0959-4388(17)30112-5journal_volume
47pub_type
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