Abstract：
:Medical sheets are useful in surgically repair vascular disease. To avoid long-term side effects, they are to be replaced with regenerated tissue after implantation. Silk fibroin is a fibrous protein secreted by silkworm. The advantage of silk fibroin is its biocompatibility and has been used as regenerative artificial materials. The problem of its biodegradability is that the effect is time consuming. In this study, SVVYGLR peptide was used to expect promoting cell migration and accelerating the biodegradation of silk fibroin. Silk fibroin and polyurethane-based medical sheets with or without SVVYGLR peptide were implanted in rat abdominal aorta (silk fibroin/polyurethane/SVVYGLR peptide versus silk fibroin/polyurethane). The result of histological evaluation indicated that the new cell layer created under both sheets was composed of endothelial cells, smooth muscle, and fibroin in both sheets and similar to a native vessel. Both sheets did not show any excessive inflammation or calcification, and moderate biodegradability was observed. The decrease of silk fibroin indicated the biodegradability of all sheets. Silk fibroin/polyurethane/SVVYGLR peptide had many small vessels in the regenerated tissue than silk fibroin/polyurethane. This appearance indicated that SVVYGLR peptide promoted the angiogenesis in the regenerative tissue. This study suggested that SVVYGLR peptide could give the angiogenic-promoting activity to silk fibroin-based vascular repairing sheet.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Shimada K,Honda T,Kato K,Hori R,Ujike N,Uemura A,Murakami T,Kitpipatkun P,Nakazawa Y,Tanaka Rdoi
10.1177/0885328220928660subject
Has Abstractpub_date
2020-06-02 00:00:00pages
885328220928660eissn
0885-3282issn
1530-8022pub_type
杂志文章abstract：:At present all the commercially available "medical grade" urethane elastomers exhibit a phenomenon known as environmental stress cracking (ESC). This phenomenon is characterized by surface microcracking when the elastomer is elongated while in vivo. The degree of strain that is required to initiate microcracking varie...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829100600202
更新日期：1991-10-01 00:00:00
abstract：:The different barriers that slow the penetration of active ingredients administered by the ocular route are described, and some novel dosage forms designed for this route are discussed. Both precorneal and corneal factors considerably restrict ocular penetration. The low bioavailability of classical ophthalmic dosage ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829701100305
更新日期：1997-01-01 00:00:00
abstract：:Calcium phosphate fillers have been shown to increase cement osteoconductivity, but have caused drawbacks in cement properties. Hydroxyapatite and Brushite were introduced in an acrylic two-solution cement at varying concentrations. Novel composite bone cements were developed and characterized using rheology, injectab...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214544770
更新日期：2014-11-01 00:00:00
abstract：:The setup of colloidal hybrid nanosystems based on biomimetic calcium phosphate apatites doped with europium ions has recently raised great interest in the pharmacological community, especially due to their bio-inspired character. This is especially relevant in relation with medical imaging for cancer diagnosis. Quest...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212473510
更新日期：2014-01-01 00:00:00
abstract：:Phenylalanine ethyl ester (PAE)-alginate (Alg) conjugate (PAE-Alg, PEA) was synthesized and formation of an amide bond between PAE and Alg was confirmed by Fourier transformed-infrared and (1)H nuclear magnetic resonance spectroscopy. The degree of PAE substitution was 3.5-4.7 (PAE group per hundred sugar residues of ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328216630497
更新日期：2016-07-01 00:00:00
abstract：:Glass Polyalkenoate Cements (GPCs) based on strontium calcium zinc silicate (Sr-Ca-Zn-SiO2) glasses and high molecular weight poly(acrylic acid) (PAA) have been shown to exhibit suitable mechanical properties for orthopaedic arthroplasty applications, however for vertebroplasty and other medical luting applications th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328208099085
更新日期：2010-02-01 00:00:00
abstract：:Poly(ethylene glycol)-poly(lactic acid) (PEG-PLA) copolymers have been widely used for various biomedical applications. However, their hemocompatibility has not been clarified, which would lag their developments and clinical applications. In this work, we studied the effect of PEG-PLA copolymers on key human blood com...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215627404
更新日期：2016-05-01 00:00:00
abstract：:Polysulfone (PSU) composite films filled with Beta-dicalcium silicate (Beta-Ca(2)SiO(4)) particles are prepared by the solvent casting-evaporation method. The surface morphologies and mechanical properties of the films are determined. The bioactivity of the composite films is evaluated by soaking them in simulated bod...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328206054712
更新日期：2006-04-01 00:00:00
abstract：:An experimental and computational investigation of the self-tapping ability of carbon fibre reinforced polyetheretherketone (CFR-PEEK) has been conducted. Six CFR-PEEK suture anchor designs were investigated using PEEK-OPTIMA® Reinforced, a medical grade of CFR-PEEK. Experimental tests were conducted to investigate th...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214535274
更新日期：2014-10-01 00:00:00
abstract：:Type 1 diabetes mellitus is a serious disease comprising approximately 10% of all diabetes cases, and the global incidence of type 1 diabetes mellitus is steadily rising without any promise of a cure in the near future. Although islet transplantation has proven to be an effective means of treating type 1 diabetes mell...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章,评审
doi：10.1177/0885328219831391
更新日期：2019-04-01 00:00:00
abstract：:Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer res...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211427774
更新日期：2013-03-01 00:00:00
abstract：:Bioimaging at a subcellular resolution to label cytoplasm and nucleus in living cell by just one photoluminescent nanoparticle has great application potential in bioresearch, preclinical diagnosis, screening, and image-guided therapy of life-threatening diseases. Herein, we report a novel arginine (Arg) functionalized...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217725203
更新日期：2017-10-01 00:00:00
abstract：:The purpose of this study was to develop a specific targeting magnetic nanoparticle probe for magnetic resonance imaging and therapy in the form of local hyperthermia. Carboxymethyl dextran-coated ultrasmall superparamagnetic iron oxide nanoparticles with carboxyl groups were coupled to cyclic arginine-glycine-asparti...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328213493486
更新日期：2014-03-01 00:00:00
abstract：:The objective of this study is to evaluate the osteoconductivity and bioactivity of the Bonelike graft in repairing surgical cystic bone defects. Bonelike is implanted in 11 patients, aged between 24 and 53 years with a mean age of 36 years, consisting of 5 men and 6 women. According to the standard follow up protocol...
journal_title：Journal of biomaterials applications
pub_type： 临床试验,杂志文章
doi：10.1177/0885328207078260
更新日期：2008-01-01 00:00:00
abstract：:The process of molecular self-assembly plays a crucial role in formulation of polymeric nanoparticulated drug delivery carriers as it creates the possibility for enhanced drug encapsulation and carrier surface engineering. This study aimed to develop a novel self-assembled polymeric micelles for targeted delivery in t...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214549612
更新日期：2015-01-01 00:00:00
abstract：:The layer-by-layer technique, which allows simple preparation of polyelectrolyte multilayers, came into the focus of research for development of functionalized medical devices. Numerous literature exist that concentrate on the film build-up and the behaviour of cells on polyelectrolyte multilayers. However, in case of...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212437610
更新日期：2013-07-01 00:00:00
abstract：:Engineered anisotropic tissue constructs containing aligned cell and extracellular matrix structures are useful as in vitro models and for regenerative medicine. They are of particular interest for nervous system modelling and regeneration, where tracts of aligned neurons and glia are required. The self-alignment of c...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215597818
更新日期：2015-11-01 00:00:00
abstract：:Bone tissue is dependent on an efficient blood supply to ensure delivery of nutrients and oxygen. One method to acquire a vascular-engineered bone tissue could be the use of an angiogenic gene-activated scaffold. In the current study, porous chitosan/hydroxyapatite (C/HA) scaffolds were fabricated via freeze-drying wi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328214544769
更新日期：2014-11-01 00:00:00
abstract：:A biodegradable polylactic acid composite containing tricalcium phosphate microsphere was fabricated. The composite exhibited enhanced biocompatibility and a well-interconnected porous structure that enabled tissue ingrowth after degradation. The tricalcium phosphate microspheres had an average size of 106 ± 43 μm and...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328218763660
更新日期：2018-05-01 00:00:00
abstract：:Phase-sensitive in situ gel-forming controlled release formulations of insulin were prepared using poly(lactide-co-glycolide) and a solvent system consisting of various proportions of benzyl benzoate and benzyl alcohol. The in vitro release samples of formulations were assayed for insulin content by enzyme linked immu...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328209359959
更新日期：2011-03-01 00:00:00
abstract：:In this work, gold embedded chitosan nanoparticles (Au@CS NPs) were fabricated by a one-pot method. The benzaldehyde-terminated poly[(2-methacryloyloxy) ethyl phosphorylcholine] (PMPC) was applied to modification of the gold doped chitosan nanoparticles. The obtained Au@CS-PMPC NPs had the diameter of 135 nm with a na...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220952594
更新日期：2020-08-27 00:00:00
abstract：:Fracture resistance of provisional restorations is an important clinical concern. This property is directly related to transverse strength. Strengthening of provisional fixed partial dentures may result from reinforcement with various fiber types. This study evaluated the effect of fiber type and water storage on the ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328203017004003
更新日期：2003-04-01 00:00:00
abstract：:Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in wor...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328215568985
更新日期：2015-07-01 00:00:00
abstract：:Nanodrug delivery systems have been widely researched to achieve efficient antitumor drug delivery. However, the controlled drug delivery at tumor cells remains the main challenge for antitumor therapy. Herein, a pH and reduction-responsive nanocarrier based on green tea polyphenols was employed as a smart excipient f...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328220924539
更新日期：2020-08-01 00:00:00
abstract：:Nonviral gene delivery systems are finding widespread use due to their safety, rapid and economical production, and ease of modification. In this work, series of N-alkyl-substituted linear polyethylenimine (CP) polymers have been synthesized, characterized, and investigated about how degree of substitution (hydrophobi...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328217710125
更新日期：2017-07-01 00:00:00
abstract：:The in vitro effect of platelet-rich plasma (PRP) on cell loading, proliferation, and osteogenic differentiation of human mesenchymal stem cells (MSC) is assessed on distinct resorbable and synthetic calcium phosphate scaffolds. A high specific surface area scaffold composed of calcium-deficient hydroxyapatite (CDHA; ...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328207088269
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:To produce biodurable small diameter microporous vascular grafts with self-sealing properties for vascular access, for peripheral vascular and potentially for coronary artery bypass. The prosthesis should retain compliance and pulsatile flow in situ using a unique modus operandi permitting wall compression whic...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/088532829501000207
更新日期：1995-10-01 00:00:00
abstract：:The aim of this pilot study was to evaluate the bioactive, surface-coated polycaprolactone-co-lactide scaffolds as bone implants in a tibia critical size defect model. Polycaprolactone-co-lactide scaffolds were coated with collagen type I and chondroitin sulfate and 30 piled up polycaprolactone-co-lactide scaffolds we...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212471409
更新日期：2014-01-01 00:00:00
abstract：:Reconstruction of critical sized bone injuries is a major problem that continues to inspire the design of new materials and grafts. Natural ceramics (hydroxyapatite (HA) coralline HA, or synthetic HA) and β-tricalcium phosphate (β-TCP) are being explored for use as scaffolds in bone tissue engineering, among several o...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328211415132
更新日期：2013-01-01 00:00:00
abstract：:This investigation describes the synthesis and in vitro evaluation of cationic hydrogel sub-microparticles based on polydimethylaminoethylmethacrylate for oral insulin delivery. Polymerization of dimethylaminoethylmethacrylate was carried out in aqueous medium with potassium persulfate as the initiator. Quaternization...
journal_title：Journal of biomaterials applications
pub_type： 杂志文章
doi：10.1177/0885328212437392
更新日期：2013-07-01 00:00:00
