Abstract:
:Pluronic® F127 is a biocompatible, injectable, and thermoresponsive polymer with promising biomedical applications. In this study, a chemically modified form, i.e., Pluronic ALA-L with tailored degradation rate, was tested as an encapsulation vehicle for osteoblastic cells. UV cross-linking of the modified polymer results in a stable hydrogel with a slower degradation rate. Toxicological screening showed no adverse effects of the modified Pluronic ALA-L on the cell viability. Moreover, high viability of embedded cells in the cross-linked Pluronic ALA-L was observed with life/death fluorescent staining during a 7-day-culture period. Cells were also cultured on macroporous, cross-linked gelatin microbeads, called CultiSpher-S® carriers, and encapsulated into the modified cross-linked hydrogel. Also, in this situation, good cell proliferation and migration could be observed in vitro. Preliminary in vivo tests have shown the formation of new bone starting from the injected pre-loaded CultiSpher-S® carriers.
journal_name
J Biomater Appljournal_title
Journal of biomaterials applicationsauthors
Lippens E,Swennen I,Gironès J,Declercq H,Vertenten G,Vlaminck L,Gasthuys F,Schacht E,Cornelissen Rdoi
10.1177/0885328211427774subject
Has Abstractpub_date
2013-03-01 00:00:00pages
828-39issue
7eissn
0885-3282issn
1530-8022pii
0885328211427774journal_volume
27pub_type
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