Schizophrenia and cognitive function.

abstract：:The crucial role of dopamine (DA) in movement control is illustrated by the spectrum of motor disorders caused by either a deficiency or a hyperactivity of dopaminergic transmission in the basal ganglia. The degeneration of nigrostriatal DA neurons in Parkinson's disease causes poverty and slowness of movement. These ...

journal_title：Current opinion in neurobiology

authors： Cenci MA,Lindgren HS

更新日期：2007-12-01 00:00:00

abstract：:Orexin deficiency results in the sleep disorder narcolepsy in many mammalian species, including mice, dogs, and humans, suggesting that the orexin system is particularly important for normal regulation of sleep/wakefulness states, and especially for maintenance of wakefulness. This review discusses animal models of na...

journal_title：Current opinion in neurobiology

authors： Sakurai T

更新日期：2013-10-01 00:00:00

abstract：:The recent invention of super-resolution fluorescence microscopy brings more than an order of magnitude gain in the spatial resolution of light microscopy. New opportunities keep emerging with the multicolor, three-dimensional, and live imaging functionalities gained in the past three years. The power of this technolo...

journal_title：Current opinion in neurobiology

authors： Dani A,Huang B

更新日期：2010-10-01 00:00:00

abstract：:This past year has seen significant advances in our understanding of the physiology of emotion. Attention continues to focus on the amygdala and its interconnections with prefrontal cortical regions. New evidence underscores the importance of lateralization for emotion. There are also new findings on the physiological...

journal_title：Current opinion in neurobiology

authors： Davidson RJ,Sutton SK

更新日期：1995-04-01 00:00:00

abstract：:In many regions of the brain, information is represented by patterns of activity occurring over populations of neurons. Understanding the encoding of information in neural population activity is important both for grasping the fundamental computations underlying brain function, and for interpreting signals that may be...

journal_title：Current opinion in neurobiology

authors： Sanger TD

更新日期：2003-04-01 00:00:00

abstract：:Classical conditioning, the simplest form of associative learning, is one of the most studied paradigms in behavioural psychology. Since the formal description of classical conditioning by Pavlov, lesion studies in animals have identified a number of anatomical structures involved in, and necessary for, classical cond...

journal_title：Current opinion in neurobiology

authors： Büchel C,Dolan RJ

更新日期：2000-04-01 00:00:00

abstract：:Pruning, a process by which neurons selectively remove exuberant or unnecessary processes without causing cell death, is crucial for the establishment of mature neural circuits during animal development. Yet relatively little is known about molecular and cellular mechanisms that govern neuronal pruning. Holometabolous...

journal_title：Current opinion in neurobiology

authors： Yu F,Schuldiner O

更新日期：2014-08-01 00:00:00

abstract：:The vestibular system provides an attractive model for understanding how changes in cellular and synaptic activity influence learning and memory in a quantifiable behavior, the vestibulo-ocular reflex. The vestibulo-ocular reflex produces eye movements that compensate for head motion; simple yet powerful forms of moto...

journal_title：Current opinion in neurobiology

authors： Gittis AH,du Lac S

更新日期：2006-08-01 00:00:00

abstract：:Fear and anxiety are debilitating conditions that affect a significant number of individuals in their lifetimes. Understanding underlying mechanisms of these disorders affords us the possibility of therapeutic intervention. Such clarity in terms of mechanism and intervention can only come from an amalgamation of resea...

journal_title：Current opinion in neurobiology

authors： Dias BG,Banerjee SB,Goodman JV,Ressler KJ

更新日期：2013-06-01 00:00:00

abstract：:Despite considerable effort over a century and the benefit of remarkable technical advances in the past few decades, we are still far from understanding mammalian cerebral neocortex. With its six layers, modular architecture, canonical circuits, innumerable cell types, and computational complexity, isocortex remains a...

journal_title：Current opinion in neurobiology

authors： Fournier J,Müller CM,Laurent G

更新日期：2015-04-01 00:00:00

abstract：:Recent work has helped reconcile puzzling results from brainstem transection studies first performed over 60 years ago, which suggested the existence of a sleep-promoting system in the medullary brainstem. It was specifically shown that GABAergic neurons located in the medullary brainstem parafacial zone (PZGABA) are ...

journal_title：Current opinion in neurobiology

authors： Anaclet C,Fuller PM

更新日期：2017-06-01 00:00:00

abstract：:The impact of microarray studies on neurobiology has been limited because, with the exception of a few outstanding papers, most reports provide little more than lists of genes, often leaving the reader at a loss to understand which and how many of the identified transcripts will be true positives with significant biol...

journal_title：Current opinion in neurobiology

authors： Henry GL,Zito K,Dubnau J

更新日期：2003-10-01 00:00:00

abstract：:The PTEN tumor suppressor gene is a lipid phosphatase that negatively regulates cell survival mediated by the phosphatidyl inositol 3' kinase-protein kinase B/Akt signaling pathway. Recent in vivo studies have revealed a novel role for PTEN in the size control of neurons. Dysregulation of cell growth control by PTEN i...

journal_title：Current opinion in neurobiology

authors： Backman S,Stambolic V,Mak T

更新日期：2002-10-01 00:00:00

abstract：:Central core (brainstem, diencephalic and basal forebrain) systems influence the functional modes of thalamic and cortical neurons during behavioral states of vigilance. Recent studies in vivo and in vitro have focused on the cellular properties of central core systems and their modulation of slow sleep oscillations, ...

journal_title：Current opinion in neurobiology

authors： Steriade M

更新日期：1993-08-01 00:00:00

abstract：:Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic st...

journal_title：Current opinion in neurobiology

authors： Blanquie O,Bradke F

更新日期：2018-08-01 00:00:00

abstract：:Cyclic nucleotide gated (CNG) cation channels are critical for signal transduction in vertebrate visual and olfactory systems. Members of the CNG channel gene family have now been cloned from a number of species, from Caenorhabditis elegans to humans. An important advance has been the discovery that CNG channels are p...

journal_title：Current opinion in neurobiology

authors： Zufall F,Shepherd GM,Barnstable CJ

更新日期：1997-06-01 00:00:00

abstract：:The issue of whether encoding of geometric information for navigational purposes crucially depends on environmental experience or whether it is innately predisposed in the brain has been recently addressed in controlled rearing studies. Non-human animals can make use of the geometric shape of an environment for spatia...

journal_title：Current opinion in neurobiology

authors： Vallortigara G,Sovrano VA,Chiandetti C

更新日期：2009-02-01 00:00:00

abstract：:Though many neuronal cell fate decisions result in reproducible outcomes, stochastic choices often lead to spatial randomization of cell subtypes. This is often the case in sensory systems where expression of a specific sensory receptor gene is selected randomly from a set of possible outcomes. Here, we describe recen...

journal_title：Current opinion in neurobiology

authors： Johnston RJ Jr,Desplan C

更新日期：2008-02-01 00:00:00

abstract：:Genetically encoded sensors of neural activity enable visualization of circuit-level function in the central nervous system. Although our understanding of the molecular events that regulate neuronal firing, synaptic function, and plasticity has expanded rapidly over the past 15 years, an appreciation for how cellular ...

journal_title：Current opinion in neurobiology

authors： Barth AL

更新日期：2007-10-01 00:00:00

abstract：:Proteoglycans are ubiquitous cell-surface and secreted glycoproteins that are involved in diverse cellular behaviors. The identities of several nervous system proteoglycans, including many of the major species in the mammalian brain, have recently come to light. In addition, recent studies have given new insights into...

journal_title：Current opinion in neurobiology

authors： Lander AD

更新日期：1993-10-01 00:00:00

abstract：:The term imprinting is used to refer to biologically relevant learning during a sensitive period defined by a particular developmental stage or physiological state. Although olfactory imprinting may occur at any age, and some of the best-studied paradigms involve adult animals, recent reports of long-term memory for o...

journal_title：Current opinion in neurobiology

authors： Hudson R

更新日期：1993-08-01 00:00:00

abstract：:The gene product responsible for autosomal recessive juvenile Parkinsonism, Parkin, has been observed to have ubiquitin ligase activity. This finding has changed the direction of studies on Parkinson's disease by suggesting that abnormal protein turnover might be involved in its pathogenesis. A number of potentially n...

journal_title：Current opinion in neurobiology

authors： Imai Y,Takahashi R

更新日期：2004-06-01 00:00:00

abstract：:A recent series of exciting observations, using novel high-resolution time-lapse imaging of living cells, has provoked a major shift in our understanding of the dendritic spine, from a stable storage site of long-term memory to a dynamic structure that undergoes rapid morphological variations. Through these recent obs...

journal_title：Current opinion in neurobiology

authors： Segal M,Andersen P

更新日期：2000-10-01 00:00:00

abstract：:Helping involves other-oriented actions that have the potential to benefit another. The last ten years has seen the introduction of several experimental paradigms to study helping in rats. In the best characterized of these, a free rat opens a door to release a rat trapped in an acrylic tube or pool of water. Helping ...

journal_title：Current opinion in neurobiology

authors： Mason P

更新日期：2021-01-23 00:00:00

abstract：:Parenting is essential for survival and wellbeing in many species. Since it can be performed with little prior experience and entails considerable sacrifices without immediate benefits for the caregiver, this behavior is likely orchestrated by evolutionarily shaped, hard-wired neural circuits. At the same time, experi...

journal_title：Current opinion in neurobiology

authors： Kohl J

更新日期：2020-02-01 00:00:00

abstract：:General anesthesia is a man-made neurophysiological state comprised of unconsciousness, amnesia, analgesia, and immobility along with maintenance of physiological stability. Growing evidence suggests that anesthetic-induced neural oscillations are a primary mechanism of anesthetic action. Each anesthetic drug class pr...

journal_title：Current opinion in neurobiology

authors： Akeju O,Brown EN

更新日期：2017-06-01 00:00:00

abstract：:Opiate drugs such as morphine and heroin are among the most effective analgesics known. Prolonged or repeated administration of opiates produces adaptive changes in the nervous system that lead to reduced drug potency or efficacy (tolerance), as well as physiological withdrawal symptoms and behavioral manifestations s...

journal_title：Current opinion in neurobiology

authors： von Zastrow M,Svingos A,Haberstock-Debic H,Evans C

更新日期：2003-06-01 00:00:00

abstract：:Adult somatic stem cells are generally defined as cells with the ability to differentiate into multiple different lineages and to self-renew during long periods of time. These features were long presumed to be represented in one single tissue-specific stem cell. Recent development of single-cell technologies reveals t...

journal_title：Current opinion in neurobiology

authors： Llorens-Bobadilla E,Martin-Villalba A

更新日期：2017-02-01 00:00:00

abstract：:The importance of the medial temporal lobe to episodic memory has been recognized for decades. Recent human fMRI findings have begun to delineate the functional roles of different MTL regions, most notably the hippocampus, for the retrieval of episodic memories. Importantly, these studies have also identified a networ...

journal_title：Current opinion in neurobiology

authors： Rugg MD,Vilberg KL

更新日期：2013-04-01 00:00:00

abstract：:A recent approach in social neuroscience has been the application of formal computational models for a particular social-cognitive process to neuroimaging data. Here we review preliminary findings from this nascent subfield, focusing on observational learning and strategic interactions. We present evidence consistent ...

journal_title：Current opinion in neurobiology

authors： Dunne S,O'Doherty JP

更新日期：2013-06-01 00:00:00